INT102896

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.55
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
neural crest 1
neurons 1
IB4 1
nociceptors 1
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 82 99.22 Very High Very High Very High
unmyelinated 9 98.82 Very High Very High Very High
Neuropeptide 33 94.80 High High
trigeminal ganglion 62 89.52 High High
Spinal cord 27 88.52 High High
dorsal root ganglion 71 87.88 High High
Peripheral nervous system 4 87.24 High High
Nerve growth factor 163 81.24 Quite High
tetrodotoxin 7 73.76 Quite High
neurotrophin 3 6 73.52 Quite High
Disease Link Frequency Relevance Heat
Repression 3 99.10 Very High Very High Very High
Neuroblastoma 2 96.04 Very High Very High Very High
Targeted Disruption 49 95.04 Very High Very High Very High
Ganglion Cysts 267 89.52 High High
Apoptosis 20 87.00 High High
Nociception 38 84.16 Quite High
Pain 15 46.00 Quite Low
INFLAMMATION 11 42.32 Quite Low
Hematological Disease 2 37.72 Quite Low
Embryonic Lethality 1 33.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GDNF-overexpresser mice had increased numbers of small unmyelinated sensory neurons that express the tyrosine kinase receptor Ret and bind the plant isolectin B4 (IB4).
Ret Binding (bind) of in IB4 associated with unmyelinated
1) Confidence 0.35 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019325 Disease Relevance 0.19 Pain Relevance 0.24
Signal transduction occurs by interaction with the transmembrane receptor ret (c-ret).
ret Binding (interaction) of
2) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.23
ret appears not to be required for cell viability but for TRPA1 expression
ret Binding (appears) of
3) Confidence 0.26 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.09 Pain Relevance 0.18
On the other hand, Runx1 is essential for the late repression of trkA and induction of Ret when TrkA+ and Ret+ neurons segregate (Figure 1b) [34].
Ret Binding (segregate) of in neurons associated with repression
4) Confidence 0.26 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.60 Pain Relevance 0.28
Thus Grik1/GluR5 expression seems to coincide with the appearance of the population of nociceptors that down-regulate TrkA and express c-Ret and bind isolectin B4 [8].
Ret Binding (bind) of in nociceptors associated with nociceptor
5) Confidence 0.26 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.36
Expression of Dok4 has been described in the DRG during embryonic development, and an interaction with c-Ret was demonstrated in a heterologous cell expression system [14].
Ret Binding (interaction) of
6) Confidence 0.25 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.16 Pain Relevance 0
During EB culture in BDNF(+) medium, we detected each immunoreactivity associated with the trk proto-oncogenes (trkB; BDNF receptors) and neural crest marker, proto-oncogene tyrosine-protein kinase receptor ret precursor (c-ret), p75, or sox9.
c-ret Binding (associated) of in neural crest
7) Confidence 0.14 Published 2006 Journal Stem Cells Section Abstract Doc Link 16527901 Disease Relevance 0 Pain Relevance 0.07
GDNF binds most readily to GFR alpha-1, but also binds to GFR alpha-2 / c-ret heterodimers [50].
c-ret Binding (binds) of
8) Confidence 0.02 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.51 Pain Relevance 0.67

General Comments

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