INT102897

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 11.13
Pain Relevance 13.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
skin 14
neurons 10
brain 6
sensory neuron 4
IB4 4
Gdnf (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 466 100.00 Very High Very High Very High
Inflammation 69 100.00 Very High Very High Very High
antidepressant 8 100.00 Very High Very High Very High
c fibre 209 99.96 Very High Very High Very High
Morphine 17 99.96 Very High Very High Very High
Nucleus accumbens 2 99.68 Very High Very High Very High
intrathecal 16 99.44 Very High Very High Very High
nMDA receptor 2 99.44 Very High Very High Very High
Spinal cord 87 99.32 Very High Very High Very High
allodynia 46 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 234 99.88 Very High Very High Very High
Hypersensitivity 51 99.28 Very High Very High Very High
Neuropathic Pain 58 98.92 Very High Very High Very High
INFLAMMATION 68 98.20 Very High Very High Very High
Ganglion Cysts 794 98.04 Very High Very High Very High
Drug Dependence 7 98.04 Very High Very High Very High
Pain 40 97.80 Very High Very High Very High
Nociception 51 97.48 Very High Very High Very High
Injury 10 96.48 Very High Very High Very High
Parkinsonian Disorders 63 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that enhanced expression of GDNF in the skin can change mechanical sensitivity of IB4-positive nociceptive afferents and that this may occur through enhanced expression of specific types of channel proteins.
Positive_regulation (enhanced) of Gene_expression (expression) of GDNF in IB4 associated with nociception
1) Confidence 0.69 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.23 Pain Relevance 0.47
Repeated treatment with MOR for 9 days, which results in an enhancement of the locomotor-stimulating effects (sensitization) of MOR, increased GDNF levels in the nucleus accumbens compared with those in saline-treated mice.
Positive_regulation (increased) of Gene_expression (levels) of GDNF in nucleus accumbens associated with nucleus accumbens and morphine
2) Confidence 0.50 Published 2007 Journal Behav. Brain Res. Section Abstract Doc Link 17331595 Disease Relevance 0.30 Pain Relevance 1.09
In the case of GDNF overexpression in skin, the mechanical thresholds of C fibre afferents decrease, with LTMR showing a heat responsiveness not observed in wildtype animals.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GDNF in skin associated with c fibre
3) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.06 Pain Relevance 0.27
Overexpression of GDNF in transgenic mice under control of the K14 keratin gene promoter results in a six-fold increase of GDNF protein in skin (Zwick et al. 2002).
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GDNF in skin associated with targeted disruption
4) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.23 Pain Relevance 0.29
The downregulation of TRPV1 by overexpression of GDNF in vivo demonstrates, however, that regulatory processes in culture cannot be easily extrapolated to the situation in situ.


Positive_regulation (overexpression) of Gene_expression (overexpression) of GDNF
5) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0.49
Overexpression of GDNF in mouse skin increases mechanical sensitivity of C fibres
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GDNF in skin associated with c fibre
6) Confidence 0.49 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.22 Pain Relevance 0.26
Moreover, we mentioned the potential of Leu-Ile, which induces the expression of GDNF and TNF-alpha, as a novel therapeutic agent for drug dependence.
Positive_regulation (induces) of Gene_expression (expression) of GDNF associated with drug dependence and addiction
7) Confidence 0.48 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17538232 Disease Relevance 0.80 Pain Relevance 0.94
Activation of mGlu3 receptors enhances GDNF levels in cultured striatal
                   neurons (but not in astrocytes) via the activation of the MAP kinase and the
                   phosphatidylinositol-3-kinase pathways
Positive_regulation (activation) of Gene_expression (levels) of GDNF in neurons
8) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.29 Pain Relevance 0
Activation of mGlu3 receptors enhances GDNF levels in cultured striatal
                   neurons (but not in astrocytes) via the activation of the MAP kinase and the
                   phosphatidylinositol-3-kinase pathways
Positive_regulation (enhances) of Gene_expression (levels) of GDNF in neurons
9) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.29 Pain Relevance 0
Using pure cultures of striatal neurons we could
               establish that activation of mGlu3 receptors enhanced GDNF production by stimulating
               the MAPK and the PI-3-K pathways. 
Positive_regulation (enhanced) of Gene_expression (production) of GDNF in neurons
10) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0 Pain Relevance 0.07
To elucidate the functional properties of GDNF-dependent nociceptors and distinguish them from nociceptors that retain NGF dependence, the cellular and physiologic properties of sensory neurons of wild-type and transgenic mice that overexpress GDNF in the skin (GDNF-OE) were analyzed using a skin, nerve, dorsal root ganglion, and spinal cord preparation, immunolabeling, and reverse transcriptase-PCR assays.
Positive_regulation (overexpress) of Gene_expression (overexpress) of GDNF-OE in skin associated with ganglion cysts, targeted disruption, dorsal root ganglion, addiction, nerve growth factor, nociceptor and spinal cord
11) Confidence 0.47 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16540576 Disease Relevance 0.20 Pain Relevance 0.79
To examine the survival and phenotypic effects of GDNF on sensory neurons in vivo, we generated transgenic mice that overexpress GDNF in the skin.
Positive_regulation (overexpress) of Gene_expression (overexpress) of GDNF in sensory neurons associated with targeted disruption
12) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019325 Disease Relevance 0.18 Pain Relevance 0.26
[27], suggesting that
               strategies aimed at enhancing the endogenous production of both GDNF and
               TGF-? 
Positive_regulation (enhancing) of Gene_expression (production) of GDNF
13) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.65 Pain Relevance 0.06
We decided to examine whether doses of 0.25 or 3 mg/kg of LY379268, which
                   enhanced GDNF levels in the striatum, were protective against nigro-striatal
                   damage in mice treated with MPTP. 
Positive_regulation (enhanced) of Gene_expression (levels) of GDNF in striatum associated with parkinson's disease
14) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.49 Pain Relevance 0.04
increased glial cell line-derived neurotrophic factor (GDNF) mRNA and protein
                   levels in the mouse brain, as assessed by in situ
                   hybridization, real-time PCR, immunoblotting, and immunohistochemistry. 
Positive_regulation (increased) of Gene_expression (levels) of GDNF in brain
15) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2719807 Disease Relevance 0.32 Pain Relevance 0.26
A single injection of
                   LY379268 alone enhanced GDNF levels by more than 2 fold after 1 day. 
Positive_regulation (enhanced) of Gene_expression (levels) of GDNF
16) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.49 Pain Relevance 0.03
We have now extended this function to neurons, where
               activation of mGlu3 receptors stimulated GDNF production. 
Positive_regulation (stimulated) of Gene_expression (production) of GDNF in neurons
17) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.07 Pain Relevance 0.23
Alterations in the response to mechanical and thermal stimuli in mice overexpressing GDNF and artemin demonstrate the potential of these growth factors to tune sensory neuron properties.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GDNF in sensory neuron
18) Confidence 0.43 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.23
In mice overexpressing NGF or GDNF the expression patterns for several genes were substantially altered; these changes in injury-evoked patterns of gene expression suggest the existence of endogenous regulatory mechanisms that can compensate for increased nociceptive input by modulating the expression of a limited subset of genes.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GDNF associated with nociception, nerve growth factor and injury
19) Confidence 0.42 Published 2005 Journal Pain Section Abstract Doc Link 15661434 Disease Relevance 1.06 Pain Relevance 0.44
The use
               of brain-permeant drugs that mimic the action of GDNF or enhance the production of
               endogenous GDNF is an attractive strategy that may overcome the limitations
               associated with an invasive delivery of GDNF into the brain. 
Positive_regulation (enhance) of Gene_expression (production) of GDNF in brain
20) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719807 Disease Relevance 0.38 Pain Relevance 0.14

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