INT1029

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Context Info
Confidence 0.50
First Reported 1975
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 11.03
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Lbp) transport (Lbp) extracellular space (Lbp)
extracellular region (Lbp)
Anatomy Link Frequency
mere 10
erector spinae 2
liver 2
general development 2
leg 2
Lbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
backache 311 100.00 Very High Very High Very High
Pain 251 99.48 Very High Very High Very High
Sciatica 5 81.80 Quite High
Inflammation 32 80.92 Quite High
Inflammatory response 18 78.08 Quite High
Chronic low back pain 1 75.00 Quite High
methotrexate 1 68.64 Quite High
cytokine 11 66.92 Quite High
Inflammatory mediators 4 60.52 Quite High
spinal stenosis 2 31.64 Quite Low
Disease Link Frequency Relevance Heat
Low Back Pain 314 100.00 Very High Very High Very High
Sepsis 237 99.92 Very High Very High Very High
Insulin Resistance 16 98.36 Very High Very High Very High
Infection 123 98.28 Very High Very High Very High
Pressure And Volume Under Development 52 97.68 Very High Very High Very High
Critical Illness 7 96.48 Very High Very High Very High
Hyperlipidemia 2 95.52 Very High Very High Very High
Systemic Inflammatory Response Syndrome 81 94.32 High High
Pain 257 93.72 High High
Stress 4 93.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no over-representation of LBP in the groups with residual deformity, with limping or with leg length discrepancy.
Positive_regulation (over-representation) of Neg (no) Gene_expression (over-representation) of LBP in leg
1) Confidence 0.50 Published 1975 Journal Scand J Rehabil Med Section Abstract Doc Link 130675 Disease Relevance 0.16 Pain Relevance 0.07
The current episode was the first ever experience of LBP in 24% of subjects, while over half (55%) had been troubled by episode(s) of LBP for ?
Positive_regulation (experience) of Gene_expression (experience) of LBP associated with backache
2) Confidence 0.49 Published 2007 Journal Chiropr Osteopat Section Body Doc Link PMC1852566 Disease Relevance 0.48 Pain Relevance 0.48
Of these 969 individuals, 524 (54%) experienced LBP in the previous 12 months, with a modal frequency of three or more times a year.
Positive_regulation (experienced) of Gene_expression (experienced) of LBP
3) Confidence 0.49 Published 2004 Journal N. Z. Med. J. Section Body Doc Link 15477923 Disease Relevance 0.08 Pain Relevance 0
In addition, the liver increases the synthesis of Acute Phase Proteins (APP), including LPS binding protein (LBP), whose serum levels are markedly increased in rats with PH.
Positive_regulation (increases) of Gene_expression (synthesis) of LBP in liver associated with pressure and volume under development
4) Confidence 0.48 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2262079 Disease Relevance 1.76 Pain Relevance 0.24
This increase persisted even after the following conservative adjustments: (a) excluding all radiology expenses that occurred coincident with LBP; (b) excluding billings for non-LBP conditions that occurred on days of any LBP visit because these charges may have reflected mere convenience "shopping or servicing" behavior; (c) excluding patients with a baseline of low healthcare utilization before LBP initiation because convenience may have been especially important for this cohort.
Positive_regulation (-) of Gene_expression (conditions) of LBP in mere
5) Confidence 0.48 Published 2010 Journal Spine Section Body Doc Link 20228698 Disease Relevance 0.05 Pain Relevance 0
This increase persisted even after the following conservative adjustments: (a) excluding all radiology expenses that occurred coincident with LBP; (b) excluding billings for non-LBP conditions that occurred on days of any LBP visit because these charges may have reflected mere convenience "shopping or servicing" behavior; (c) excluding patients with a baseline of low healthcare utilization before LBP initiation because convenience may have been especially important for this cohort.
Positive_regulation (occurred) of Gene_expression (conditions) of LBP in mere
6) Confidence 0.48 Published 2010 Journal Spine Section Body Doc Link 20228698 Disease Relevance 0.05 Pain Relevance 0
This increase persisted even after the following conservative adjustments: (a) excluding all radiology expenses that occurred coincident with LBP; (b) excluding billings for non-LBP conditions that occurred on days of any LBP visit because these charges may have reflected mere convenience "shopping or servicing" behavior; (c) excluding patients with a baseline of low healthcare utilization before LBP initiation because convenience may have been especially important for this cohort.
Positive_regulation (days) of Gene_expression (visit) of LBP in mere
7) Confidence 0.42 Published 2010 Journal Spine Section Body Doc Link 20228698 Disease Relevance 0.05 Pain Relevance 0
This increase persisted even after the following conservative adjustments: (a) excluding all radiology expenses that occurred coincident with LBP; (b) excluding billings for non-LBP conditions that occurred on days of any LBP visit because these charges may have reflected mere convenience "shopping or servicing" behavior; (c) excluding patients with a baseline of low healthcare utilization before LBP initiation because convenience may have been especially important for this cohort.
Positive_regulation (-) of Gene_expression (visit) of LBP in mere
8) Confidence 0.42 Published 2010 Journal Spine Section Body Doc Link 20228698 Disease Relevance 0.05 Pain Relevance 0
This increase persisted even after the following conservative adjustments: (a) excluding all radiology expenses that occurred coincident with LBP; (b) excluding billings for non-LBP conditions that occurred on days of any LBP visit because these charges may have reflected mere convenience "shopping or servicing" behavior; (c) excluding patients with a baseline of low healthcare utilization before LBP initiation because convenience may have been especially important for this cohort.
Positive_regulation (-) of Gene_expression (coincident) of LBP in mere
9) Confidence 0.42 Published 2010 Journal Spine Section Body Doc Link 20228698 Disease Relevance 0.06 Pain Relevance 0
To confirm that this reduced variability in the timing of APAs is also evident in people with chronic LBP, the authors examined the standard deviations of electromyographic onset latencies from the bilateral internal oblique (IO) and erector spinae muscles (in relation to deltoid muscle onset) when 10 people with chronic LBP and 10 people without LBP performed 75 trials of rapid arm raises.
Positive_regulation (variability) of Spec (evident) Gene_expression (evident) of LBP in erector spinae
10) Confidence 0.41 Published 2009 Journal Behav. Neurosci. Section Abstract Doc Link 19331469 Disease Relevance 0.17 Pain Relevance 0.17
What is the general development of LBP?
Positive_regulation (general development) of Gene_expression (general development) of LBP in general development associated with backache
11) Confidence 0.40 Published 2010 Journal Chiropr Osteopat Section Body Doc Link PMC2820484 Disease Relevance 0.92 Pain Relevance 0.92
Pre-pregnancy history of LBP was identified from the question: "Have you suffered from LBP before you were pregnant (yes, no)?"


Positive_regulation (suffered) of Gene_expression (suffered) of LBP associated with backache
12) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2890600 Disease Relevance 1.54 Pain Relevance 1.45
As several of the items in WHODAS II were linked to more than one ICF category, this resulted in additionally 11 items in WHODAS II not being covered by the Comprehensive ICF Core Set for LBP (Tables 2, 3 and 4).
Neg (not) Positive_regulation (covered) of Neg (not) Gene_expression (covered) of LBP associated with backache
13) Confidence 0.27 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770393 Disease Relevance 0.51 Pain Relevance 0.44
The severity of LBP has rarely been taken into consideration in these studies.
Positive_regulation (severity) of Gene_expression (severity) of LBP associated with backache
14) Confidence 0.26 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1920507 Disease Relevance 1.32 Pain Relevance 1.32
METHODS: A total of 102 occupational male, 20-40 yrs of age, with sub-acute or chronic nonspecific LBP were randomized and treated either with conventional treatment a combination of two electrotherapy (ultrasound and short wave diathermy) and one exercise therapy (lumbar strengthening exercises) or dynamic muscular stabilization techniques (DMST) an active approach of stabilizing training.
Positive_regulation (treated) of Gene_expression (randomized) of LBP
15) Confidence 0.24 Published 2009 Journal J Back Musculoskelet Rehabil Section Body Doc Link 20023348 Disease Relevance 0.10 Pain Relevance 0
Levels of LBP, IL-6 and CRP increased progressively with increasing severity of infection/sepsis.
Positive_regulation (increased) of Gene_expression (Levels) of LBP associated with sepsis and infection
16) Confidence 0.15 Published 2006 Journal Crit Care Section Body Doc Link PMC1550885 Disease Relevance 1.42 Pain Relevance 0.03
Gaini et al. in their studies in sepsis patients accordingly observed LBP levels of 33.5 ?
Positive_regulation (observed) of Gene_expression (levels) of LBP associated with sepsis
17) Confidence 0.11 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 1.15 Pain Relevance 0.03
In our study patients with severe sepsis median LBP level was 79.7 ?
Positive_regulation (79.7) of Gene_expression (level) of LBP associated with sepsis
18) Confidence 0.09 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2831899 Disease Relevance 1.16 Pain Relevance 0.03

General Comments

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