INT102901

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 2.42
Pain Relevance 3.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
neurons 4
neuronal 2
substantia nigra 2
striatum 2
dopaminergic neurons 2
Th (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
midbrain 22 99.84 Very High Very High Very High
Substantia nigra 20 99.52 Very High Very High Very High
Dopamine 381 99.20 Very High Very High Very High
Morphine 1 98.14 Very High Very High Very High
Ventral tegmentum 37 96.96 Very High Very High Very High
Locus ceruleus 17 96.14 Very High Very High Very High
monoamine 45 96.04 Very High Very High Very High
opiate 6 95.92 Very High Very High Very High
withdrawal 2 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ocular Toxicity (including Many Sub-types) 11 99.44 Very High Very High Very High
Sprains And Strains 19 98.72 Very High Very High Very High
Substance Withdrawal Syndrome 1 95.36 Very High Very High Very High
Lordosis 26 94.92 High High
Parkinson's Disease 11 93.00 High High
Neurodegenerative Disease 11 92.76 High High
INFLAMMATION 34 92.40 High High
Death 21 91.76 High High
Creutzfeldt Jakob Disease 1 91.48 High High
Urological Neuroanatomy 29 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that noradrenergic locus ceruleus (LC) neurons of mice with a conditional deletion of BDNF in postnatal brain respond to chronic morphine treatment with a paradoxical downregulation of cAMP-mediated excitation and lack of dynamic regulation of TH expression.
Regulation (regulation) of Gene_expression (expression) of TH in neurons associated with locus ceruleus and morphine
1) Confidence 0.60 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019333 Disease Relevance 0.18 Pain Relevance 0.98
Ovariectomy of the female does not affect TH expression, while chronic treatment with high levels of estradiol reduces its expression [7,20].
Neg (not) Regulation (affect) of Gene_expression (expression) of TH
2) Confidence 0.46 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.13 Pain Relevance 0
In addition neuronal cell counts were performed in the SNc to control for changes in TH expression in atrophic neurons.
Regulation (changes) of Gene_expression (expression) of TH in neuronal
3) Confidence 0.36 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0.09 Pain Relevance 0.14
Although there is extensive evidence for TH-ir neurones in the lesioned rodent striatum, there are few details regarding the molecular phenotype of these neurones, regulation of their TH expression after l-3,4-dihydroxyphenylalanine (L-DOPA) treatment and their function.
Regulation (regulation) of Gene_expression (expression) of TH in striatum
4) Confidence 0.35 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279311 Disease Relevance 0.09 Pain Relevance 0.08
Reduced tyrosine hydroxylase expression in the FucM mutant
Regulation (mutant) of Gene_expression (expression) of tyrosine hydroxylase
5) Confidence 0.33 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.09 Pain Relevance 0
Analysis of c-Fos, pTH, TH, and pDARPP-32 immunoreactivity
Regulation (immunoreactivity) of Gene_expression (Analysis) of pTH
6) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.03
Analysis of c-Fos, pTH, TH, and pDARPP-32 immunoreactivity
Regulation (immunoreactivity) of Gene_expression (Analysis) of TH
7) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.03
The differences seen in c-Fos expression compared to pTH and pDARPP-32 expression also indicate that dopamine may not be the only player influencing neglect.
Regulation (seen) of Gene_expression (expression) of pTH associated with dopamine
8) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.07 Pain Relevance 0.65
To control for changes in TH expression in atrophic neurons, NeuN+ cell bodies in the SNc were counted in exactly the same manner as described above with reference to adjacent TH-immunostained sections from the same animal.
Regulation (changes) of Gene_expression (expression) of TH in neurons
9) Confidence 0.27 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0 Pain Relevance 0.07
One other explanation for this loss of nigral dopaminergic neurons could be the down regulation of TH expression in the dopaminergic cells.
Regulation (regulation) of Gene_expression (expression) of TH in dopaminergic neurons
10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808242 Disease Relevance 0.48 Pain Relevance 0.14
The level of TH mRNAs in the N2a-R?
Regulation (level) of Gene_expression (mRNAs) of TH
11) Confidence 0.21 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.06 Pain Relevance 0.12
Using in situ hybridization and immunohistochemistry, we have studied changes in the expression of neuropeptides, acetylcholinesterase and tyrosine hydroxylase in CD1 and FVB wild-type mouse strains, as well as in PrP(C) null mice and in mice overexpressing PrP(C) following intracerebral inoculation with RML or Me7 prions.
Regulation (changes) of Gene_expression (expression) of tyrosine hydroxylase associated with neuropeptide and sprains and strains
12) Confidence 0.16 Published 2007 Journal Neurobiol. Aging Section Abstract Doc Link 16621165 Disease Relevance 0.28 Pain Relevance 0.43
2000;) to control for changes in TH protein expression.
Regulation (control) of Gene_expression (expression) of TH
13) Confidence 0.16 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0 Pain Relevance 0.03
2000;) to control for changes in TH protein expression.
Regulation (changes) of Gene_expression (expression) of TH
14) Confidence 0.16 Published 2010 Journal Parkinson's Disease Section Body Doc Link PMC2951138 Disease Relevance 0 Pain Relevance 0.03
Tyrosine hydroxylase expression is unaltered in VTA and substantia nigra whereas tyrosine hydroxylase and ?
Regulation (unaltered) of Gene_expression (expression) of Tyrosine hydroxylase in substantia nigra associated with substantia nigra and midbrain
15) Confidence 0.05 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.93 Pain Relevance 0.50

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