INT102902

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 152
Total Number 155
Disease Relevance 81.52
Pain Relevance 39.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 31
brain 18
dorsal horn 4
sensory neurons 3
nociceptor 3
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 2786 100.00 Very High Very High Very High
Nerve growth factor 373 100.00 Very High Very High Very High
agonist 289 100.00 Very High Very High Very High
qutenza 211 100.00 Very High Very High Very High
fluoxetine 439 99.98 Very High Very High Very High
dorsal root ganglion 557 99.96 Very High Very High Very High
nociceptor 1384 99.84 Very High Very High Very High
Eae 203 99.72 Very High Very High Very High
antidepressant 1738 99.70 Very High Very High Very High
Hippocampus 1066 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4067 100.00 Very High Very High Very High
Congenital Anomalies 225 100.00 Very High Very High Very High
Targeted Disruption 2279 99.96 Very High Very High Very High
Sprains And Strains 82 99.96 Very High Very High Very High
Repression 335 99.92 Very High Very High Very High
Suicidal Behaviour 2834 99.88 Very High Very High Very High
Anxiety Disorder 399 99.64 Very High Very High Very High
INFLAMMATION 380 99.64 Very High Very High Very High
Depression 2329 99.44 Very High Very High Very High
Neurodegenerative Disease 302 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that neurons from a mouse model of neurodegeneration over-express trkB.T1, resulting in a significant increase in resting intracellular calcium; reducing trkB.T1 expression in those neurons reduced intracellular calcium to wildtype levels [23].
Gene_expression (express) of trkB in neurons
1) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.45 Pain Relevance 0.41
Moreover, altered trkB.T1 expression can affect synaptic plasticity.
Gene_expression (expression) of trkB
2) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.19
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Gene_expression (expression) of trkB in brain
3) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.19
In addition to trkB.FL, the Ntrk2 (trkB) locus encodes for several alternatively-spliced isoforms of the receptor [15], including trkB.T1, the predominant isoform expressed in the adult mammalian nervous system.
Gene_expression (expressed) of trkB in nervous system
4) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.56 Pain Relevance 0.29
Over-expression of trkB.T1 in hippocampal neurons leads to the inhibition of synaptic potentiation [34] and over-expressing trkB.T1 at neuromuscular synapses results in disassembly of acetylcholine receptor clustering [18].
Gene_expression (expression) of trkB in neurons
5) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.79 Pain Relevance 0.26
For example, neurons express both isoforms [33] while astrocytes only express trkB.T1 [23,40].
Gene_expression (express) of trkB in astrocytes
6) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.35
Next, we asked whether genetic deletion of trkB.T1 would provide a benefit for mice treated with capsaicin, an agonist of TRPV1 receptors that are expressed in BDNF-immunoreactive nociceptors.
Gene_expression (expressed) of trkB in nociceptors associated with qutenza, nociceptor and agonist
7) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.96 Pain Relevance 0.65
Over-expression of trkB.T1 in hippocampal neurons leads to the inhibition of synaptic potentiation [34] and over-expressing trkB.T1 at neuromuscular synapses results in disassembly of acetylcholine receptor clustering [18].
Gene_expression (expressing) of trkB in synapses
8) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.81 Pain Relevance 0.29
Thus, our results demonstrating attenuation in thermal and mechanical sensitivity in the absence of trkB.T1 could be because increased trkB.T1 expression induces increased intracellular calcium signaling which promotes hypersensitivity.
Gene_expression (expression) of trkB associated with hypersensitivity
9) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.73 Pain Relevance 0.43
Noxious stimulation increases BDNF and trkB.FL production in the spinal dorsal horn [5-9] and brainstem [10,11], leading to hyperalgesia and the formation of nocifensive behaviors.
Gene_expression (production) of trkB in dorsal horn associated with medulla, hyperalgesia and spinal dorsal horn
10) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.59 Pain Relevance 0.38
We have shown that neurons from a mouse model of neurodegeneration over-express trkB.T1, resulting in a significant increase in resting intracellular calcium; reducing trkB.T1 expression in those neurons reduced intracellular calcium to wildtype levels [23].
Gene_expression (expression) of trkB in neurons
11) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.47 Pain Relevance 0.41
The prevailing view has been that trkB.T1 expression leads to dominant negative inhibition of full-length trkB signaling and a reduction in the activation of downstream signaling molecules [17-23,33].
Gene_expression (expression) of trkB
12) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.68 Pain Relevance 0.34
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Gene_expression (expression) of trkB in brain
13) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.63 Pain Relevance 0.20
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Gene_expression (expression) of trkB in brain
14) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.19
The expression of trkB.FL and trkB.T1 is conserved across species and throughout evolution, and trkB isoform expression is regulated during development when the dominant trkB isoform expression in the brain switches from trkB.FL to trkB.T1 [39].
Gene_expression (expression) of trkB in brain
15) Confidence 0.78 Published 2009 Journal Mol Pain Section Body Doc Link PMC2777863 Disease Relevance 0.66 Pain Relevance 0.25
Transgenic mice overexpressing the full-length trkB receptor (TrkB.TK+) and showing increased trkB activity in brain, and their wild type (WT) littermates, were injected with the antidepressant fluoxetine or saline, and analyzed behaviorally in the forced swimming test paradigm and biochemically for the concentrations of brain monoamines and their metabolites. 4.
Spec (analyzed) Gene_expression (overexpressing) of trkB in brain associated with targeted disruption, antidepressant, monoamine and fluoxetine
16) Confidence 0.78 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.19 Pain Relevance 0.50
We have previously shown that the antidepressants imipramine and fluoxetine produce a rapid autophosphorylation of TrkB in the rodent brain.
Gene_expression (produce) of TrkB in brain associated with antidepressant and fluoxetine
17) Confidence 0.77 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17314919 Disease Relevance 0 Pain Relevance 0.47
T48 and T62 cells, stably transfected with rat TrkB in SN56 cells were cultured in the same medium containing 300 µg/ml G418 [19].
Gene_expression (transfected) of TrkB
18) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.27 Pain Relevance 0.07
T48 cells are TrkB stably transfected SN56 cells.
Gene_expression (transfected) of TrkB
19) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.55 Pain Relevance 0.12
Numerous compounds selectively protected TrkB expressing T48, but not parental SN56 cells lacking TrkB from Staurosporine-initiated apoptosis.
Gene_expression (expressing) of TrkB associated with apoptosis
20) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.37 Pain Relevance 0.14

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