INT102903

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 7
Speculated 7
Reported most in Body
Documents 35
Total Number 42
Disease Relevance 20.10
Pain Relevance 17.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 18
brain 6
neuronal 4
SCN 4
amygdala 2
Bdnf (Mus musculus)
Bdnf - V66M (1)
Pain Link Frequency Relevance Heat
antidepressant 1575 100.00 Very High Very High Very High
fluoxetine 433 100.00 Very High Very High Very High
bDMF 39 100.00 Very High Very High Very High
Locus ceruleus 3 99.74 Very High Very High Very High
Hippocampus 1045 99.68 Very High Very High Very High
tetrodotoxin 16 99.56 Very High Very High Very High
depression 1783 99.40 Very High Very High Very High
cytokine 24 99.28 Very High Very High Very High
midbrain 73 99.20 Very High Very High Very High
Desipramine 238 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 2830 99.84 Very High Very High Very High
Stress 600 99.82 Very High Very High Very High
Retts Disease 39 99.44 Very High Very High Very High
Depression 2335 99.40 Very High Very High Very High
Urological Neuroanatomy 391 99.16 Very High Very High Very High
Neurological Disease 6 98.60 Very High Very High Very High
Targeted Disruption 186 98.16 Very High Very High Very High
Disease 25 95.88 Very High Very High Very High
Substance Withdrawal Syndrome 2 93.88 High High
Neurodegenerative Disease 82 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This polymorphism is located 229 bp upstream from the transcription starting site of exon 1 and is not considered to have an effect on the expression of the BDNF gene.
Regulation (effect) of Gene_expression (expression) of BDNF
1) Confidence 0.62 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.40 Pain Relevance 0.37
To examine how BDNF is regulated in response to antidepressants, we administered different classes of antidepressants (serotonin uptake blocker, fluoxetine, norepinephrine blocker, desipramine, monoamine oxidase inhibitor, or phenelzine) to healthy rats and examined whether antidepressants regulate the expression of BDNF via specific BDNF transcript(s).92 We observed very interesting results such that treatment of healthy rats with desipramine or phenelzine increased mRNA levels of total BDNF in both the frontal cortex and hippocampus, whereas fluoxetine increased the mRNA level of BDNF only in the hippocampus.92 More interestingly, when we examined the effects of antidepressants on the expression of individual exons containing BDNF transcripts, we found that desipramine specifically increased exons I and III in both the frontal cortex and hippocampus; fluoxetine increased only exon II in the hippocampus; and phenelzine effectively increased exons I and IV in the hippocampus but only exon I in the frontal cortex.
Spec (whether) Regulation (regulate) of Gene_expression (expression) of BDNF in hippocampus associated with desipramine, antidepressant, urological neuroanatomy, hippocampus, serotonin, monoamine and fluoxetine
2) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.30 Pain Relevance 1.31
Although the previous studies did not find sex-specific changes in BDNF expression in the hippocampus or cortical areasb,181,182 whether sex-specific effect in BDNF expression is specific to the midbrain area needs further studies.
Regulation (effect) of Gene_expression (expression) of BDNF in hippocampus associated with midbrain and hippocampus
3) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.98 Pain Relevance 0.27
Studies in pre-clinical models have shown stress-induced dysregulation of BDNF expression.
Regulation (dysregulation) of Gene_expression (expression) of BDNF associated with stress
4) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.34 Pain Relevance 0.31
The effects of antidepressants on the expression of the Bdnf gene have been investigated extensively.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of Bdnf gene associated with antidepressant
5) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.52 Pain Relevance 0.62
They found that BDNF level was much lower in the midbrain (nonpreganglionic Edinger-Westphal nucleus) of male suicide subjects, whereas female suicide subjects showed an increased level of BDNF in this brain area, suggesting a possible sex effect in the regulation of BDNF expression in suicide subjects.
Regulation (regulation) of Gene_expression (expression) of BDNF in Edinger-Westphal nucleus associated with suicidal behaviour and midbrain
6) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.09 Pain Relevance 0.30
Regulation of BDNF expression by antidepressants
Regulation (Regulation) of Gene_expression (expression) of BDNF associated with antidepressant
7) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.53 Pain Relevance 0.57
Plasmin is the major extracellular protease that cleaves pro-BDNF.60,61 The expression of the BDNF gene is tightly regulated by neuronal activity, through mechanisms dependent on calcium.62 In addition to BDNF, the function of a receptor for BDNF (ie, TrkB) is also regulated in an activity-dependent manner.
Regulation (regulated) of Gene_expression (expression) of BDNF gene in neuronal
8) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.12 Pain Relevance 0.03
However, no effect of fluoxetine on total BDNF expression was observed in the frontal cortex, because fluoxetine was not able to increase either exon II or IV in the frontal cortex.
Neg (no) Regulation (effect) of Gene_expression (expression) of BDNF in frontal cortex associated with urological neuroanatomy and fluoxetine
9) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.56 Pain Relevance 0.89
Although the biological significance of these BDNF transcripts is not clear, it appears that these transcripts can facilitate multi-level regulation of BDNF expression and may determine the tissue-specific expression.
Regulation (regulation) of Gene_expression (expression) of BDNF
10) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.35 Pain Relevance 0.20
These include indirect evidence demonstrating that antidepressants regulate BDNF/TrkB expression and that BDNF itself shows antidepressant-like effects.
Regulation (regulate) of Gene_expression (expression) of BDNF associated with antidepressant
11) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.59 Pain Relevance 0.43
Interestingly, no significant change in BDNF protein expression was observed in the hippocampus.
Neg (no) Regulation (change) of Gene_expression (expression) of BDNF in hippocampus associated with hippocampus
12) Confidence 0.61 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.04 Pain Relevance 0.24
Our results demonstrate a different regulation of BDNF expression by antidepressant drugs in the hippocampus of Wt and TG animals.
Regulation (regulation) of Gene_expression (expression) of BDNF in hippocampus associated with targeted disruption, antidepressant and hippocampus
13) Confidence 0.60 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555640 Disease Relevance 0.62 Pain Relevance 0.95
To examine the time-dependent changes in BDNF expression, we performed immunohistostaining (Figure 4).
Spec (examine) Regulation (changes) of Gene_expression (expression) of BDNF
14) Confidence 0.53 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2664844 Disease Relevance 0 Pain Relevance 0
In general, an increase in BDNF expression occurs only after long-term treatment and, in most cases, short-term treatment with antidepressants causes no change in the expression of BDNF.98,101,106,117,118 However, short-term treatment with antidepressants has also been shown to cause an increase in BDNF expression in the cortex119,120 and even a decrease in the hippocampus.101,119,120
Neg (no) Regulation (change) of Gene_expression (expression) of BDNF in hippocampus associated with antidepressant and hippocampus
15) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.16 Pain Relevance 0.80
Although it is difficult to assess the extent of involvement of a particular exon in regulation of overall BDNF expression, there is complete reversal by desipramine in both the frontal cortex and hippocampus because the increase in exon III was very robust in these brain areas.
Regulation (regulation) of Gene_expression (expression) of BDNF in brain associated with desipramine, urological neuroanatomy and hippocampus
16) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.63 Pain Relevance 0.94
Although some of these discrepancies can be attributed to route of administration or doses of drugs, these findings suggest that there is no unified mechanism for the regulation of BDNF exon(s) by antidepressants and that various classes of antidepressants may affect BDNF exon expression differently.
Spec (may) Regulation (affect) of Gene_expression (expression) of BDNF associated with antidepressant
17) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.38 Pain Relevance 0.94
Several studies have shown that exposure of exogenous corticosterone (to mimic the stress effect) also reduces BDNF expression in rodent hippocampus, similar to that observed in various pre-clinical stress models.83,89–91 Recently, we examined the effects of corticosterone treatment on BDNF expression in detail and found that the mRNA level of BDNF was not only decreased in the hippocampus but that the frontal cortex also showed significantly reduced expression of BDNF.92 This suggests that the effects of glucocorticoids on BDNF are not limited to the hippocampus; other brain areas are also equally affected.
Spec (examined) Regulation (effects) of Gene_expression (expression) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
18) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.62 Pain Relevance 0.39
In addition, depressed patients show alterations in expression of BDNF both in blood cells and in postmortem brain tissues.
Regulation (alterations) of Gene_expression (expression) of BDNF in brain
19) Confidence 0.53 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.57 Pain Relevance 0.51
One locus with prominent changes is BDNF, and in conjunction with the suggestion of BDNF as a potential target for design of new antidepressants, the epigenetic control of BDNF expression has been extensively analyzed in the context of the expression of depression and chronic antidepressant treatments.
Regulation (control) of Gene_expression (expression) of BDNF associated with antidepressant, depression and bdmf
20) Confidence 0.51 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.52 Pain Relevance 0.69

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