INT102908

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.42
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk2b) cytosol (Camk2b) cytoskeleton (Camk2b)
microtubule organizing center (Camk2b) cytoplasm (Camk2b)
Anatomy Link Frequency
neurons 1
synapses 1
hippocampus 1
Camk2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 1 99.40 Very High Very High Very High
Hippocampus 2 98.46 Very High Very High Very High
qutenza 4 96.44 Very High Very High Very High
spinal dorsal horn 14 95.60 Very High Very High Very High
central sensitization 5 91.64 High High
long-term potentiation 33 91.24 High High
Spinal cord 4 87.92 High High
nMDA receptor 4 87.84 High High
c fibre 8 81.24 Quite High
Inflammation 1 79.20 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 97.48 Very High Very High Very High
Injury 1 79.68 Quite High
INFLAMMATION 1 79.20 Quite High
Anaerobic Bacterial Infections 2 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate an increased expression and phosphorylation of CaMK II in rat spinal dorsal horn neurons after noxious stimulation by intradermal injection of capsaicin.
Phosphorylation (phosphorylation) of CaMK II in neurons associated with qutenza and dorsal horn neuron
1) Confidence 0.62 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12019337 Disease Relevance 0.42 Pain Relevance 0.63
Phosphorylated CaMK II potentiates synaptic transmission by enhancement of AMPA receptor channel function via phosphorylation of GluR1 subunit of the receptor and the addition of AMPA receptors to synapses.
Phosphorylation (Phosphorylated) of CaMK II in synapses
2) Confidence 0.55 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.80
In the hippocampus, a rise of Ca(2+) activates calcium/calmodulin-dependent protein kinase II (CaMK II) through autophosphorylation.
Phosphorylation (autophosphorylation) of CaMK II in hippocampus associated with hippocampus
3) Confidence 0.48 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0 Pain Relevance 0.75

General Comments

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