INT102927

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 51.60 Quite High
anesthesia 2 25.00 Low Low
bradykinin 5 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypotension 3 99.52 Very High Very High Very High
Death 3 95.36 Very High Very High Very High
Myocardial Infarction 47 94.92 High High
Heart Rate Under Development 2 89.96 High High
Increased Venous Pressure Under Development 8 83.76 Quite High
Chronic Renal Failure 1 61.72 Quite High
Hypertension 1 59.64 Quite High
Left Ventricular Dysfunction 4 50.00 Quite Low
Ventricular Remodeling 1 39.84 Quite Low
Coronary Heart Disease 1 32.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that Bulbus Fritillaria extracts have a hypotensive effect in rats via the inhibition of ACE activity and direct release of NO/cGMP in the vascular tissue.
Negative_regulation (inhibition) of Localization (release) of ACE associated with hypotension
1) Confidence 0.58 Published 2002 Journal J Ethnopharmacol Section Abstract Doc Link 12020927 Disease Relevance 0.24 Pain Relevance 0
These results suggest that berberine has a hypotensive effect, at least in part, via the inhibition of ACE and direct release of NO/cGMP in the vascular tissues.
Negative_regulation (inhibition) of Localization (release) of ACE associated with hypotension
2) Confidence 0.57 Published 2002 Journal Vascul. Pharmacol. Section Abstract Doc Link 14567065 Disease Relevance 0.10 Pain Relevance 0
In a subset analysis, 366 patients who were not receiving ACE inhibitors were randomly assigned to either valsartan or placebo.
Neg (not) Negative_regulation (inhibitors) of Neg (not) Localization (receiving) of ACE
3) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.66 Pain Relevance 0.03

General Comments

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