INT102964

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 5.58
Pain Relevance 9.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
Anatomy Link Frequency
neurons 7
spinal 4
nervous system 2
spinal cord 1
ganglia 1
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 195 100.00 Very High Very High Very High
Glutamate receptor 83 100.00 Very High Very High Very High
mu opioid receptor 37 100.00 Very High Very High Very High
opioid receptor 21 100.00 Very High Very High Very High
central sensitization 63 99.76 Very High Very High Very High
Immobilon 8 99.28 Very High Very High Very High
Pain 276 99.16 Very High Very High Very High
IPN 63 99.12 Very High Very High Very High
Kinase C 127 99.06 Very High Very High Very High
Hippocampus 100 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 307 99.56 Very High Very High Very High
Pain 279 99.16 Very High Very High Very High
Inflammatory Pain 72 99.12 Very High Very High Very High
Ganglion Cysts 111 98.14 Very High Very High Very High
Repression 3 93.28 High High
Neuropathic Pain 60 85.12 High High
Migraine Disorders 130 84.88 Quite High
INFLAMMATION 73 79.04 Quite High
Depression 179 78.44 Quite High
Stress 6 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that repeated s.c. treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors.
Phosphorylation (phosphorylation) of receptors in spinal cord associated with kinase c, mu opioid receptor, opioid receptor, spinal cord, morphine and immobilon
1) Confidence 0.04 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.26
The increased affinity of opioid receptors has been previously shown to result from a decrease of phosphorylation, oligomerization and allosterism of opioid receptors [45].
Phosphorylation (phosphorylation) of receptors associated with opioid receptor
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.08 Pain Relevance 0.70
The increased affinity of opioid receptors has been previously shown to result from a decrease of phosphorylation, oligomerization and allosterism of opioid receptors [45].
Phosphorylation (phosphorylation) of receptors associated with opioid receptor
3) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017033 Disease Relevance 0.08 Pain Relevance 0.63
In addition, within the nervous system, regulation of NMDA receptors through ephrin-B2 induced phosphorylation has been described [31].
Phosphorylation (phosphorylation) of receptors in nervous system associated with nmda receptor
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.75 Pain Relevance 1.09
We next wanted to know whether the phosphorylation of NMDA receptors was modified in TgDREAM hippocampus.
Phosphorylation (phosphorylation) of receptors in hippocampus associated with nmda receptor and hippocampus
5) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.16 Pain Relevance 0.61
First, expression or phosphorylation of NMDA receptors may be altered in TgDREAM mice.
Phosphorylation (phosphorylation) of receptors associated with nmda receptor
6) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.61 Pain Relevance 0.90
Phosphorylation of NMDA receptors is important for their synaptic functions [47,48].
Phosphorylation (Phosphorylation) of receptors associated with nmda receptor
7) Confidence 0.01 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.17 Pain Relevance 0.58
R192Q KI neurons lack constitutive serine phosphorylation of P2X3 receptors
Phosphorylation (phosphorylation) of receptors in neurons
8) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
We observed that, under unchallenged conditions, the basal phosphorylation state of threonine and tyrosine in P2X3 receptors of KI neurons was unchanged compared with WT neurons.
Phosphorylation (phosphorylation) of receptors in neurons
9) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.16 Pain Relevance 0.13
Future experiments are necessary to identify the mechanisms regulating the basal serine phosphorylation of P2X3 receptors of WT cells.


Phosphorylation (phosphorylation) of receptors
10) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.07 Pain Relevance 0.07
Future studies will be necessary to clarify this complex scenario in which multiple pathways control the phosphorylation state of P2X3 receptors with important and differential outcomes in terms of function and thus, presumably, in terms of pain sensing efficiency.


Phosphorylation (phosphorylation) of receptors associated with pain
11) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.32 Pain Relevance 0.32
Although no significant difference in membrane expression of knockin receptors was found, serine phosphorylation of knockin P2X3 receptors was constitutively decreased and restored by KN-93.
Phosphorylation (phosphorylation) of receptors
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.54 Pain Relevance 0.39
However, we did observe decreased serine phosphorylation of P2X3 receptors as the molecular phenotype of CaV2.1-immunoreactive neurons in KI ganglia and in culture.
Phosphorylation (phosphorylation) of receptors in ganglia
13) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.14 Pain Relevance 0.11
The present results suggest that the CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin that selectively impaired the serine phosphorylation state of such receptors, thus potentiating their effects in transducing trigeminal nociception.



Phosphorylation (phosphorylation) of receptors in neurons associated with nociception, ganglion cysts and trigeminal ganglion neurons
14) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2940876 Disease Relevance 0.40 Pain Relevance 0.15
The observation of strong CaMKII activation in KI neurons led us to examine the phosphorylation state of their P2X3 receptors.
Spec (examine) Phosphorylation (phosphorylation) of receptors in neurons
15) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
These results suggest that R192Q mutation in CaV2.1 channels conferred to KI trigeminal neurons a molecular phenotype with constitutively depressed serine phosphorylation of P2X3 receptors, together with upregulation of P2X3 receptor-mediated currents.
Phosphorylation (phosphorylation) of receptors in neurons
16) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0 Pain Relevance 0
The phosphorylation state of P2X3 receptors is important to control ATP-mediated responses of nociceptive neurons
Phosphorylation (phosphorylation) of receptors in neurons associated with nociception
17) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.25 Pain Relevance 0.22
G protein-coupled receptor kinases (GRKs) phosphorylate opioid receptors, which eventually results in receptor sequestration.
Phosphorylation (phosphorylate) of receptors associated with opioid receptor
18) Confidence 0.01 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.21
The phosphorylation of membrane receptors is an important post-translational mechanism underlying synaptic plasticity in nervous systems as well as in pain modulation.
Phosphorylation (phosphorylation) of receptors in nervous systems associated with pain
19) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.36 Pain Relevance 0.49
Strong noxious stimulation in the periphery tissues may activate several protein kinase cascades, such as CaMKII, PKA, PKC, and PKG, which play an important role in the phosphorylation of glutamate receptors in spinal nociceptive neurons [23,28-30].
Phosphorylation (phosphorylation) of receptors in spinal associated with nociception, kinase c and glutamate receptor
20) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.26 Pain Relevance 0.46

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