INT102969

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.21
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
Anatomy Link Frequency
embryonic kidney 2
C cells 2
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 33 99.04 Very High Very High Very High
melanocortin 1 receptor 12 98.20 Very High Very High Very High
Enkephalin 1 95.40 Very High Very High Very High
mu opioid receptor 5 93.84 High High
Kinase C 6 92.08 High High
opioid receptor 6 86.76 High High
tolerance 3 85.52 High High
Kappa opioid receptor 3 75.00 Quite High
Opioid 2 75.00 Quite High
Antinociceptive 1 73.20 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 10 100.00 Very High Very High Very High
Neuroblastoma 11 89.96 High High
Hyperalgesia 1 71.32 Quite High
Dysmenorrhea 1 62.92 Quite High
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prolonged (24 h) activation of the mu receptor desensitized both mu and ORL1 receptor-mediated inhibition of forskolin-stimulated cAMP accumulation and upregulated GRK2 levels in SH-SY5Y and BE(2)-C cells.
Positive_regulation (upregulated) of Gene_expression (levels) of GRK2 in C cells
1) Confidence 0.46 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12423667 Disease Relevance 0.09 Pain Relevance 0.30
In COS-7 cells, which express low levels of GRK2 and beta-arrestin, overexpression of GRK2 and beta-arrestin increased receptor phosphorylation, desensitization, and internalization to the high levels observed in human embryonic kidney 293 cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GRK2 in embryonic kidney
2) Confidence 0.45 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 14976224 Disease Relevance 0.06 Pain Relevance 0.13
Cotransfection of the receptor and GRK2 or GRK6 genes in heterologous cells demonstrated that GRK2 and GRK6 impair agonist-dependent signaling by MC1R or Mc1r.
Positive_regulation (Cotransfection) of Gene_expression (Cotransfection) of GRK2 associated with melanocortin 1 receptor and agonist
3) Confidence 0.43 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15650023 Disease Relevance 0.41 Pain Relevance 0.74
Expression of a dominant negative GRK2 mutant in melanoma cells increased their cAMP response to agonists.
Positive_regulation (increased) of Gene_expression (Expression) of GRK2 associated with agonist and skin cancer
4) Confidence 0.43 Published 2005 Journal Mol. Endocrinol. Section Abstract Doc Link 15650023 Disease Relevance 0.42 Pain Relevance 0.77
Comparing the effect of over-expressed GRK2 and GRK3 on sequestration of kappa-receptors, we conclude that GRK3 more strongly induces kappa-receptor internalization than GRK2.
Positive_regulation (over-expressed) of Gene_expression (expressed) of GRK2
5) Confidence 0.41 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.15
However, DAMGO (1 microM) pretreatment increased membrane levels of GRK2 and GRK3, indicating their translocation to the membrane upon activation.
Positive_regulation (increased) of Gene_expression (levels) of GRK2
6) Confidence 0.38 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.78
2A-AR prompts enhanced expression of GRK3, but not GRK2, in whole cells [15] and membrane fractions.
Positive_regulation (enhanced) of Gene_expression (expression) of GRK2
7) Confidence 0.23 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0

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