INT102970

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Context Info
Confidence 0.66
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.45
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ADRBK1) signal transduction (ADRBK1) aging (ADRBK1)
plasma membrane (ADRBK1) cytoplasm (ADRBK1)
Anatomy Link Frequency
vesicles 1
EPI 1
ADRBK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 99.14 Very High Very High Very High
mu opioid receptor 10 95.36 Very High Very High Very High
Enkephalin 2 94.24 High High
Opioid 3 90.24 High High
Kinase C 2 86.88 High High
opioid receptor 9 77.32 Quite High
Kappa opioid receptor 3 75.00 Quite High
Antinociceptive 2 72.04 Quite High
Hyperalgesia 2 70.16 Quite High
analgesia 2 69.48 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 12 92.40 High High
Hyperalgesia 2 70.16 Quite High
Aids-related Complex 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Hypertension 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The agonist-occupied human kappa-receptor also causes translocation of GRK2- and GRK3-DsRed, which was followed by the formation of vesicles carrying the green fluorescent kappa-receptors.
Localization (translocation) of GRK2 in vesicles associated with agonist
1) Confidence 0.66 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 12021406 Disease Relevance 0 Pain Relevance 0.30
However, DAMGO (1 microM) pretreatment increased membrane levels of GRK2 and GRK3, indicating their translocation to the membrane upon activation.
Localization (translocation) of GRK2
2) Confidence 0.61 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.80
Antisense, but not sense, DNA selectively targeting GRK2 or GRK3 blocks DAMGO-mediated mu- and ORL1 desensitization, respectively.
Localization (targeting) of GRK2
3) Confidence 0.61 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12750434 Disease Relevance 0.22 Pain Relevance 0.76
First chronic EPI treatment enhances localization of GRK2 and GRK3 to the membrane.
Localization (localization) of GRK2 in EPI
4) Confidence 0.36 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2234403 Disease Relevance 0 Pain Relevance 0

General Comments

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