INT102979

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 4.95
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pecam1) cell adhesion (Pecam1) plasma membrane (Pecam1)
Anatomy Link Frequency
coronary artery 2
blood vessels 2
endothelial cell 2
capillary 2
Pecam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 14 100.00 Very High Very High Very High
Inflammation 11 99.68 Very High Very High Very High
adenocard 4 99.54 Very High Very High Very High
ischemia 8 99.24 Very High Very High Very High
cytokine 2 98.34 Very High Very High Very High
Cannabinoid receptor 3 96.68 Very High Very High Very High
Endocannabinoid 9 94.84 High High
agonist 2 92.24 High High
Angina 1 91.48 High High
anesthesia 2 65.20 Quite High
Disease Link Frequency Relevance Heat
Cancer 86 100.00 Very High Very High Very High
Adhesions 6 100.00 Very High Very High Very High
Htlv Types I And Ii 8 99.88 Very High Very High Very High
Spinal Cord Ischemia 6 99.72 Very High Very High Very High
INFLAMMATION 9 99.68 Very High Very High Very High
Hepatocellular Cancer 73 99.08 Very High Very High Very High
Reperfusion Injury 2 96.52 Very High Very High Very High
Paralysis 2 93.68 High High
Cv General 3 Under Development 1 91.48 High High
Myocardial Infarction 1 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We hypothesized that ATL-146e reduces cytokine production during spinal cord reperfusion, curtailing inflammation and decreasing spinal cord capillary platelet-endothelial cell adhesion molecule-1 (PECAM-1) expression.
Negative_regulation (decreasing) of Gene_expression (expression) of PECAM-1 in capillary associated with inflammation, htlv types i and ii, adhesions, spinal cord and cytokine
1) Confidence 0.40 Published 2002 Journal J. Vasc. Surg. Section Abstract Doc Link 12021717 Disease Relevance 1.36 Pain Relevance 0.82
Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia.
Negative_regulation (reduces) of Gene_expression (expression) of platelet-endothelial cell adhesion molecule-1 in endothelial cell associated with adenocard, cancer, ischemia, htlv types i and ii, adhesions and spinal cord
2) Confidence 0.35 Published 2002 Journal J. Vasc. Surg. Section Title Doc Link 12021717 Disease Relevance 1.36 Pain Relevance 0.79
Moreover, angiogenesis was evaluated by the measurement of both hemoglobin content and CD31 protein expression.
Negative_regulation (measurement) of Gene_expression (expression) of CD31
3) Confidence 0.32 Published 2010 Journal Pharmacol. Res. Section Abstract Doc Link 19931394 Disease Relevance 0.57 Pain Relevance 0.51
Preconditioning with sevoflurane decreases PECAM-1 expression and improves one-year cardiovascular outcome in coronary artery bypass graft surgery.
Negative_regulation (decreases) of Gene_expression (expression) of PECAM-1 in coronary artery
4) Confidence 0.16 Published 2005 Journal Br J Anaesth Section Title Doc Link 15556966 Disease Relevance 0.18 Pain Relevance 0.09
Interestingly, the number of PECAM-1-positive blood vessels was also decreased in epirubicin-treated HCC (Figure 6c).
Negative_regulation (decreased) of Gene_expression (blood vessels) of PECAM-1-positive in blood vessels associated with hepatocellular cancer
5) Confidence 0.10 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2918526 Disease Relevance 1.47 Pain Relevance 0

General Comments

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