INT102987

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 9.35
Pain Relevance 9.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
T-cell 2
joint 1
synovial fluid 1
blood 1
cartilage 1
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 858 100.00 Very High Very High Very High
spinal inflammation 168 100.00 Very High Very High Very High
Inflammatory mediators 5 100.00 Very High Very High Very High
Arthritis 216 99.52 Very High Very High Very High
antagonist 2 99.48 Very High Very High Very High
Osteoarthritis 113 99.28 Very High Very High Very High
Inflammation 146 98.68 Very High Very High Very High
cINOD 33 97.86 Very High Very High Very High
rheumatoid arthritis 63 97.64 Very High Very High Very High
Pain 48 95.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Low Back Pain 171 100.00 Very High Very High Very High
INFLAMMATION 170 100.00 Very High Very High Very High
Disease 147 99.78 Very High Very High Very High
Juvenile Chronic Polyarthritis 180 99.52 Very High Very High Very High
Cancer 118 99.36 Very High Very High Very High
Osteoarthritis 89 99.28 Very High Very High Very High
Necrosis 38 99.12 Very High Very High Very High
Experimental Arthritis 20 98.72 Very High Very High Very High
Transitional Cell Carcinoma 52 98.00 Very High Very High Very High
Rheumatoid Arthritis 63 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in patients with osteoarthritis: a pilot study.
Regulation (Effect) of stromelysin-1 associated with osteoarthritis
1) Confidence 0.60 Published 2004 Journal Int J Clin Pract Suppl Section Title Doc Link 16035398 Disease Relevance 0.38 Pain Relevance 0.47
Activated MMP1, MMP3 and latent forms of MMP2 and MMP9 are regulated and inhibited by endogenous proteins known as tissue inhibitors of metalloproteinase TIMP1 and TIMP2 [17].
Regulation (regulated) of MMP3 associated with metalloproteinase
2) Confidence 0.52 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.88 Pain Relevance 0.23
Prostaglandin E2, for instance, induces activation of MMP-3, but does not affect MMP-3 total protein in the rat cervix (Chien et al., 2005).
Neg (not) Regulation (affect) of MMP-3 in cervix associated with metalloproteinase
3) Confidence 0.47 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.05 Pain Relevance 0.19
A novel aspect of the present study is its evaluation of the effect of 5-Loxin® treatment on the cartilage degrading enzyme MMP-3 in synovial fluid from OA patients.
Regulation (effect) of MMP-3 in synovial fluid associated with osteoarthritis
4) Confidence 0.39 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575633 Disease Relevance 1.28 Pain Relevance 0.67
There were no significant differences in MMP-1 and MMP-3 concentrations between the groups (data not shown).


Neg (no) Regulation (differences) of MMP-3 associated with metalloproteinase
5) Confidence 0.39 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.06 Pain Relevance 0.85
Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
Regulation (effect) of MMP-3 associated with spinal inflammation and antagonist
6) Confidence 0.36 Published 2008 Journal Joint Bone Spine Section Title Doc Link 18674944 Disease Relevance 0.10 Pain Relevance 0.29
Nimesulide significantly reduced the serum levels of both HA and MMP-3, whereas ibuprofen increased moderately but significantly the serum concentrations of MMP-3 and had no effect on the serum concentrations of HA.
Neg (no) Regulation (effect) of MMP-3
7) Confidence 0.30 Published 2004 Journal Int J Clin Pract Suppl Section Abstract Doc Link 16035398 Disease Relevance 0.32 Pain Relevance 0.47
The non-parametric Brunner test was applied to compare changes in serum levels of VEGF, MMP-3, or BALP between AS and non-radiographic axial SpA patients by taking the baseline status of VEGF, MMP-3, or BALP into account.


Regulation (changes) of MMP-3 associated with spinal inflammation
8) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 0.37 Pain Relevance 0.38
No changes in serum levels of VEGF, MMP-3, and BALP in a tumor necrosis factor-alpha blocker-naïve cohort over a 2-year observation period
Regulation (changes) of MMP-3 associated with necrosis and cancer
9) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592815 Disease Relevance 0.32 Pain Relevance 0.12
The concentrations of MMP-1 and MMP-3 were generally low in all the samples.
Regulation (concentrations) of MMP-3 associated with metalloproteinase
10) Confidence 0.24 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.07 Pain Relevance 0.80
In this study the concentrations of MMP1, MMP2, MMP3, MMP9, their inhibitors TIMP1, TIMP2, and the MMP1/TIMP1-complex (MTC1) were quantified in blood plasma with the sandwich enzyme-linked immunosorbent assay (ELISA).
Regulation (concentrations) of MMP3 in blood
11) Confidence 0.23 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1560390 Disease Relevance 0.44 Pain Relevance 0.13
There were no significant changes in serum levels of MMP-3 (P > 0.05), VEGF (P > 0.05), and BALP (P > 0.05) in a large cohort of TNF-?
Regulation (changes) of MMP-3
12) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592815 Disease Relevance 0.83 Pain Relevance 0.65
This may suggest a disease-promoting role of MMP-3-specific T cells in JIA.
Regulation (role) of MMP-3-specific in T cells associated with metalloproteinase, disease and arthritis
13) Confidence 0.19 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.19 Pain Relevance 0.86
This prospective preliminary single-blind study was conducted in patients suffering from osteoarthritis (OA) and requiring non-steroidal anti-inflammatory drugs (NSAIDs) to determine to what extent nimesulide (200 mg/day) and ibuprofen (1200 mg/day) could induce significant changes in the serum levels of matrix metalloproteinase-3 (MMP-3), tissue inhibitor-1 of MMPs (TIMP-1), hyaluronan (HA) and YKL-40 after a therapeutic time period of 28 days.
Regulation (changes) of metalloproteinase-3 associated with inflammation, metalloproteinase, cinod and osteoarthritis
14) Confidence 0.16 Published 2004 Journal Int J Clin Pract Suppl Section Abstract Doc Link 16035398 Disease Relevance 0.37 Pain Relevance 0.47
This prospective preliminary single-blind study was conducted in patients suffering from osteoarthritis (OA) and requiring non-steroidal anti-inflammatory drugs (NSAIDs) to determine to what extent nimesulide (200 mg/day) and ibuprofen (1200 mg/day) could induce significant changes in the serum levels of matrix metalloproteinase-3 (MMP-3), tissue inhibitor-1 of MMPs (TIMP-1), hyaluronan (HA) and YKL-40 after a therapeutic time period of 28 days.
Regulation (changes) of MMP-3 associated with inflammation, metalloproteinase, cinod and osteoarthritis
15) Confidence 0.16 Published 2004 Journal Int J Clin Pract Suppl Section Abstract Doc Link 16035398 Disease Relevance 0.37 Pain Relevance 0.47
Reductions in serum YKL-40 and MMP-1 and 3 were nonsignificant, but significant correlations were observed between changes in BASDAI, ESR, CRP, and changes in serum levels of MMP-3 and YKL-40 (p < 0.005 to p < 0.05).
Regulation (changes) of MMP-3
16) Confidence 0.15 Published 2002 Journal J. Rheumatol. Section Body Doc Link 12022358 Disease Relevance 0 Pain Relevance 0
Recent studies identified MMP-3 as a target for T-cell recognition in both experimental arthritis and RA but also in age-matched healthy adult controls [27,32].
Regulation (target) of MMP-3 in T-cell associated with rheumatoid arthritis, metalloproteinase, experimental arthritis and arthritis
17) Confidence 0.11 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794523 Disease Relevance 1.25 Pain Relevance 0.79
in ASMC may not involve the participation of the p38 MAPK pathway, which is contrary to the regulation of MMP-3, -9 and -13 in articular chondrocytes and rat brain astrocytes [37,38].
Regulation (regulation) of MMP-3 in astrocytes associated with metalloproteinase
18) Confidence 0.11 Published 2005 Journal Respir Res Section Body Doc Link PMC1363355 Disease Relevance 0 Pain Relevance 0.43
As regards prognostic factors of joint destruction in the SAMURAI trial, the percentage change in matrix metalloproteinase-3 (MMP-3) at 12 weeks after starting treatment was an independent prognostic factor for the erosion score at 52 weeks by the modified Sharp method, and the percentage changes in CRP, MMP-3, and serum N-terminal propeptide of type II A collagen at 12 weeks after starting treatment have been reported to be significantly independent prognostic factors for the joint space narrowing (JSN) score (Hashimoto et al 2007).
Regulation (changes) of MMP-3 in joint associated with metalloproteinase
19) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0 Pain Relevance 0.07
In the cartilage, pentosan reduces cartilage degradation by directly and indirectly affecting inflammatory mediators such as MMP-3, IL-1 and TNF-alpha.
Regulation (affecting) of MMP-3 in cartilage associated with inflammatory mediators
20) Confidence 0.07 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2873929 Disease Relevance 0.69 Pain Relevance 0.35

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