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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 7.23
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CHI3L1) extracellular region (CHI3L1) endoplasmic reticulum (CHI3L1)
proteinaceous extracellular matrix (CHI3L1) carbohydrate metabolic process (CHI3L1) cytoplasm (CHI3L1)
Anatomy Link Frequency
plasma 2
cartilage 1
CHI3L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 96.68 Very High Very High Very High
Inflammatory marker 3 95.80 Very High Very High Very High
Inflammation 47 86.72 High High
tolerance 18 84.68 Quite High
Osteoarthritis 8 80.84 Quite High
spinal inflammation 5 50.00 Quite Low
Infliximab 3 50.00 Quite Low
Pain 1 46.20 Quite Low
cINOD 2 45.12 Quite Low
beta blocker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 9 100.00 Very High Very High Very High
Aids-related Complex 1 100.00 Very High Very High Very High
Coronary Artery Disease 76 99.58 Very High Very High Very High
Obesity 109 99.36 Very High Very High Very High
Insulin Resistance 10 97.96 Very High Very High Very High
INFLAMMATION 52 95.48 Very High Very High Very High
Diabetes Mellitus 115 91.08 High High
Calcification 93 86.04 High High
Impaired Glucose Tolerance 18 84.68 Quite High
Death 4 81.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to obtain further information about the regulation of systemic YKL-40, we examined plasma YKL-40 during hyperglycemic and hyperinsulinemic-euglycemic conditions.
Regulation (regulation) of YKL-40 in plasma
1) Confidence 0.48 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 1.97 Pain Relevance 0.29
There were no changes in plasma YKL-40 in healthy subjects during either hyperglycemic or hyperinsulinemic-euglycemic clamps.
Neg (no) Regulation (changes) of plasma YKL-40 in plasma
2) Confidence 0.48 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570404 Disease Relevance 1.32 Pain Relevance 0.14
Reductions in serum YKL-40 and MMP-1 and 3 were nonsignificant, but significant correlations were observed between changes in BASDAI, ESR, CRP, and changes in serum levels of MMP-3 and YKL-40 (p < 0.005 to p < 0.05).
Regulation (changes) of YKL-40
3) Confidence 0.19 Published 2002 Journal J. Rheumatol. Section Body Doc Link 12022358 Disease Relevance 0 Pain Relevance 0
Statin treatment in especially IHD patients could also influence the levels of both YKL-40 and hsCRP, but without this treatment we would expect even higher levels of both markers in the IHD groups.
Regulation (influence) of YKL-40 associated with coronary artery disease
4) Confidence 0.04 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.31 Pain Relevance 0.21
Finally, the regulation of the natural inhibitors of apoptosis (c-FLIP, BAR, ARC and HC-gp39) could complement the other strategies to reduce cartilage degradation.
Regulation (regulation) of HC-gp39 in cartilage associated with aids-related complex and apoptosis
5) Confidence 0.00 Published 2007 Journal Curr Drug Targets Section Abstract Doc Link 17305511 Disease Relevance 1.64 Pain Relevance 0.22

General Comments

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