INT103021

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 27
Disease Relevance 3.93
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Slc6a4) endosome (Slc6a4) transport (Slc6a4)
plasma membrane (Slc6a4)
Anatomy Link Frequency
retina 5
5-HT neurons 4
neurons 3
embryos 2
dorsal 1
Slc6a4 (Mus musculus)
Pain Link Frequency Relevance Heat
Raphe 96 99.04 Very High Very High Very High
Raphe magnus 24 99.00 Very High Very High Very High
Kinase C 15 99.00 Very High Very High Very High
medulla 180 97.16 Very High Very High Very High
fluoxetine 508 96.76 Very High Very High Very High
5HT 84 96.52 Very High Very High Very High
Serotonin 485 94.40 High High
antidepressant 99 92.40 High High
monoamine 31 78.40 Quite High
depression 46 75.68 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 17 99.54 Very High Very High Very High
Acidosis 684 97.44 Very High Very High Very High
Anxiety Disorder 7 94.48 High High
Handedness 144 83.92 Quite High
Pressure And Volume Under Development 1 81.32 Quite High
Death 24 79.48 Quite High
Sudden Infant Death Syndrome 72 78.44 Quite High
Depression 52 75.68 Quite High
Hypertension 5 75.00 Quite High
Rare Diseases 36 62.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific primers were designed to detect Sert mRNA in mouse embryonic retinas by quantitative RT–PCR (qRT–PCR).
Transcription (detect) of Sert in retinas
1) Confidence 0.70 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
It is generally believed that the s allele (or the ss genotype), associated with low levels of transcription of the SLC6A4, results in a desensitization of post synaptic 5-HT receptors, which in turn increase the risk for these disorders.
Transcription (transcription) of SLC6A4
2) Confidence 0.63 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.44 Pain Relevance 0.13
At E16.5, when the expression of Zic2 peaked in the VT retina, Sert mRNA also was expressed highly in a domain identical to that of Zic2.
Transcription (expressed) of Sert in retina
3) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
We therefore examined Sert mRNA expression at E16.5 in Zic2kd/kd and wild-type littermates when both Zic2 and Sert expression levels peak in the retina (Figure 2C).
Transcription (expression) of Sert in retina
4) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Together with previous results, this demonstrates that Zic2 determines the ipsilateral phenotype in the retinofugal pathway by regulating the transcription of at least two downstream effectors, EphB1 and Sert, which act sequentially at different steps of the maturation process in the visual pathway.
Transcription (transcription) of Sert
5) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.08 Pain Relevance 0.20
To further test whether Zic2 is required for Sert expression in the VT region of the retina, we examined Sert mRNA levels in Zic2 hypomorphic mutant mice (Zic2kd/kd).
Transcription (levels) of Sert in retina
6) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
We demonstrate here that Zic2 induces directly the transcription of Sert in iRGCs.
Transcription (transcription) of Sert
7) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.65
Consistent with Zic2 expression, Sert mRNA was detected in the VT retina at this age.
Transcription (detected) of Sert in retina
8) Confidence 0.61 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Zic2 directly activates Sert transcription
Transcription (transcription) of Sert
9) Confidence 0.58 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
To determine if Sert is a direct transcriptional target of Zic2, we investigated whether this transcription factor activates Sert regulatory sequences.
Transcription (transcription) of Sert
10) Confidence 0.58 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
SERT mRNA expression and 5-HT neurons analysis
Transcription (expression) of SERT in 5-HT neurons
11) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.24 Pain Relevance 0
Using mRNA hybridization and immunohistology, we also report SERT mRNA expression and a few 5-HT neurons in the vicinity of the RTN/pFRG area.
Transcription (expression) of SERT in 5-HT neurons
12) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.55 Pain Relevance 0.36
First, SERT mRNA expression formed a median, large and heavily stained triangle, possibly delimiting the raphe magnus (Rm in Fig. 3).
Transcription (expression) of SERT associated with raphe magnus
13) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.20 Pain Relevance 0.25
Second, SERT mRNA expression was also found at a more lateral spot, about 500 µm from the midline, just lateral to the pyramidal tract (py), in an area possibly corresponding to the para-pyramidal subgroup of 5-HT neurons (ppy in Fig. 3).
Transcription (expression) of SERT in lateral
14) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.19 Pain Relevance 0.23
To analyze SERT mRNA expression in neonatal mice (n?
Spec (analyze) Transcription (expression) of SERT
15) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.19 Pain Relevance 0
SERT mRNA expression and 5-HT neurons in the RTN/pFRG area
Transcription (expression) of SERT in 5-HT neurons
16) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.47 Pain Relevance 0.22
Regional mRNA hybridization in situ for the SERT sequences (Mus musculus, accession numbers: NM_010484.2) was performed as already described [26] with the following antisens oligonucleotide:
Transcription (hybridization) of SERT
17) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.17 Pain Relevance 0
To validate the primers, dorsonasal (DN) and VT retinal segments were dissected out from E16.5 WT embryos and endogenous levels of Sert mRNA were measured.
Transcription (levels) of Sert in embryos
18) Confidence 0.45 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
Sert mRNA levels were highly reduced in the VT retina of Zic2kd/kd embryos compared with WT littermates (Figure 3A).
Transcription (levels) of Sert in embryos
19) Confidence 0.45 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0
To study the potential capacity of Zic2 to activate Sert transcription, the 130-bp conserved sequence (putative Sert promoter region) was amplified by PCR, cloned into a luciferase reporter plasmid (pGL3-basic), and used for luciferase assays in 293HEK cells.
Transcription (transcription) of Sert
20) Confidence 0.45 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0

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