INT103024

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.02
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Ptgis) extracellular space (Ptgis) endoplasmic reticulum (Ptgis)
Anatomy Link Frequency
lung 4
sensory neuron 2
liver 2
Ptgis (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 18 99.92 Very High Very High Very High
cytokine 12 97.92 Very High Very High Very High
Inflammatory response 4 96.04 Very High Very High Very High
aspirin 72 94.96 High High
ischemia 6 92.44 High High
qutenza 12 82.72 Quite High
chemokine 2 80.52 Quite High
cINOD 4 61.24 Quite High
antagonist 28 55.16 Quite High
Inflammation 12 52.44 Quite High
Disease Link Frequency Relevance Heat
Injury 14 99.92 Very High Very High Very High
Lung Cancer 40 99.20 Very High Very High Very High
Pulmonary Hypertension 300 98.72 Very High Very High Very High
Adhesions 4 98.72 Very High Very High Very High
INFLAMMATION 24 95.68 Very High Very High Very High
Cv Unclassified Under Development 6 92.44 High High
Hypertrophy 72 91.16 High High
Cleidocranial Dysplasia 58 85.08 High High
Nociception 2 84.40 Quite High
Body Weight 26 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intratracheal transfer of the human prostacyclin synthase (PGIS) gene to rats with MCT-induced PAH augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced PAH, and improved survival in MCT rats [56].
Positive_regulation (transfer) of Gene_expression (transfer) of PGIS associated with pulmonary hypertension
1) Confidence 0.48 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.75 Pain Relevance 0.04
Intratracheal transfer of the human prostacyclin synthase (PGIS) gene to rats with MCT-induced PAH augmented pulmonary prostacyclin synthesis, ameliorated MCT-induced PAH, and improved survival in MCT rats [56].
Positive_regulation (transfer) of Gene_expression (transfer) of prostacyclin synthase associated with pulmonary hypertension
2) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2843902 Disease Relevance 0.75 Pain Relevance 0.04
In the sensory neuron-mediated enhancement of endothelial production of prostacyclin, CGRP-induced activation of both endothelial NOS and cyclooxygenase-1 may be critically involved.
Positive_regulation (enhancement) of Gene_expression (production) of prostacyclin in sensory neuron associated with calcitonin gene-related peptide
3) Confidence 0.22 Published 2002 Journal J. Lab. Clin. Med. Section Abstract Doc Link 12024109 Disease Relevance 0.42 Pain Relevance 0.47
Therefore, if the sensory neurons can be activated by the pathologic process of hepatic I/R, they might help ameliorate I/R-induced liver injury by promoting the endothelial production of prostacyclin, also known as prostaglandin I(2).
Positive_regulation (promoting) of Gene_expression (production) of prostacyclin in liver associated with injury
4) Confidence 0.18 Published 2002 Journal J. Lab. Clin. Med. Section Abstract Doc Link 12024109 Disease Relevance 0.62 Pain Relevance 0.51
In 2004, Keith et al. [45] found that increased pulmonary production of prostaglandin I2 (prostacyclin) by lung-specific overexpression of prostacyclin synthase decreases lung tumor incidence and multiplicity in chemically-induced murine lung cancer models.
Positive_regulation (overexpression) of Gene_expression (overexpression) of prostacyclin in lung associated with lung cancer
5) Confidence 0.04 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.74 Pain Relevance 0.32
In 2004, Keith et al. [45] found that increased pulmonary production of prostaglandin I2 (prostacyclin) by lung-specific overexpression of prostacyclin synthase decreases lung tumor incidence and multiplicity in chemically-induced murine lung cancer models.
Positive_regulation (increased) of Gene_expression (production) of prostacyclin in lung associated with lung cancer
6) Confidence 0.03 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1899177 Disease Relevance 0.74 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox