INT103037

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.76
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Anatomy Link Frequency
microglia 2
hypothalamus 1
spinal cord 1
peripheral nerve 1
Bdkrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 389 100.00 Very High Very High Very High
b2 receptor 5 100.00 Very High Very High Very High
allodynia 118 99.80 Very High Very High Very High
Inflammatory marker 6 99.64 Very High Very High Very High
Thermal hyperalgesia 27 99.58 Very High Very High Very High
spinal dorsal horn 37 98.32 Very High Very High Very High
Peripheral nerve injury 5 98.04 Very High Very High Very High
antagonist 76 96.80 Very High Very High Very High
Spinal cord 103 96.72 Very High Very High Very High
bradykinin 92 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 231 99.80 Very High Very High Very High
INFLAMMATION 44 99.64 Very High Very High Very High
Hyperalgesia 68 99.58 Very High Very High Very High
Hypertension 18 98.48 Very High Very High Very High
Stress 45 98.44 Very High Very High Very High
Congenital Anomalies 9 97.72 Very High Very High Very High
Nervous System Injury 14 97.60 Very High Very High Very High
Pressure And Volume Under Development 24 97.00 Very High Very High Very High
Insulin Resistance 20 95.40 Very High Very High Very High
Diabetes Mellitus 217 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of microglia inhibitors on mRNA levels of B1R, TRPV1, IL-1?
Transcription (levels) of B1R in microglia associated with b1 receptor
1) Confidence 0.70 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.61 Pain Relevance 0.68
The enhanced mRNA expression (B1R, IL-1beta, TNF-alpha, TRPV1) and Iba-1 immunoreactivity in the STZ spinal cord were normalized by fluorocitrate or minocycline, yet B1R binding sites were reduced by 38%.
Transcription (expression) of B1R in spinal cord
2) Confidence 0.69 Published 2010 Journal J Neuroinflammation Section Body Doc Link 20587056 Disease Relevance 0.16 Pain Relevance 0
Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system after peripheral nerve injury.
Transcription (expression) of Kinin B1 in peripheral nerve associated with nervous system injury, b2 receptor and peripheral nerve injury
3) Confidence 0.68 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.25 Pain Relevance 0.40
To further substantiate the contribution of B1R in the production of O2•?
Transcription (contribution) of B1R associated with b1 receptor
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.53
However, the increased mRNA level of TRPV1 in STZ was much less striking (3-fold) than that of B1R (27-fold), IL-1?
Transcription (level) of B1R associated with b1 receptor
5) Confidence 0.67 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2913947 Disease Relevance 0.47 Pain Relevance 0.89
This study aims at defining the contribution of kinin B(1) receptor (B(1)R) and the oxidative stress on sensory abnormalities and arterial hypertension in a rat model of insulin resistance.
Transcription (contribution) of kinin B associated with stress, pressure and volume under development, congenital anomalies and insulin resistance
6) Confidence 0.67 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.17 Pain Relevance 0.29
Sprague-Dawley rats were made diabetic with STZ (65 mg/kg, i.p.), and 4 days later, two specific inhibitors of microglial cells (fluorocitrate, 1 nmol, i.t.; minocycline, 10 mg/kg, i.p.) were administered to assess the impact on thermal hyperalgesia, allodynia and mRNA expression (qRT-PCR) of B1R and pro-inflammatory markers.
Transcription (expression) of B1R in microglial cells associated with allodynia, diabetes mellitus, inflammatory marker, b1 receptor and thermal hyperalgesia
7) Confidence 0.52 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2913947 Disease Relevance 1.30 Pain Relevance 1.23
Kinin B1 and B2 receptor mRNA expression in the hypothalamus of spontaneously hypertensive rats.
Transcription (expression) of Kinin B1 in hypothalamus associated with hypertension and b2 receptor
8) Confidence 0.46 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 12025958 Disease Relevance 0.80 Pain Relevance 0.32

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