INT103039

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 2
SPANXB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 96 100.00 Very High Very High Very High
antagonist 11 99.98 Very High Very High Very High
dexamethasone 11 99.98 Very High Very High Very High
b2 receptor 29 99.80 Very High Very High Very High
B1 receptor 12 99.74 Very High Very High Very High
Inflammation 27 99.44 Very High Very High Very High
Analgesic 1 95.88 Very High Very High Very High
cINOD 1 95.32 Very High Very High Very High
bradykinin 42 56.00 Quite High
agonist 11 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 5 100.00 Very High Very High Very High
INFLAMMATION 28 99.44 Very High Very High Very High
Asthma 15 87.96 High High
Nicotine Addiction 12 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 1 5.00 Very Low Very Low Very Low
Cough 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings are consistent with other evidence that peptide B1 receptor antagonists inhibit spinal nociceptive reflexes only after induction of B1 receptors by inflammation and support the potential therapeutic utility of B1 receptor antagonists as analgesic and anti-inflammatory drugs.
Negative_regulation (inhibit) of Positive_regulation (induction) of B1 in spinal associated with nociception, inflammation, analgesic, antagonist, b1 receptor and cinod
1) Confidence 0.06 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025959 Disease Relevance 0.83 Pain Relevance 0.78
In line with this, the present data demonstrates that dexamethasone inhibited nicotine-enhanced kinin B1 and B2 receptor-mediated effects in murine airways.
Negative_regulation (inhibited) of Positive_regulation (enhanced) of B1 associated with nicotine, b2 receptor and dexamethasone
2) Confidence 0.03 Published 2010 Journal Respir Res Section Body Doc Link PMC2845563 Disease Relevance 0.25 Pain Relevance 0.53

General Comments

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