INT10304

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Context Info
Confidence 0.48
First Reported 1986
Last Reported 2010
Negated 4
Speculated 3
Reported most in Abstract
Documents 89
Total Number 92
Disease Relevance 9.28
Pain Relevance 49.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRK1) signal transducer activity (OPRK1)
Anatomy Link Frequency
brain 6
alveolar macrophages 2
insular cortex 1
gut 1
dorsal horn 1
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 184 100.00 Very High Very High Very High
Opioid 149 100.00 Very High Very High Very High
Dynorphin 122 100.00 Very High Very High Very High
opioid receptor 104 100.00 Very High Very High Very High
agonist 97 100.00 Very High Very High Very High
opiate 36 100.00 Very High Very High Very High
MU agonist 24 100.00 Very High Very High Very High
mu opioid receptor 12 100.00 Very High Very High Very High
Buprenorphine 4 100.00 Very High Very High Very High
antinociception 3 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Drug Dependence 6 99.62 Very High Very High Very High
Neuroblastoma 3 99.32 Very High Very High Very High
Opiate Addiction 13 99.20 Very High Very High Very High
Cancer 10 99.08 Very High Very High Very High
Glioblastoma 1 99.04 Very High Very High Very High
Disease 27 99.00 Very High Very High Very High
Adenocarcinoma 1 98.64 Very High Very High Very High
Nociception 3 98.28 Very High Very High Very High
Glioma 5 98.24 Very High Very High Very High
Metastasis 1 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Characterization of kappa1-opioid receptor binding in human insular cortex.
kappa1-opioid Binding (binding) of in insular cortex associated with opioid receptor
1) Confidence 0.48 Published 1999 Journal Life Sci. Section Title Doc Link 10465345 Disease Relevance 0.17 Pain Relevance 0.52
These chimeras may be useful in identifying novel kappa receptor agonists that bind to the second extracellular loop of the receptor and share the desirable therapeutic profile of dynorphin A.
kappa receptor Binding (bind) of associated with dynorphin and agonist
2) Confidence 0.47 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15857313 Disease Relevance 0.05 Pain Relevance 0.72
In contrast, dynorphin A analogs bound to the chimeras with affinities similar to those with which they bound to the kappa opioid receptor.
kappa opioid receptor Binding (bound) of associated with dynorphin and kappa opioid receptor
3) Confidence 0.47 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15857313 Disease Relevance 0.12 Pain Relevance 1.06
Selective changes in mu, delta and kappa opioid receptor binding in certain limbic regions of the brain in Alzheimer's disease patients.
kappa opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and disease
4) Confidence 0.47 Published 1987 Journal Brain Res. Section Title Doc Link 3032356 Disease Relevance 0.49 Pain Relevance 0.35
Limbic regions of the brain of Alzheimer's disease patients show selective changes in mu, delta and kappa opioid receptor binding.
kappa opioid receptor Binding (binding) of in brain associated with kappa opioid receptor and disease
5) Confidence 0.47 Published 1986 Journal NIDA Res. Monogr. Section Title Doc Link 2829002 Disease Relevance 0.46 Pain Relevance 0.33
Six of these kappa-opioid receptor agonists decreased dose-dependently the total number of responses and with an order of potency consistent with kappa-opioid receptor interaction.
kappa-opioid receptor Binding (interaction) of associated with agonist, kappa opioid receptor and potency
6) Confidence 0.47 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10448921 Disease Relevance 0 Pain Relevance 0.50
METHODS: Specimens obtained at craniotomy from 30 patients with glioma and nonneoplastic brain disorders were evaluated for their kappa-opioid receptor binding.
kappa-opioid receptor Binding (binding) of in brain
7) Confidence 0.46 Published 1998 Journal Cancer Section Body Doc Link 9874464 Disease Relevance 0.09 Pain Relevance 0
Kappa-opioid receptor binding varies inversely with tumor grade in human gliomas.
Kappa-opioid receptor Binding (binding) of associated with cancer, kappa opioid receptor and glioma
8) Confidence 0.46 Published 1998 Journal Cancer Section Title Doc Link 9874464 Disease Relevance 0.39 Pain Relevance 0.33
Unlike other opioids, such as oxycodone, oxymorphone does not bind to the kappa-opioid receptor.
kappa-opioid receptor Neg (not) Binding (bind) of
9) Confidence 0.44 Published 2007 Journal Ann Pharmacother Section Body Doc Link 17595308 Disease Relevance 0.07 Pain Relevance 0
Interaction of kappa-receptor is suggested.
kappa-receptor Binding (Interaction) of
10) Confidence 0.43 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10825321 Disease Relevance 0.87 Pain Relevance 0.40
Kappa receptor specific binding was defined as the (-)-[3H]ethylketocyclazocine bound in the presence of 100 nM D-ala2-D-leu5-enkephalin and 30 nM morphine.
Kappa receptor Binding (binding) of associated with enkephalin and morphine
11) Confidence 0.42 Published 1987 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2892925 Disease Relevance 0 Pain Relevance 0.27
The most impressive result obtained from the binding studies lies in the fact that this series of 2-[2-(acylamino)ethyl]-1,4-benzodiazepine derivatives binds the human cloned kappa-opioid receptor subtype very tightly.
cloned kappa-opioid receptor Binding (binds) of associated with kappa opioid receptor
12) Confidence 0.42 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12930147 Disease Relevance 0 Pain Relevance 0.26
Furthermore, the results obtained are discussed with respect to the interaction with the homology model of the human kappa-opioid receptor, built on the recently solved crystal structure of rhodopsin.
kappa-opioid receptor Binding (interaction) of associated with kappa opioid receptor
13) Confidence 0.42 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12930147 Disease Relevance 0 Pain Relevance 0.28
The results show that kappa-opioid selective agonists and antagonists inhibit binding of this ligand in human brain with comparable affinities and rank order as previously described for rat and guinea pig brain and the cloned kappa1-opioid receptor subtype.
kappa1-opioid Binding (binding) of in brain associated with antagonist, agonist, opioid receptor and opioid
14) Confidence 0.37 Published 1999 Journal Life Sci. Section Abstract Doc Link 10465345 Disease Relevance 0.15 Pain Relevance 0.55
Chemical and pharmacological studies on compounds 6 have been pursued with the aim of expanding the SAR data and validating the previously proposed model of interaction of this class of compounds with the kappa-opioid receptor.
kappa-opioid receptor Binding (interaction) of associated with kappa opioid receptor
15) Confidence 0.37 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12930147 Disease Relevance 0 Pain Relevance 0.16
The four stereoisomers of the two peripherally selective kappa-opioid agonists EMD 60,400 and EMD 61,753 were synthesized, tested for stereoisomeric purity, and examined for affinity to the kappa opioid receptor.
kappa opioid receptor Spec (examined) Binding (affinity) of associated with mu agonist and kappa opioid receptor
16) Confidence 0.36 Published 1994 Journal Chirality Section Abstract Doc Link 7857777 Disease Relevance 0 Pain Relevance 0.26
A structurally unique kappa antagonist (JDTic) provides an additional tool to characterize kappa opioid receptor.
kappa opioid receptor Binding (characterize) of associated with antagonist and kappa opioid receptor
17) Confidence 0.36 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17305578 Disease Relevance 0 Pain Relevance 0.41
Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.
kappa opioid receptor Binding (affinity) of associated with dynorphin and kappa opioid receptor
18) Confidence 0.36 Published 2008 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 18487043 Disease Relevance 0 Pain Relevance 0.38
Opioid agonists produce analgesia in humans and other mammals by binding to three distinct types of G protein-coupled receptors; mu (MOR), delta (DOR), and kappa (KOR) opioid receptors.
KOR Binding (binding) of associated with mu agonist, opioid receptor and analgesia
19) Confidence 0.36 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17452077 Disease Relevance 0 Pain Relevance 0.90
Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction.
OPRK1 Binding (association) of associated with addiction, kappa opioid receptor and opiate
20) Confidence 0.36 Published 2004 Journal Pharmacogenetics Section Title Doc Link 15608558 Disease Relevance 0.32 Pain Relevance 0.78

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