INT103048

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Context Info
Confidence 0.16
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 2.73
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pmp2) transport (Pmp2) cellular_component (Pmp2)
biological_process (Pmp2) cytoplasm (Pmp2)
Anatomy Link Frequency
brain 2
bands 1
cortex 1
body 1
Pmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 5 97.64 Very High Very High Very High
Anterior cingulate cortex 6 96.52 Very High Very High Very High
alcohol 18 91.52 High High
qutenza 2 90.24 High High
Eae 36 87.44 High High
Pain 10 86.00 High High
tolerance 12 78.60 Quite High
Thalamus 18 77.44 Quite High
agonist 1 76.48 Quite High
amygdala 26 63.32 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 7 99.32 Very High Very High Very High
Body Weight 78 98.60 Very High Very High Very High
Ganglion Cysts 8 97.64 Very High Very High Very High
Post-traumatic Stress Disorder 42 96.76 Very High Very High Very High
Apoptosis 38 96.52 Very High Very High Very High
Cognitive Disorder 56 94.84 High High
Pain 8 84.36 Quite High
Nutritional Deficiencies 6 79.60 Quite High
Weight Gain 12 73.64 Quite High
Infection 66 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the groups of mice that were subjected to single exposures of PCP on either P2 or P7 had significantly decreased body weights for similar periods of time but showed little or no disturbances in learning and memory performance in the above-mentioned behavioral tests.
Gene_expression (exposures) of P2 in body associated with cognitive disorder and body weight
1) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.71 Pain Relevance 0.04
Rather the increased staining in the P2+P7 animals indicates that PCP exposure at P2 has produced alterations in the brain that result in it being more susceptible to the apoptotic effects of PCP at P7.
Gene_expression (exposure) of P2 in brain associated with apoptosis
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.26 Pain Relevance 0.15
To quantify differences in neuroapoptosis between P7 and P2+P7 treatments, three coronal sections were selected from each animal, one including the caudate and anterior cingulate cortex (P6 #18, 3.51 mm), laterodorsal thalamic nuclei (P6 # 27, 4.59 mm) and retrosplenial cortex (P6 #33, 5.31 mm), [13].
Gene_expression (treatments) of P2 in cortex associated with anterior cingulate cortex
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.06 Pain Relevance 0.09
In the present study we have demonstrated that robust spatial learning and memory deficits occur in mice that were subjected to two PCP exposures (i.e., on P2+P7) but not as a result of a single exposure on P2 or P7, and that these impairments are likely to be permanent in nature and encompass non-spatial forms of learning as well.
Gene_expression (exposures) of P2
4) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.08 Pain Relevance 0.07
In summary, small differences may have existed between P2+P7 PCP-treated and control mice during the cued trials resulting in transient performance deficits suggesting that mild non-associative disturbances in the PCP-treated mice (e.g., visual or sensorimotor disturbances, altered motivation) may have briefly affected performance although the two groups eventually performed at approximately equal levels.
Gene_expression (existed) of P2
5) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0
In the P2+P7 group all of these regions were involved except for the mammillary bodies.
Gene_expression (group) of P2
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.14 Pain Relevance 0.05
Flowcytometery and real time one step RT-PCR documented that P-2 shRNA expressed either from Pol III (pH1-P2) or Pol II promoter (pCMV-P2) was as efficient as P-2 siRNA, when the validation was done with pAcGFP1N1-CHPV-P.
Gene_expression (expressed) of P-2 shRNA
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.13 Pain Relevance 0.04
Flowcytometery and real time one step RT-PCR documented that P-2 shRNA expressed either from Pol III (pH1-P2) or Pol II promoter (pCMV-P2) was as efficient as P-2 siRNA, when the validation was done with pAcGFP1N1-CHPV-P.
Gene_expression (siRNA) of P-2
8) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.13 Pain Relevance 0.04
The change in P2X3 protein was selective because P2X2 protein was expressed equally in both strains.
Gene_expression (expressed) of P2X2 protein associated with sprains and strains
9) Confidence 0.03 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12028354 Disease Relevance 1.13 Pain Relevance 0.70
We next focused on the general pattern of CD81, EBP50 and Sap97, at two time points, P2 (Figure 6) and P20 (Figure 5).
Gene_expression (pattern) of P2
10) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2610370 Disease Relevance 0.09 Pain Relevance 0
On immunoblots of rat brain fractions, the 5557 phosphomotif antibody detected a weak set of bands in S1 (postnuclear supernatant), S2 (cytosol plus light membranes fraction), and P2 (synaptosome-enriched fraction) (Fig. 2, top panel).
Gene_expression (detected) of P2 in bands
11) Confidence 0.02 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0
-catenin was also enriched in the P2 and PSD1 fractions of rat brain (Fig. 6C).
Gene_expression (enriched) of P2 in brain
12) Confidence 0.01 Published 2009 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2667352 Disease Relevance 0 Pain Relevance 0

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