INT103049

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Context Info
Confidence 0.60
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.00
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
neurons 2
colon 1
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 243 100.00 Very High Very High Very High
dorsal root ganglion 83 99.44 Very High Very High Very High
nav1.8 3 94.88 High High
qutenza 18 92.04 High High
Neurotransmitter 13 91.36 High High
depression 14 90.56 High High
Inflammation 8 90.00 High High
Brush evoked pain 63 86.56 High High
Eae 78 79.04 Quite High
nociceptor 19 78.84 Quite High
Disease Link Frequency Relevance Heat
Pain 259 100.00 Very High Very High Very High
Sprains And Strains 391 99.48 Very High Very High Very High
Ganglion Cysts 114 99.44 Very High Very High Very High
Nociception 21 99.00 Very High Very High Very High
Targeted Disruption 103 98.56 Very High Very High Very High
Depression 14 90.56 High High
Nervous System Injury 57 90.28 High High
INFLAMMATION 8 90.00 High High
Neuropathic Pain 186 86.56 High High
Stress 6 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The change in P2X3 protein was selective because P2X2 protein was expressed equally in both strains.
Regulation (change) of P2X3 protein associated with sprains and strains
1) Confidence 0.60 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12028354 Disease Relevance 1.20 Pain Relevance 0.71
The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood.
Regulation (modulated) of P2X3 associated with pain
2) Confidence 0.60 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16627751 Disease Relevance 0.10 Pain Relevance 0.16
The regulation of P2rx3 did not correlate significantly across strains with any of the pain phenotypes considered.
Regulation (regulation) of P2rx3 associated with pain and sprains and strains
3) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.35 Pain Relevance 0.47
Thus, our data are consistent with the notion that the phosphorylation state of serine residues is dominant to regulate P2X3 receptor activity.
Regulation (regulate) of P2X3
4) Confidence 0.56 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.22 Pain Relevance 0.17
It is also possible that the contributions of P2X2 and P2X3 subunits to neurotransmission in the colon might only be revealed under pathophysiological conditions.
Regulation (contributions) of P2X3 in colon
5) Confidence 0.36 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.56 Pain Relevance 0.04
The present study was designed to assess the functional role of P2X2 and P2X3 receptor subunits on colonic motility in vitro and in vivo.
Regulation (role) of P2X3
6) Confidence 0.36 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2858605 Disease Relevance 0.33 Pain Relevance 0
Axotomy induced marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 in all 5 strains with lesser and variable change observed for P2rx3 and Trpv1 (Fig. 1).
Regulation (change) of P2rx3 associated with sprains and strains
7) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.12 Pain Relevance 0.58
That is, all of the methods showed marked down-regulation of Scn10a, Scn11a, Trpa1 and Trpm8 with lesser and variable change in P2rx3 and Trpv1.
Regulation (change) of P2rx3
8) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 0.55 Pain Relevance 0.27
Potentiation of P2X3 receptor responses of WT trigeminal neurons observed after application of calcineurin blockers was not accompanied by a change in receptor serine phosphorylation, that remained at its constitutive level.
Regulation (responses) of P2X3 in neurons
9) Confidence 0.25 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.25 Pain Relevance 0.21
Indeed, after forced Runx1 expression, we observed a selective up-regulation of RET, IB4-binding, and P2X3 in differentiated bTUB+ neurons, as well as a decrease of RT97 and CGRP expression in the transplants.
Regulation (regulation) of P2X3 in neurons
10) Confidence 0.19 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.31 Pain Relevance 0.31

General Comments

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