INT103061

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.67
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
nerve 2
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 216 100.00 Very High Very High Very High
opioid receptor 1 99.98 Very High Very High Very High
qutenza 10 98.28 Very High Very High Very High
Opioid 2 96.80 Very High Very High Very High
fluoxetine 47 94.60 High High
Desipramine 49 94.00 High High
cytokine 19 93.68 High High
Inflammation 50 90.32 High High
antidepressant 45 90.24 High High
Inflammatory mediators 2 77.76 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 56 99.96 Very High Very High Very High
Bronchial Hyperreactivity 2 93.08 High High
INFLAMMATION 59 90.32 High High
Aids-related Complex 2 88.76 High High
Disease 7 86.16 High High
Injury 28 81.68 Quite High
Pneumonia 3 80.76 Quite High
Necrosis 6 76.56 Quite High
Cancer 6 76.20 Quite High
Adult Respiratory Distress Syndrome 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that after nerve injury, RANTES expression was strongly upregulated in DRG neurons ipsilateral and contralateral to the nerve injury, when compared to sham control tissue.
Positive_regulation (upregulated) of Gene_expression (expression) of RANTES in nerve associated with nervous system injury
1) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.79 Pain Relevance 0.06
For all experiments, MCP-1, SDF1, RANTES and IP10 were added to the cells in random order, after which capsaicin, high K+ (50 K) and ATP were added.
Positive_regulation (experiments) of Gene_expression (added) of RANTES associated with qutenza
2) Confidence 0.29 Published 2007 Journal Mol Pain Section Body Doc Link PMC2228278 Disease Relevance 0.09 Pain Relevance 0.27
Expression of various chemokine mRNAs (MCP-3, MIP-1alpha, RANTES, and eotaxin) increased in rats treated with PT1 or PT2 on day 1 and/or day 3.
Positive_regulation (increased) of Gene_expression (Expression) of RANTES associated with chemokine
3) Confidence 0.24 Published 2002 Journal Inhal Toxicol Section Abstract Doc Link 12028805 Disease Relevance 0.23 Pain Relevance 0.09
Previously, our laboratory reported that activation of the mu-opioid receptor induced the expression of CCL2, CCL5, and CXCL10, as well as CCR5 and CXCR4.
Positive_regulation (induced) of Gene_expression (expression) of CCL5 associated with opioid receptor
4) Confidence 0.18 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.62
-induced RANTES expression as well as the activity of nuclear factor-?
Positive_regulation (induced) of Gene_expression (expression) of RANTES
5) Confidence 0.10 Published 2007 Journal Respir Res Section Abstract Doc Link PMC1876225 Disease Relevance 0.57 Pain Relevance 0.86

General Comments

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