INT103073

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.74
Pain Relevance 4.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) aging (Ccl2) extracellular region (Ccl2)
cytoskeleton organization (Ccl2) cytoplasm (Ccl2)
Anatomy Link Frequency
neurons 4
DRG 4
neuronal 2
peripheral nerve 2
Ccl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 49 100.00 Very High Very High Very High
Peripheral nerve injury 5 99.98 Very High Very High Very High
chemokine 61 99.12 Very High Very High Very High
Inflammatory marker 69 98.68 Very High Very High Very High
Neuropathic pain 41 98.44 Very High Very High Very High
Eae 35 96.80 Very High Very High Very High
Spinal cord 49 95.28 Very High Very High Very High
allodynia 9 94.88 High High
cytokine 13 94.08 High High
intrathecal 9 93.28 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 50 100.00 Very High Very High Very High
Nervous System Injury 18 99.98 Very High Very High Very High
Diabetes Mellitus 72 99.84 Very High Very High Very High
Infection 5 99.36 Very High Very High Very High
Myocardial Infarction 24 98.92 Very High Very High Very High
Neuropathic Pain 75 98.44 Very High Very High Very High
INFLAMMATION 122 98.36 Very High Very High Very High
Injury 67 96.80 Very High Very High Very High
Rheumatoid Arthritis 10 94.72 High High
Demyelinating Disease 6 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry showed that MCP-1 mRNA expression was markedly upregulated in the ipsilateral DRG with weaker increase in the contralateral one at 24 h after the ligation, indicating that the elevation in MCP-1ir detected by immunohistochemistry was due to an upregulation of MCP-1 production by the DRG neurons themselves.
Positive_regulation (due) of Positive_regulation (elevation) of MCP-1ir in neurons
1) Confidence 0.50 Published 2004 Journal Neurosci. Res. Section Abstract Doc Link 15041200 Disease Relevance 0.42 Pain Relevance 0.67
Despite increased MCP-1 in small and large DRG neurons, a remarkable increase in MCP-1-IR terminals was observed in the spinal superficial laminae following CCI and L5SNL, but not following axotomy; however, in the deeper laminae, a considerable increase in MCP-1-IR terminals, which may originate from the large and injured L5 DRG neurons, was found after L5 SNL.
Positive_regulation (increase) of Positive_regulation (increased) of MCP-1 in DRG associated with dorsal root ganglion and eae
2) Confidence 0.50 Published 2009 Journal Brain Res. Section Abstract Doc Link 19059387 Disease Relevance 1.45 Pain Relevance 1.14
In contrast, in DRG, only Scya2 (chemokine C-C motif ligand 2) mRNA was up-regulated, leading to an increase in its gene product monocyte chemoattractant protein-1.
Positive_regulation (leading) of Positive_regulation (increase) of chemoattractant protein-1 in DRG associated with chemokine
3) Confidence 0.44 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17883394 Disease Relevance 0.72 Pain Relevance 0.63
MCP-1 levels have been reported to be elevated in patients with an acute myocardial infarction [22] and poor glycemic control has been suggested to induce high levels of MCP-1 in diabetic patients [23].
Positive_regulation (induce) of Positive_regulation (induce) of MCP-1 associated with diabetes mellitus and myocardial infarction
4) Confidence 0.38 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.46 Pain Relevance 0.09
Elevated levels of CRP (p = 0.031) and MCP-1 (p = 0.016) measured in-hospital were found in patients classified with abnormal glucose regulation at three-month follow-up (Table 3).
Positive_regulation (levels) of Positive_regulation (Elevated) of MCP-1
5) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.49 Pain Relevance 0.25
Elevated levels of CRP (p = 0.031) and MCP-1 (p = 0.016) measured in-hospital were found in patients classified with abnormal glucose regulation at three-month follow-up (Table 3).
Positive_regulation (Elevated) of Positive_regulation (levels) of MCP-1
6) Confidence 0.35 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.49 Pain Relevance 0.25
Despite this observation, our results could indicate either the presence of CCR2 on both cell types or that CCL2-evoked neuronal activation is indirectly mediated following glial CCR2 excitation and release of a gliotransmitter onto neurons.
Positive_regulation (mediated) of Positive_regulation (activation) of CCL2-evoked in neuronal
7) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009975 Disease Relevance 0.33 Pain Relevance 0.41
Cumulatively these data suggest that processes involved in peripheral nerve regeneration do not contribute to the maintenance of MCP-1 upregulation.
Positive_regulation (maintenance) of Positive_regulation (upregulation) of MCP-1 in peripheral nerve
8) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC3019206 Disease Relevance 0.73 Pain Relevance 0.41
Messages for IL-6, iNOS and MCP-1 were significantly increased as a result of infection.
Positive_regulation (increased) of Positive_regulation (increased) of MCP-1 associated with infection
9) Confidence 0.23 Published 2002 Journal Acta Otolaryngol. Section Abstract Doc Link 12030571 Disease Relevance 0.47 Pain Relevance 0.32
This is because along with a previous study, where the importance of CXCR4/SDF1 signaling in a NRTI-associated neuropathic pain model was demonstrated, other studies had shown that peripheral nerve injury resulted in the upregulation of CCR2 and its ligand MCP1 in DRG neurons [7,22,24,36-38].
Positive_regulation (resulted) of Positive_regulation (upregulation) of MCP1 in neurons associated with dorsal root ganglion, nervous system injury, neuropathic pain and peripheral nerve injury
10) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.18 Pain Relevance 0.54

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