INT103094

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2011
Negated 4
Speculated 5
Reported most in Body
Documents 308
Total Number 313
Disease Relevance 177.26
Pain Relevance 34.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
colon 5
macrophages 3
lung 3
fat 2
skin 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4624 100.00 Very High Very High Very High
COX-2 inhibitor 108 100.00 Very High Very High Very High
cINOD 697 99.96 Very High Very High Very High
antagonist 632 99.84 Very High Very High Very High
Osteoarthritis 280 99.60 Very High Very High Very High
Inflammation 3425 99.48 Very High Very High Very High
Adalimumab 292 99.32 Very High Very High Very High
ischemia 228 99.32 Very High Very High Very High
cytokine 529 98.36 Very High Very High Very High
Angina 52 97.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 9467 100.00 Very High Very High Very High
Obesity 3340 100.00 Very High Very High Very High
Colon Cancer 1873 100.00 Very High Very High Very High
Repression 253 100.00 Very High Very High Very High
Apoptosis 4957 99.98 Very High Very High Very High
Pressure And Volume Under Development 425 99.96 Very High Very High Very High
Disease 1897 99.88 Very High Very High Very High
Targeted Disruption 399 99.84 Very High Very High Very High
Liposarcoma 371 99.84 Very High Very High Very High
Reperfusion Injury 27 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
binding to PPAR.
PPAR Binding (binding) of
1) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2464819 Disease Relevance 0.58 Pain Relevance 0.14
In the presence of ligand, PPARs bind to their cognate regulatory
PPAR Binding (bind) of
2) Confidence 0.47 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.99 Pain Relevance 0.03
PPAR interacts
PPAR Binding (interacts) of
3) Confidence 0.46 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0 Pain Relevance 0.03
clofibrate, which also bind to PPAR?
PPAR Binding (bind) of
4) Confidence 0.46 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.84 Pain Relevance 0.59
natural ligand for PPAR?
PPAR Binding (ligand) of
5) Confidence 0.46 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 0.38 Pain Relevance 0.34
membranes suggests that they could activate PPAR, induce PPAR binding to PPRE,
PPAR Binding (binding) of
6) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0
was reported to interact with PPAR-?
PPAR Binding (interact) of
7) Confidence 0.42 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.70 Pain Relevance 0
in samples from inflamed human airways has demonstrated that the immunoreactivity for PPAR?
PPAR Binding (immunoreactivity) of
8) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.12 Pain Relevance 0.09
bound the wild-type PPARA ?
PPARA Binding (bound) of
9) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0
expression level inversely correlates with post-ischemic cardiac function [12] and extends the previous report of an association between PPARA ?
PPARA Binding (association) of
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.89 Pain Relevance 0.16
PPAR ligands: identification, interaction with PPARs and specificity
PPAR Binding (interaction) of
11) Confidence 0.41 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.24 Pain Relevance 0.04
On the other hand, PPAR ligands exert the antineuroinflammatory activity through preventing upregulation of inflammatory mediators in animal models for neurodegenerative disease and autoimmune disease.
PPAR Binding (ligands) of associated with inflammatory mediators, autoimmune disease and neurodegenerative disease
12) Confidence 0.37 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607969 Disease Relevance 0.92 Pain Relevance 0.49
Direct complex formation between PPAR?
PPAR Binding (formation) of
13) Confidence 0.37 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.35 Pain Relevance 0
In previous work, we reported the involvement of PPAR?
PPAR Binding (involvement) of
14) Confidence 0.37 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 1.12 Pain Relevance 0.04
ligand for PPAR?
PPAR Binding (ligand) of
15) Confidence 0.37 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.72 Pain Relevance 0
PPAR forms a heterodimeric complex with RXR and then recruits coactivator proteins.
PPAR Binding (recruits) of
16) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 0 Pain Relevance 0
Among malignant neuroepithelial tumors, with regard to PPAR ligands, the most extensively studied were tumors of astrocytic origin and neuroblastoma.
PPAR Binding (ligands) of associated with neuroblastoma, malignant neoplastic disease, cancer and neuroepithelial neoplasms
17) Confidence 0.36 Published 2010 Journal PPAR Research Section Abstract Doc Link PMC2841252 Disease Relevance 1.09 Pain Relevance 0.05
PPAR forms a heterodimeric complex with RXR and then recruits coactivator proteins.
PPAR Binding (complex) of
18) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2841252 Disease Relevance 0 Pain Relevance 0
Natural ligands of PPAR?
PPAR Binding (ligands) of
19) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.17 Pain Relevance 0.04
Recent studies indicate that at least in terms of lipid metabolism, the function and specific target genes of PPAR?
PPAR Binding (indicate) of
20) Confidence 0.36 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.17 Pain Relevance 0.12

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