INT103095

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Context Info
Confidence 0.28
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.17
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (ISYNA1) cytoplasm (ISYNA1)
Anatomy Link Frequency
neuronal 2
ISYNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 317 100.00 Very High Very High Very High
Inflammation 309 100.00 Very High Very High Very High
agonist 8 98.84 Very High Very High Very High
nMDA receptor 60 98.54 Very High Very High Very High
COX2 1 97.60 Very High Very High Very High
cINOD 3 97.32 Very High Very High Very High
corticosteroid 4 95.32 Very High Very High Very High
gABA 56 87.92 High High
Glutamate 78 87.52 High High
Hippocampus 54 84.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 349 100.00 Very High Very High Very High
Malignant Neoplastic Disease 2 99.78 Very High Very High Very High
Infection 93 99.54 Very High Very High Very High
Death 38 99.44 Very High Very High Very High
Neurodegenerative Disease 18 99.40 Very High Very High Very High
Disease 228 99.38 Very High Very High Very High
Stress 172 99.12 Very High Very High Very High
Critical Illness 17 98.92 Very High Very High Very High
Malaria 420 98.46 Very High Very High Very High
Injury 80 97.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infection of adherent PBMLs and treatment with an iNOS inhibitor
iNOS Binding (treatment) of associated with infection
1) Confidence 0.28 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.44 Pain Relevance 0
CronbachÂ’s alpha for the total and domain scores of the C-HIPS including the C-HINAS were found to be high, with all coefficients above 0.8.
HIPS Binding (found) of
2) Confidence 0.10 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654792 Disease Relevance 0.06 Pain Relevance 0
The decrease in NMDA receptor density following TDS stress (Harvey et al 2004) further underlines the involvement of iNOS and not nNOS, since iNOS activation is not regulated by neuronal receptors (McCaslin and Oh 1995).


iNOS Binding (involvement) of in neuronal associated with stress and nmda receptor
3) Confidence 0.07 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.92 Pain Relevance 0.24
With repeated trauma, NO originally produced as a neuroprotectant from constitutive NOS now takes on its malignant alter ego courtesy of iNOS.
iNOS Binding (courtesy) of associated with malignant neoplastic disease and injury
4) Confidence 0.07 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.68 Pain Relevance 0.43
iNOS and COX-2 expression even though the DNA binding
iNOS Binding (binding) of
5) Confidence 0.06 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1874678 Disease Relevance 0.07 Pain Relevance 0
To our knowledge, the interaction of INO and dobutamine on the pulmonary circulation has not been previously reported.
INO Binding (interaction) of
6) Confidence 0.06 Published 2001 Journal Crit Care Section Body Doc Link PMC96124 Disease Relevance 0.15 Pain Relevance 0
Effects of peroxisome proliferator-activated receptor agonists on LPS-induced neuronal death in mixed cortical neurons: associated with iNOS and COX-2.
iNOS Binding (associated) of in neuronal associated with agonist, cox2 and death
7) Confidence 0.04 Published 2002 Journal Brain Res. Section Title Doc Link 12031542 Disease Relevance 0.45 Pain Relevance 0.54
It is now accepted that falciparum malaria, historically the major fatal endemic disease in much of this continent, is associated with polymorphisms of these pro-inflammatory cytokines and iNOS, which are induced in this disease.
iNOS Binding (associated) of associated with malaria, inflammation, disease and cytokine
8) Confidence 0.04 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.52 Pain Relevance 0.32
Since the failure of treatment with corticosteroids to ameliorate severe cerebral malaria has been used as evidence against cytokine involvement [4], it warrants recalling that MIF, known to be high in this circumstance [71], antagonizes glucocorticoids [72], and nitric oxide (noting iNOS is also high [71]) inhibits glucocorticoid binding to its receptor [73].
iNOS Binding (binding) of associated with corticosteroid, cerebral malaria and cytokine
9) Confidence 0.04 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.33 Pain Relevance 0.40
INO has been successfully used and associated with improved outcomes in critically ill postoperative patients, who developed severe pulmonary hypertension or RV failure (Della Rocca and Coccia 2005; George et al 2006).
INO Binding (associated) of associated with pulmonary hypertension and critical illness
10) Confidence 0.02 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605326 Disease Relevance 0.53 Pain Relevance 0.11

General Comments

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