INT103096

Context Info Confidence 0.60 First Reported 2002 Last Reported 2011 Negated 5 Speculated 5 Reported most in Body Documents 113 Total Number 118 Disease Relevance 62.47 Pain Relevance 14.57

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA) nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)

Anatomy Link Frequency stroma 2 plasma 1 hepatocyte 1 colon 1 MCF-7 1 PPARA (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 1530 100.00 COX2 178 100.00 antagonist 171 100.00 Adalimumab 73 100.00 addiction 8 100.00 Inflammation 1156 99.98 rheumatoid arthritis 79 99.56 ischemia 78 99.14 Multiple sclerosis 19 99.08 Osteoarthritis 459 98.56

Disease Link Frequency Relevance Heat Cancer 2305 100.00 Disease 690 100.00 INFLAMMATION 1423 99.98 Skin Cancer 153 99.84 Dyslipidemia / Combined Dyslipidemia 76 99.76 Insulin Resistance 150 99.68 Obesity 1308 99.60 Rheumatoid Arthritis 110 99.56 Chronic Disease 5 99.56 Nasal Polyps 47 99.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, Vldlr was shown to be under control of PPAR?

Regulation (control) of PPAR

1) Confidence 0.60 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.44 Pain Relevance 0.10

The DNA response element conferring PPAR regulation was located to intron 3 of the Angptl4 gene [127].

Regulation (regulation) of PPAR

2) Confidence 0.60 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.28 Pain Relevance 0.10

the control of PPAR transcriptional activity.

Regulation (control) of PPAR

3) Confidence 0.59 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0 Pain Relevance 0

Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression.

Regulation (Effects) of peroxisome proliferator-activated receptor-alpha

4) Confidence 0.56 Published 2005 Journal J. Biochem. Mol. Toxicol. Section Title Doc Link 16292757 Disease Relevance 0.08 Pain Relevance 0.07

regulation of PPAR?

Regulation (regulation) of PPAR

5) Confidence 0.53 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.09 Pain Relevance 0

Promoter analysis of the human UGT1A3 gene revealed coregulation by two lipid-sensing transcription factors, LXR [126] and PPAR?

Regulation (coregulation) of PPAR

6) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.34 Pain Relevance 0

Posttranslational modifications regulate PPAR?

Regulation (regulate) of PPAR

7) Confidence 0.46 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.08 Pain Relevance 0

The effects of PPAR ligands on neuroinflammation in animal models suggest their possible use for treating human inflammatory pain and neuropathic pain.

Regulation (effects) of PPAR associated with ipn and neuropathic pain

8) Confidence 0.45 Published 2009 Journal Int. Rev. Neurobiol. Section Abstract Doc Link 19607969 Disease Relevance 1.18 Pain Relevance 0.98

Other genes involved in cholesterol uptake and transport that were shown to be under control of PPAR?

Regulation (control) of PPAR

9) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.17 Pain Relevance 0.27

Overall, these data suggest that Vnn1 represents a direct PPAR?

Regulation (direct) of PPAR

10) Confidence 0.44 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.55 Pain Relevance 0.18

Having confirmed the bioinformatics in a multi-racial human cohort, the next step was to determine if there were any effects of the PPARA promoter SNP on transcription factor binding and transcriptional activity.

Regulation (effects) of PPARA

11) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0 Pain Relevance 0

Agents that specifically target proteins, transcription factors or ion channels, including PKC agonists/antagonists, PPAR, Phosphodiesterase-5 inhibitors, 3-Hydroxy-3-methyl glutaryl coenzyme A reductase and the ATP-dependent potassium channel are also promising.

Regulation (target) of PPAR associated with antagonist, agonist and potassium channel

12) Confidence 0.44 Published 2007 Journal Expert Opin Emerg Drugs Section Abstract Doc Link 17874967 Disease Relevance 0.55 Pain Relevance 0.41

This study was designed to investigate the effect of fenofibrate, a PPAR-?

Spec (investigate) Regulation (effect) of PPAR

13) Confidence 0.44 Published 2010 Journal Experimental Diabetes Research Section Abstract Doc Link PMC3014714 Disease Relevance 0.95 Pain Relevance 0.14

Taken together, these results suggest that tissue-specific regulation of PPAR?

Regulation (regulation) of PPAR

14) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 1.25 Pain Relevance 0.30

suggest that anti-inflammatory effects of PPAR agonist are likely

Regulation (effects) of PPAR associated with inflammation and agonist

15) Confidence 0.43 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551585 Disease Relevance 1.09 Pain Relevance 0.62

also been noted, suggesting a deregulation of PPAR?

Regulation (deregulation) of PPAR

16) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.51 Pain Relevance 0.04

The PPAR regulation of

Regulation (regulation) of PPAR

17) Confidence 0.43 Published 2008 Journal PPAR Research Section Body Doc Link PMC2234353 Disease Relevance 0.59 Pain Relevance 0.05

The down-regulation of PPAR?

Regulation (regulation) of PPAR

18) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 1.16 Pain Relevance 0.32

anti-inflammatory role of this receptor, PPAR?

Regulation (role) of PPAR associated with inflammation

19) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.25 Pain Relevance 0.42

dependent on PPAR?

Regulation (dependent) of PPAR

20) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.85 Pain Relevance 0

General Comments

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