INT103133

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.26
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, IL8) extracellular space (TNF, IL8) extracellular region (TNF, IL8)
intracellular (TNF, IL8) plasma membrane (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
joint 2
TNF (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
qutenza 6 97.12 Very High Very High Very High
rheumatoid arthritis 121 90.04 High High
antagonist 1 85.60 High High
Inflammation 30 69.52 Quite High
Infliximab 5 58.24 Quite High
Arthritis 10 56.16 Quite High
Etanercept 1 53.52 Quite High
Pain 2 44.24 Quite Low
methotrexate 1 30.32 Quite Low
Disease Link Frequency Relevance Heat
Skin Cancer 8 99.84 Very High Very High Very High
Rheumatoid Arthritis 121 90.04 High High
Necrosis 3 87.24 High High
Cancer 3 86.88 High High
INFLAMMATION 27 69.52 Quite High
Arthritis 10 56.16 Quite High
Disease 13 53.44 Quite High
Apoptosis 5 50.00 Quite Low
Pain 2 44.24 Quite Low
Adhesions 28 15.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.
TNF-alpha Positive_regulation (induced) of Gene_expression (expression) of IL-8 associated with qutenza and skin cancer
1) Confidence 0.48 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.65 Pain Relevance 0.39
IL-1 and TNF stimulate the production of degradative proteases and cytokines such as IL-1, IL-6, IL-8 and MCP-1 by joint tissue cells, contributing to joint destruction.
TNF Positive_regulation (stimulate) of Gene_expression (production) of IL-8 in joint associated with cytokine
2) Confidence 0.17 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.61 Pain Relevance 0.57

General Comments

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