INT103134

Context Info Confidence 0.07 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.43 Pain Relevance 0.70

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)

DCSTAMP (Homo sapiens) NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat qutenza 6 99.16 cytokine 7 83.44 Inflammatory mediators 1 80.52 endometriosis 1 77.76 Pain 1 74.36 Inflammation 1 26.88

Disease Link Frequency Relevance Heat Skin Cancer 8 98.74 Endometriosis 5 94.04 Cancer 2 89.64 INFLAMMATION 2 80.12 Sleep Initiation And Maintenance Disorders 1 75.08 Pain 1 74.36 Disease 1 73.84 Necrosis 1 68.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Electrophoretic mobility shift assay revealed that treatment of these cultures with the urinary preparation hCG-A suppressed TNF-alpha- or IL-1beta-induced NF-kappaB DNA-binding activity, whereas another urinary hCG preparation (hCG-B) was less effective.

IL-1beta-induced Positive_regulation (induced) of NF-kappaB

1) Confidence 0.07 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.71 Pain Relevance 0.27

Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.

IL-1beta-induced Positive_regulation (induced) of NF-kappaB associated with qutenza and skin cancer

2) Confidence 0.07 Published 2002 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 12034025 Disease Relevance 0.72 Pain Relevance 0.43

General Comments

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