INT103148

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.43
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr1b) plasma membrane (Agtr1b) response to stress (Agtr1b)
signal transducer activity (Agtr1b)
Anatomy Link Frequency
PAG 1
uterus 1
Agtr1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 16 99.92 Very High Very High Very High
allodynia 5 93.50 High High
Antinociceptive 1 91.88 High High
Potency 2 88.16 High High
Central grey 4 78.68 Quite High
tail-flick 2 67.08 Quite High
medulla 17 65.76 Quite High
antagonist 1 57.60 Quite High
Dismenorea 1 50.56 Quite High
antinociception 2 47.24 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 98.66 Very High Very High Very High
Nociception 4 98.10 Very High Very High Very High
Neuropathic Pain 5 93.50 High High
Dysmenorrhea 1 50.56 Quite High
Muscle Hypertonia 14 5.00 Very Low Very Low Very Low
Body Weight 5 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 1 5.00 Very Low Very Low Very Low
Lifespan 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of AT1 and AT2 receptor subtypes in the response of the isolated rat uterus to angiotensin II (AngII) was studied throughout the estrous cycle.
Regulation (involvement) of AT1 in uterus
1) Confidence 0.35 Published 2002 Journal Pharmacology Section Abstract Doc Link 12037380 Disease Relevance 0.05 Pain Relevance 0.09
Taken together, the antinociceptive effect of Ang II injection into the ventrolateral PAG, the increase of allodynia elicited by injecting either losartan or CGP42,112A alone in the PAG, and the presence of AT1 and AT2 receptors in neurons and neuronal processes in the same region, represent the first evidence that part of the tonic nociceptive control mediated by the PAG is carried out locally by endogenous Ang II and/or an Ang-peptide acting on AT1 and AT2 receptors.
Regulation (acting) of AT1 in PAG associated with nociception, allodynia, urological neuroanatomy and antinociceptive
2) Confidence 0.22 Published 2005 Journal Neuroscience Section Abstract Doc Link 15802196 Disease Relevance 1.30 Pain Relevance 0.56
After visual inspection of the tracing data, seven medullary and pontine structures known to modulate behavioral state regulation in adults (the Gi, PC, SubLC, LC, PO, LDT, and DR) were selected for analysis.
Regulation (modulate) of SubLC associated with locus ceruleus
3) Confidence 0.03 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1079781 Disease Relevance 0.08 Pain Relevance 0.18

General Comments

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