INT103153

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 22.16
Pain Relevance 4.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cell 7
platelet 4
cochlea 2
embryos 2
macrophage 2
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 163 99.98 Very High Very High Very High
palliative 96 99.30 Very High Very High Very High
cytokine 61 98.88 Very High Very High Very High
Inflammation 36 98.80 Very High Very High Very High
dexamethasone 115 96.24 Very High Very High Very High
Sciatic nerve 6 94.80 High High
ischemia 17 93.68 High High
chemokine 1 90.80 High High
Angina 62 87.16 High High
hypoalgesia 15 84.80 Quite High
Disease Link Frequency Relevance Heat
Cancer 723 100.00 Very High Very High Very High
Hypoxia 70 100.00 Very High Very High Very High
Glioma 55 100.00 Very High Very High Very High
Diabetes Mellitus 382 99.96 Very High Very High Very High
Cervical Cancer 30 99.84 Very High Very High Very High
Ulcers 54 99.74 Very High Very High Very High
Hepatocellular Cancer 130 99.48 Very High Very High Very High
Intervertebral Disk Displacement 9 99.48 Very High Very High Very High
INFLAMMATION 41 98.80 Very High Very High Very High
Hypoglycemia 2 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a co-culture system comprised of murine peritoneal macrophages and intervertebral disc tissue as a model of the acute phase of HD developed previously, an increase in macrophage VEGF protein and mRNA expression was observed upon exposure to disc tissue.
Positive_regulation (increase) of Transcription (expression) of VEGF protein in macrophage associated with intervertebral disk displacement
1) Confidence 0.69 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12038611 Disease Relevance 0.97 Pain Relevance 0.28
Hypoxia-induced transcription of VEGF mRNA is mediated by binding of hypoxia-inducible factor 1 (HIF-1) [7].
Positive_regulation (-) of Transcription (transcription) of VEGF associated with hypoxia
2) Confidence 0.68 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.36 Pain Relevance 0.05
We observed no significant deviation from the untreated mRNA levels for VEGF and bFGF during a 48 hour period after treatment with glucose alone or in combination with fluvastatin.
Neg (no) Positive_regulation (deviation) of Transcription (levels) of VEGF
3) Confidence 0.48 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.38 Pain Relevance 0.16
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Positive_regulation (for) of Transcription (Quantitation) of VEGF
4) Confidence 0.48 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.40 Pain Relevance 0.22
Hypoxia-induced transcription of VEGF mRNA is mediated by binding of hypoxia-inducible factor 1 (HIF-1) [7].
Positive_regulation (induced) of Transcription (transcription) of VEGF associated with hypoxia
5) Confidence 0.45 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.36 Pain Relevance 0.05
One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40
Positive_regulation (gliomas.38,39) of Transcription (expression) of VEGF associated with hypoxia and glioma
6) Confidence 0.45 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 1.00 Pain Relevance 0.08
Furthermore, cell line models suggest that estrogen may have pro-angiogenic effects by increasing VEGF gene transcription [16], while increased VEGF receptor signaling may promote endocrine resistance [17].
Positive_regulation (increasing) of Transcription (transcription) of VEGF gene
7) Confidence 0.35 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.47 Pain Relevance 0
Capillary proliferation was not yet evident, but VEGF mRNA and protein levels were elevated 1.5- and 8-fold, respectively (p< 0.05).
Positive_regulation (elevated) of Transcription (levels) of VEGF in Capillary
8) Confidence 0.30 Published 2003 Journal Jpn. J. Physiol. Section Abstract Doc Link 14529579 Disease Relevance 0.44 Pain Relevance 0.11
VEGF mRNA expression remained constant upon exposure to LTA, which suggests that VEGF regulation in these cells is primarily post-transcriptional.
Positive_regulation (constant) of Transcription (expression) of VEGF
9) Confidence 0.28 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12766200 Disease Relevance 0.22 Pain Relevance 0.15
The maximum increases in VEGF mRNA levels were observed after treatment with 0.1 mg/ml EP2 and 0.01 mg/ml EP4, similar to the VEGF protein levels.
Positive_regulation (increases) of Transcription (levels) of VEGF
10) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.33
The expression of EP2 occurred in the cochlea, and the local application of an EP2 or EP4 agonist increased VEGF protein and VEGF mRNA levels in the inner ear.
Positive_regulation (increased) of Transcription (levels) of VEGF in cochlea associated with agonist
11) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2847564 Disease Relevance 0.31 Pain Relevance 0.21
ELISA and real-time qRT-PCR analyses demonstrated an increase of VEGF protein and mRNA levels in the inner ear after local EP2 or EP4 agonist application, indicating that the stimulation of EP2 and/or EP4 activates VEGF production in the inner ear.
Positive_regulation (increase) of Transcription (levels) of VEGF in inner ear associated with agonist
12) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.27 Pain Relevance 0.23
Hypoxia-inducible factor-1 production leads to increased vascular endothelial growth factor (VEGF) transcription.2 VEGF causes increased vessel permeability and endothelial cell migration and proliferation.
Positive_regulation (increased) of Transcription (transcription.2) of VEGF in endothelial cell associated with hypoxia
13) Confidence 0.25 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895781 Disease Relevance 0.80 Pain Relevance 0
Hypoxia-inducible factor-1 production leads to increased vascular endothelial growth factor (VEGF) transcription.2 VEGF causes increased vessel permeability and endothelial cell migration and proliferation.
Positive_regulation (increased) of Transcription (transcription.2) of vascular endothelial growth factor in endothelial cell associated with hypoxia
14) Confidence 0.25 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895781 Disease Relevance 0.80 Pain Relevance 0
VEGF mRNA levels were rescued by the GGOH mevalonate pathway intermediate at the low alendronate dose whereas neither intermediate consistently restored the VEGF mRNA levels at the high alendronate dose.
Neg (neither) Positive_regulation (restored) of Neg (neither) Transcription (levels) of VEGF
15) Confidence 0.25 Published 2009 Journal The Open Orthopaedics Journal Section Abstract Doc Link PMC2761671 Disease Relevance 0 Pain Relevance 0
The transcriptional activity of the Cox-2 and VEGF promoters was evaluated in cervical cancer cell lines with and without anti-inflammatory reagents sodium salicylate, dexamethasone, salicylic acid and TGF-?
Positive_regulation (evaluated) of Transcription (activity) of VEGF associated with cervical cancer, inflammation and dexamethasone
16) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500220 Disease Relevance 0.80 Pain Relevance 0.26
The treatment with SK-MS10 for 7 and 14 days significantly accelerated ulcer healing and increased the expression of mRNA (at day 7) as well as VEGF protein (at day 14) compared to the vehicle-treated rats.
Positive_regulation (increased) of Transcription (expression) of VEGF protein associated with ulcers
17) Confidence 0.19 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2877244 Disease Relevance 0.51 Pain Relevance 0
-mediated transcription of VEGF by ET-1 under normoxic conditions points to a general mechanism through which oncogenes and growth factors might upregulate VEGF, and could synergize with hypoxia during tumor growth.
Positive_regulation (mediated) of Transcription (transcription) of VEGF associated with cancer and hypoxia
18) Confidence 0.15 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.10 Pain Relevance 0.08
The increased pulmonary metastatic nodules were found in the palliative resection group (14.3 ± 4.7) compared to controls (8.7 ± 3.6), which may be partially due to breakdown of tumor MMP2/TIMP2 balance and in situ up-regulation of VEGF that was consistent with a recent report that confirmed increased VEGF transcription in residual HCC after hepatectomy in a small animal model [25].
Positive_regulation (increased) of Transcription (transcription) of VEGF in nodules associated with cancer, hepatocellular cancer and palliative
19) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.08 Pain Relevance 0.65
Moreover, osmotic stimulus was found to increase the expression of VEGF mRNA in the only SON neurons.
Positive_regulation (increase) of Transcription (expression) of VEGF in neurons
20) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079868 Disease Relevance 0.17 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox