INT103154

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Context Info
Confidence 0.76
First Reported 2002
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 138
Total Number 143
Disease Relevance 58.50
Pain Relevance 7.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FLT1) endosome (FLT1) Golgi apparatus (FLT1)
cytoplasm (FLT1) extracellular space (FLT1) extracellular region (FLT1)
Anatomy Link Frequency
plasma 19
blood 9
placenta 8
mononuclear cells 7
endothelial cells 6
FLT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 100.00 Very High Very High Very High
imagery 356 99.66 Very High Very High Very High
positron emission tomography 582 99.64 Very High Very High Very High
headache 33 99.48 Very High Very High Very High
cytokine 128 98.78 Very High Very High Very High
Inflammation 322 98.64 Very High Very High Very High
ischemia 156 98.00 Very High Very High Very High
Restless leg syndrome 49 97.08 Very High Very High Very High
Clonidine 7 97.04 Very High Very High Very High
antagonist 184 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibromyalgia 137 100.00 Very High Very High Very High
Pancreatic Cancer 22 100.00 Very High Very High Very High
Pancreatitis 2 100.00 Very High Very High Very High
Ectopic Pregnancy 95 99.96 Very High Very High Very High
Cancer 2467 99.84 Very High Very High Very High
Peripheral Arterial Disease 896 99.82 Very High Very High Very High
Hypertension 226 99.80 Very High Very High Very High
Hodgkin's Disease 55 99.78 Very High Very High Very High
Inflammatory Breast Neoplasms 279 99.56 Very High Very High Very High
Pressure And Volume Under Development 124 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As trophoblast cells, which also express Flt-1, are fetal of origin, the role of fetal Flt-1 (TG)n polymorphism needs also to be examined in the risk of preeclampsia.
Gene_expression (express) of Flt-1 in trophoblast cells associated with pre-eclampsia
1) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.66 Pain Relevance 0
Third, the production of the soluble, alternatively spliced Flt-1, sFlt-1, is significantly higher in preeclamptic patients compared with normotensive pregnant women [28].
Gene_expression (production) of Flt-1
2) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.16 Pain Relevance 0
During placental development, the expression of the Flt-1 gene is not only detected in vascular endothelial cells, but also in the developing trophoblasts [10].
Gene_expression (expression) of Flt-1 gene in endothelial cells
3) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.07 Pain Relevance 0
Most of the Flt-1 produced in the mouse and human placenta during later stages of gestation is the soluble form (sFlt-1) generated by alternative splicing of Flt-1, leading to a premature termination after the sixth Ig-like domain [30]. sFlt-1 binds both VEGF and PlGF and acts as a soluble antagonist of their action.
Gene_expression (produced) of Flt-1 in placenta associated with antagonist
4) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.50 Pain Relevance 0.04
Third, the production of the soluble, alternatively spliced Flt-1, sFlt-1, is significantly higher in preeclamptic patients compared with normotensive pregnant women [28].
Gene_expression (production) of sFlt-1
5) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.16 Pain Relevance 0
Secondly, decreased Flt-1 expression has been shown in the placental bed of preeclamptic patients [27].
Gene_expression (expression) of Flt-1
6) Confidence 0.76 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.23 Pain Relevance 0
If luminal expression of VEGFR1 is considered in the future, luminal secretion of sVEGFR1 should be simultaneously investigated as well.
Gene_expression (expression) of VEGFR1
7) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0.09 Pain Relevance 0
Among the four epidermal growth factors, 18 angiogenic genes and six cytokines, only seven genes (namely IL-8, VEGF, bFGF, angiopoietin 1, flt-1, Tie-2 and Tie-1) are overexpressed in WIBC-9 when compared with non-inflammatory models [37].
Gene_expression (overexpressed) of flt-1 associated with inflammation and cytokine
8) Confidence 0.68 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.26 Pain Relevance 0.20
However, other major angiogenic genes (VEGF2, VEGF3, VEGF4, VEGFR1, VEGFR2, and VEGFR3) had similar expression levels in IBC and non-IBC [31].


Gene_expression (expression) of VEGFR1 associated with inflammatory breast neoplasms
9) Confidence 0.68 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.46 Pain Relevance 0.05
Baseline sFlt-1 production was higher in placentas from women with pre-eclampsia than from normal pregnancy (4.5 +/- 1.4 vs 3.2 +/- 0.6 ng/mg of total protein, respectively; P < 0.001), as was sEng production (9.0 +/- 2.3 vs 4.1 +/- 0.6 ng/mg of total protein, respectively; P < 0.001).
Gene_expression (production) of sFlt-1 in placentas associated with eclampsia
10) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.53 Pain Relevance 0.08
In conclusion, placental sFlt-1 and sEng production was higher in pre-eclampsia and antihypertensive drugs had no effect on placental production of sFlt-1 and sEng in vitro.
Gene_expression (production) of sFlt-1 associated with eclampsia
11) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.48 Pain Relevance 0.05
With the exception of frusemide, none of the antihypertensive drugs tested had any effect on sFlt-1 and sEng production from placental explants of normal pregnancy and women with pre-eclampsia.
Gene_expression (production) of sFlt-1 associated with eclampsia
12) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.41 Pain Relevance 0.06
The aim of the present study was to examine whether the antihypertensive drugs clonidine (0.08-1.3 microg/mL), diazoxide (25-300 microg/mL), frusemide (60-1000 microg/mL) and hydralazine (6.3-100 microg/mL) have any effect on placental production of sFlt-1 and sEng in placentas from normal and pre-eclamptic pregnancies. 3.
Gene_expression (production) of sFlt-1 in placentas associated with clonidine
13) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.45 Pain Relevance 0.10
In conclusion, placental sFlt-1 and sEng production was higher in pre-eclampsia and antihypertensive drugs had no effect on placental production of sFlt-1 and sEng in vitro.
Gene_expression (production) of sFlt-1 associated with eclampsia
14) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.49 Pain Relevance 0.05
Effects of anti-hypertensive drugs on production of soluble fms-like tyrosine kinase 1 and soluble endoglin from human normal and pre-eclamptic placentas in vitro.
Gene_expression (production) of soluble fms-like tyrosine kinase 1 in placentas associated with fibromyalgia and hypertension
15) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 19215236 Disease Relevance 0.50 Pain Relevance 0.07
Placental sFlt-1 and sEng production was examined using ELISA. 4.
Spec (examined) Gene_expression (production) of sFlt-1
16) Confidence 0.66 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19215236 Disease Relevance 0.52 Pain Relevance 0.08
18F-FLT was synthesized according to the method developed by Grierson et al. [7,8] with a minimum acceptable specific activity of 0.1 Ci/?
Gene_expression (synthesized) of FLT
17) Confidence 0.66 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.25 Pain Relevance 0.19
We have previously shown that sFlt-1 levels in the second trimester maternal plasma are significantly higher in women with preeclampsia than in normal pregnant women [33]; however, we were unable to demonstrate an association between the d(TG)n polymorphism in the 3' non-coding region of the Flt-1 gene and sFlt-1 levels.
Gene_expression (levels) of sFlt-1 in plasma associated with pre-eclampsia
18) Confidence 0.66 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.61 Pain Relevance 0.04
Most of the Flt-1 produced in the mouse and human placenta during later stages of gestation is the soluble form (sFlt-1) generated by alternative splicing of Flt-1, leading to a premature termination after the sixth Ig-like domain [30]. sFlt-1 binds both VEGF and PlGF and acts as a soluble antagonist of their action.
Gene_expression (produced) of Flt-1 in placenta associated with antagonist
19) Confidence 0.66 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.50 Pain Relevance 0.04
Flt-1 misregulation in peripheral blood mononuclear cells of pregnant women can result in the over-expression of sFlt-1, which may produce an additional (extra-placental) source of sFlt-1 that contributes to the etiology of preeclampsia [31].
Gene_expression (expression) of sFlt-1 associated with pre-eclampsia
20) Confidence 0.66 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2496902 Disease Relevance 0.62 Pain Relevance 0.05

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