INT103166

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Nalcn) transmembrane transport (Nalcn)
Anatomy Link Frequency
neurons 1
Nalcn (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 3 99.96 Very High Very High Very High
Locus ceruleus 9 99.24 Very High Very High Very High
Opioid 5 98.90 Very High Very High Very High
Enkephalin 1 82.04 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 6 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the acute opioid inhibition of LC neurons is mediated primarily by the activation of G-protein-gated potassium channels and that the cAMP-dependent cation conductance does not contribute significantly to this effect.
Positive_regulation (activation) of G-protein-gated in neurons associated with locus ceruleus, potassium channel and opioid
1) Confidence 0.06 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040038 Disease Relevance 0.50 Pain Relevance 0.95

General Comments

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