INT103169

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 27.75
Pain Relevance 20.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
neurons 7
spinal cord 6
nerve 2
retina 1
brain 1
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 118 99.92 Very High Very High Very High
Dorsal horn 119 99.84 Very High Very High Very High
Inflammation 44 99.82 Very High Very High Very High
long-term potentiation 10 99.74 Very High Very High Very High
gABA 537 99.60 Very High Very High Very High
agonist 78 99.60 Very High Very High Very High
Thermal hyperalgesia 320 99.54 Very High Very High Very High
Sciatic nerve 20 99.44 Very High Very High Very High
intrathecal 9 99.04 Very High Very High Very High
Spinal cord 476 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 99.82 Very High Very High Very High
Injury 243 99.80 Very High Very High Very High
Nervous System Injury 202 99.56 Very High Very High Very High
Hyperalgesia 695 99.54 Very High Very High Very High
Spinal Cord Injury 1159 99.48 Very High Very High Very High
Neuropathic Pain 576 98.64 Very High Very High Very High
Shock 7 98.24 Very High Very High Very High
Nociception 192 98.04 Very High Very High Very High
Ganglion Cysts 8 97.58 Very High Very High Very High
Epilepsy 155 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also found that blockade of endogenous brain-derived neurotrophic factor-tyrosine receptor kinase B pathway inhibited the inflammation-induced KCC2 downregulation.
Negative_regulation (downregulation) of KCC2 in brain associated with inflammation
1) Confidence 0.58 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 1.04 Pain Relevance 1.06
Inhibition of the K-Cl cotransporter (KCC) (furosemide 100 microm) together with TTX was also more effective than TTX alone (84 +/- 14%).
Negative_regulation (Inhibition) of KCC associated with tetrodotoxin
2) Confidence 0.57 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.57 Pain Relevance 0.71
Inhibition of the K-Cl cotransporter (KCC) (furosemide 100 microm) together with TTX was also more effective than TTX alone (84 +/- 14%).
Negative_regulation (Inhibition) of K-Cl cotransporter associated with tetrodotoxin
3) Confidence 0.57 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12736353 Disease Relevance 0.57 Pain Relevance 0.71
In our current study, reduction of KCC2 protein was detected in the epicenter region of the spinal cord on day 14–42 following SCI.
Negative_regulation (reduction) of KCC2 protein in spinal cord associated with spinal cord injury and spinal cord
4) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.79 Pain Relevance 0.26
In contrast, KCC2 protein was decreased on 2 and 7 days post-SCI and significantly fell by ~40% on day 14 post-SCI (p < 0.05, Figure 2B).
Negative_regulation (decreased) of KCC2 protein associated with spinal cord injury
5) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.20 Pain Relevance 0.34
Moreover, inhibition of KCC2 activity in vivo reduces mechanical and thermal nociceptive thresholds in control, and uninjured animals [20].
Negative_regulation (inhibition) of KCC2 associated with nociception
6) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.06 Pain Relevance 0.52
This was accompanied by a concurrent down-regulation of KCC2 protein.
Negative_regulation (regulation) of KCC2 protein
7) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.17 Pain Relevance 1.04
Exposing hippocampal neurons to H2O2 leads to a rapid dephosphorylation of KCC2 protein and a subsequent down-regulation of KCC2 protein [23].
Negative_regulation (regulation) of KCC2 protein in neurons
8) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.71 Pain Relevance 0.22
Palma et al. independently concluded that cell membranes from human epileptic tissue, when injected into Xenopus oocytes, elicited depolarizing GABAAergic currents, which was linked to upregulation of NKCC1 and downregulation of KCC2 [237].
Negative_regulation (downregulation) of KCC2 in oocytes associated with epilepsy
9) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.92 Pain Relevance 0.19
Furosemide, a loop diuretic preferentially inhibiting KCC2 over NKCC1, has been shown to have anticonvulsant activity, but its effect has been linked to a decrease in neuronal synchronization and cell volume regulation [116].
Negative_regulation (inhibiting) of KCC2 in neuronal associated with anticonvulsant
10) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.57 Pain Relevance 0.16
The GABAAergic agonist muscimol increases KCC2 mRNA in male neurons, via activation of voltage sensitive calcium channels and calcium signaling [79, 80]; in contrast, muscimol decreases KCC2 mRNA in female SNR neurons with hyperpolarizing GABAAergic responses [79].
Negative_regulation (decreases) of KCC2 mRNA in neurons associated with calcium channel and agonist
11) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.55
These do not happen in female PN15 SN neurons, in which GABAAergic activation downregulates KCC2 mRNA [79].
Negative_regulation (downregulates) of KCC2 mRNA in neurons
12) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0 Pain Relevance 0.10
Moreover, the injured spinal cord tissues exhibit a significant transient upregulation of NKCC1 protein and a concurrent downregulation of KCC2 protein.
Negative_regulation (downregulation) of KCC2 protein in spinal cord associated with spinal cord injury and spinal cord
13) Confidence 0.43 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20536931 Disease Relevance 0.84 Pain Relevance 0.69
Taken together, these results indicate that peripheral inflammation induces downregulation of KCC2 in the dorsal horn of the spinal cord, which may in turn facilitate the development and/or maintenance of chronic inflammatory pain.
Negative_regulation (downregulation) of KCC2 in spinal cord associated with inflammation, ipn, dorsal horn and spinal cord
14) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 1.04 Pain Relevance 1.13
We found that propofol (30 microM) not only impaired LTP expression but also prevented LTP-accompanied downregulation of KCC2 without affecting the basal transmission of glutamatergic synapses.
Negative_regulation (downregulation) of KCC2 in synapses associated with long-term potentiation
15) Confidence 0.42 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.15 Pain Relevance 0.69
Concurrently, a down-regulation of KCC2 protein was detected during day 2–14 post-SCI.
Negative_regulation (regulation) of KCC2 protein associated with spinal cord injury
16) Confidence 0.42 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2561007 Disease Relevance 1.76 Pain Relevance 0.84
Sustained reduction of KCC2 protein was prominent in epicenter of the spinal cord in TH rats.
Negative_regulation (reduction) of KCC2 protein in spinal cord associated with thermal hyperalgesia and spinal cord
17) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.26 Pain Relevance 0.72
Immunoblotting showed a significant transient up-regulation of NKCC1 protein in epicenter of the rat spinal cord on day 14 post-SCI, which was accompanied by a concurrent down-regulation of KCC2 protein.
Negative_regulation (regulation) of KCC2 protein in spinal cord associated with spinal cord injury and spinal cord
18) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.31 Pain Relevance 0.69
In contrast, TH rats displayed a sustained loss of KCC2 protein, with expression of KCC2 observed to be 34% and 40% of sham in lesion epicenter tissue at days 28 and 35 post-SCI, respectively.
Negative_regulation (loss) of KCC2 protein associated with spinal cord injury and thermal hyperalgesia
19) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.85 Pain Relevance 0.57
After intra-colonic capsaicin injection in mice, NKCC1 plasma membrane expression and phosphorylation are increased in the dorsal spinal cord, although it is unknown whether it is accompanied with KCC2 down-regulation [16].
Spec (whether) Negative_regulation (down-regulation) of KCC2 in spinal cord associated with qutenza and spinal cord
20) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.15 Pain Relevance 1.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox