INT103170

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 17.25
Pain Relevance 14.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
spinal cord 13
neurons 6
plasma 4
neuronal 4
brainstem 3
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 12 100.00 Very High Very High Very High
Spinal cord 319 99.68 Very High Very High Very High
Hippocampus 33 99.68 Very High Very High Very High
Neuronal excitability 12 99.62 Very High Very High Very High
gABA 342 99.60 Very High Very High Very High
medulla 14 99.36 Very High Very High Very High
Inflammation 103 99.32 Very High Very High Very High
Arthritis 10 99.20 Very High Very High Very High
Peripheral nerve injury 16 98.76 Very High Very High Very High
intrathecal 7 98.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 16 99.72 Very High Very High Very High
Nervous System Injury 51 99.56 Very High Very High Very High
INFLAMMATION 285 99.32 Very High Very High Very High
Arthritis 10 99.20 Very High Very High Very High
Generalized Anxiety Disorder 11 98.92 Very High Very High Very High
Spinal Cord Injury 433 98.68 Very High Very High Very High
Convulsion 31 98.52 Very High Very High Very High
Hypersensitivity 18 98.28 Very High Very High Very High
Depression 2 98.22 Very High Very High Very High
Pain 63 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that the expression of KCC2, but not that of NKCC1, was significantly reduced in CFA-injected rats.
Negative_regulation (reduced) of Gene_expression (expression) of KCC2
1) Confidence 0.58 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.95 Pain Relevance 0.86
Reduction in KCC2 expression was shown to lead to increases in intracellular chloride concentration and, in such condition, GABA binding to GABA(A) receptor induces membrane depolarization, provoking neuronal excitation rather than inhibition.
Negative_regulation (Reduction) of Gene_expression (expression) of KCC2 in neuronal associated with gaba
2) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.54 Pain Relevance 0.61
A significant decrease in KCC2 expression was detected by immunohistochemistry in laminae I and II, which was confirmed by immunoblotting.
Negative_regulation (decrease) of Gene_expression (expression) of KCC2
3) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.68 Pain Relevance 0.70
Increased GABA levels, along with decrease in KCC2 expression, may underlie the abnormal neuronal activity detected in the spinal cord of diabetic rats.
Negative_regulation (decrease) of Gene_expression (expression) of KCC2 in spinal cord associated with gaba, diabetes mellitus and spinal cord
4) Confidence 0.57 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.61 Pain Relevance 0.66
A loss of tyrosine phosphorylation of KCC2 and a reduction of surface-expression of KCC2 in the plasma membrane is largely attributable to tyrosine phosphatases [23].
Negative_regulation (reduction) of Gene_expression (expression) of KCC2 in plasma
5) Confidence 0.56 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.77 Pain Relevance 0.25
Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury.
Negative_regulation (Reduction) of Gene_expression (expression) of KCC2 associated with injury
6) Confidence 0.55 Published 2002 Journal J. Neurosci. Section Title Doc Link 12040048 Disease Relevance 0.10 Pain Relevance 0.26
Thus, axotomy led to disruption of [Cl(-)](i) regulation attributable to a decrease of KCC2 expression, elevation of intracellular Cl(-), and an excitatory response to GABA.
Negative_regulation (decrease) of Gene_expression (expression) of KCC2 associated with gaba
7) Confidence 0.55 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040048 Disease Relevance 0.07 Pain Relevance 0.21
In contrast, the KCC2 expression level in dorsal horn neurons declines upon peripheral inflammation caused by complete Freund's adjuvant injection [35].
Negative_regulation (declines) of Gene_expression (expression) of KCC2 in neurons associated with inflammation and dorsal horn neuron
8) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.52 Pain Relevance 0.41
It involves a trans-synaptic reduction in the expression of the potassium-chloride exporter KCC2, and the consequent disruption of anion homeostasis in neurons of lamina I of the superficial dorsal horn, one of the main spinal nociceptive output pathways.
Negative_regulation (reduction) of Gene_expression (expression) of KCC2 in lamina associated with nociception and dorsal horn
9) Confidence 0.43 Published 2003 Journal Nature Section Abstract Doc Link 12931188 Disease Relevance 0.67 Pain Relevance 0.49
Hippocampal kindling of adult mice decreased KCC2 expression in the hippocampus, through activation of the BDNF / trkB pathway [262].
Negative_regulation (decreased) of Gene_expression (expression) of KCC2 in hippocampus associated with hippocampus and bdmf
10) Confidence 0.43 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645547 Disease Relevance 0.70 Pain Relevance 0.27
We found that expression of KCC2-like immunoreactivity (IR) was reduced in lamina I and II in the lumbar spinal cord on the stimulated side in phase 1, and then recovered gradually.
Negative_regulation (reduced) of Gene_expression (expression) of KCC2-like in spinal cord associated with spinal cord
11) Confidence 0.43 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 17007947 Disease Relevance 0.61 Pain Relevance 0.75
Moreover, intrathecal injection of KCC2 antisense oligodeoxynucleotides into naïve rats reduced KCC2 expression in the spinal cord, leading to behavioral hypersensitivity similar to the hyperalgesia induced by peripheral inflammation.
Negative_regulation (reduced) of Gene_expression (expression) of KCC2 in spinal cord associated with hyperalgesia, inflammation, hypersensitivity, spinal cord and intrathecal
12) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 1.06 Pain Relevance 1.10
Moreover, transient increase in NKCC1 protein and down-regulation of KCC2 expression were detected in the spinal cord following SCI.
Negative_regulation (regulation) of Gene_expression (expression) of KCC2 in spinal cord associated with spinal cord injury and spinal cord
13) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.51 Pain Relevance 0.84
Moreover, transient increase in NKCC1 protein and down-regulation of KCC2 expression were detected in the spinal cord following SCI.
Negative_regulation (down) of Gene_expression (expression) of KCC2 in spinal cord associated with spinal cord injury and spinal cord
14) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.51 Pain Relevance 0.86
This data indicate a significant increase in the expression of NKCC1 and, conversely, a decrease in KCC2 expression at the epicenter on day 14 post-SCI (prior to the chronic phase of post-SCI neuropathic hyperalgesia).
Negative_regulation (decrease) of Gene_expression (expression) of KCC2 associated with hyperalgesia, spinal cord injury and neuropathic pain
15) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.41 Pain Relevance 0.36
On the other hand, intraplantar formalin stimulation triggers a significant decrease in KCC2 protein expression without changes in NKCC1 in the rat spinal cord [18].
Negative_regulation (decrease) of Gene_expression (expression) of KCC2 protein in spinal cord associated with spinal cord
16) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.19 Pain Relevance 1.12
A loss of tyrosine phosphorylation of KCC2 and a reduction of surface-expression of KCC2 in the plasma membrane is largely attributable to tyrosine phosphatases [23].
Negative_regulation (reduction) of Gene_expression (expression) of KCC2 in plasma
17) Confidence 0.41 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.77 Pain Relevance 0.22
No or a reduced KCC2 expression leads to a depolarizing (excitatory) action of GABA and glycine.
Negative_regulation (reduced) of Gene_expression (expression) of KCC2 associated with gaba
18) Confidence 0.40 Published 2008 Journal Brain research reviews Section Abstract Doc Link 17949820 Disease Relevance 0.07 Pain Relevance 0.32
First, nerve injury is associated with a loss of KCC2 expression [7] as mentioned above.
Negative_regulation (loss) of Gene_expression (expression) of KCC2 in nerve associated with nervous system injury
19) Confidence 0.40 Published 2007 Journal Mol Pain Section Body Doc Link PMC2093929 Disease Relevance 0.28 Pain Relevance 0.35
After 3 hours of treatment, the efficiency of Cl- accumulation is further enhanced through upregulation of NKCC1 expression and reduced expression of the K+-Cl- co-transporter KCC2.
Negative_regulation (reduced) of Gene_expression (expression) of KCC2
20) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.69 Pain Relevance 0.52

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox