INT103172

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 81
Total Number 85
Disease Relevance 39.45
Pain Relevance 36.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc12a5) intracellular (Slc12a5) transmembrane transport (Slc12a5)
Anatomy Link Frequency
spinal cord 12
neurons 11
neuronal 8
hippocampus 3
plasma 2
Slc12a5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 2479 99.88 Very High Very High Very High
Hyperalgesia 376 99.84 Very High Very High Very High
Arthritis 25 99.84 Very High Very High Very High
dorsal root ganglion 27 99.80 Very High Very High Very High
bDMF 160 99.78 Very High Very High Very High
Spinal cord 684 99.68 Very High Very High Very High
Hippocampus 287 99.68 Very High Very High Very High
Peripheral nervous system 28 99.68 Very High Very High Very High
long-term potentiation 20 99.66 Very High Very High Very High
Neuronal excitability 55 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 14 100.00 Very High Very High Very High
Hyperalgesia 796 99.84 Very High Very High Very High
Arthritis 25 99.84 Very High Very High Very High
Injury 221 99.80 Very High Very High Very High
Spinal Cord Injury 1081 99.56 Very High Very High Very High
Nervous System Injury 117 99.40 Very High Very High Very High
Ganglion Cysts 95 99.32 Very High Very High Very High
INFLAMMATION 834 99.20 Very High Very High Very High
Diabetes Mellitus 22 99.20 Very High Very High Very High
Inflammatory Pain 18 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cation chloride cotransporters, K(+)-Cl(-) cotransporter 2 (KCC2) and Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) are reported to be expressed in the neurons in the spinal cord and regulate intracellular Cl(-) concentration.
Gene_expression (expressed) of KCC2 in spinal cord associated with spinal cord
1) Confidence 0.77 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 17007947 Disease Relevance 0.44 Pain Relevance 0.46
Our results suggest that the expression of KCC2, but not that of NKCC1, was significantly reduced in CFA-injected rats.
Gene_expression (expression) of KCC2
2) Confidence 0.77 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.93 Pain Relevance 0.84
We investigated the expression of potassium-chloride co-transporter 2 (KCC2) and sodium-potassium-chloride co-transporter 1 (NKCC1) in the rat spinal cord after peripheral inflammation induced by complete Freund's adjuvant (CFA) injection.
Spec (investigated) Gene_expression (expression) of KCC2 in spinal cord associated with inflammation and spinal cord
3) Confidence 0.77 Published 2008 Journal Neuroscience Section Abstract Doc Link 18262726 Disease Relevance 0.75 Pain Relevance 0.67
To explore a possible role of KCC2-dependent inhibition in anesthetic-induced impairment of LTP, we used field excitatory postsynaptic potentials (fEPSP) recording and immunoblotting to study the effect of propofol on LTP maintenance and KCC2 expression in CA1 region of rat hippocampal slices.
Gene_expression (expression) of KCC2 associated with long-term potentiation
4) Confidence 0.77 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.16 Pain Relevance 0.63
Thus, enhancement of GABAergic inhibition and suppression of neuronal excitability may account for the sustained expression of KCC2 and the impairment of LTP by propofol.
Gene_expression (expression) of KCC2 in neuronal associated with neuronal excitability, gabaergic and long-term potentiation
5) Confidence 0.77 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 17027780 Disease Relevance 0.12 Pain Relevance 0.68
Reduction in KCC2 expression was shown to lead to increases in intracellular chloride concentration and, in such condition, GABA binding to GABA(A) receptor induces membrane depolarization, provoking neuronal excitation rather than inhibition.
Gene_expression (expression) of KCC2 in neuronal associated with gaba
6) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.54 Pain Relevance 0.61
Increased GABA levels, along with decrease in KCC2 expression, may underlie the abnormal neuronal activity detected in the spinal cord of diabetic rats.
Gene_expression (expression) of KCC2 in spinal cord associated with gaba, diabetes mellitus and spinal cord
7) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.61 Pain Relevance 0.65
A significant decrease in KCC2 expression was detected by immunohistochemistry in laminae I and II, which was confirmed by immunoblotting.
Gene_expression (expression) of KCC2
8) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.68 Pain Relevance 0.69
This study aims to analyse the expression of GABA, its synthesizing enzyme glutamic acid decarboxylase (GAD) and the potassium chloride cotransporter (KCC2), in the spinal dorsal horn of streptozotocin (STZ)-induced diabetic rats.
Gene_expression (synthesizing) of KCC2 in dorsal horn associated with gaba, diabetes mellitus, generalized anxiety disorder and spinal dorsal horn
9) Confidence 0.75 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18457921 Disease Relevance 0.65 Pain Relevance 0.55
This data indicate a significant increase in the expression of NKCC1 and, conversely, a decrease in KCC2 expression at the epicenter on day 14 post-SCI (prior to the chronic phase of post-SCI neuropathic hyperalgesia).
Gene_expression (expression) of KCC2 associated with hyperalgesia, spinal cord injury and neuropathic pain
10) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.40 Pain Relevance 0.35
Both NKCC1 and KCC2 are expressed in spinal cords and function to regulate intracellular Cl- concentration.
Gene_expression (expressed) of KCC2 in spinal cords
11) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.35 Pain Relevance 1.21
These results imply that altered NKCC1 and KCC2 expression may lead to GABAergic derangement and contribute to the induction and maintenance of the chronic neuropathic pain following SCI.
Gene_expression (expression) of KCC2 associated with spinal cord injury, gabaergic and neuropathic pain
12) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.15 Pain Relevance 1.00
A loss of tyrosine phosphorylation of KCC2 and a reduction of surface-expression of KCC2 in the plasma membrane is largely attributable to tyrosine phosphatases [23].
Gene_expression (expression) of KCC2 in plasma
13) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 0.77 Pain Relevance 0.25
There were also no significant changes in KCC2 protein expression in rostral spinal cords on day 2–14 post-SCI (Figure 3B).


Gene_expression (expression) of KCC2 protein in spinal cords associated with spinal cord injury
14) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.79 Pain Relevance 0.55
Expression of NKCC1 and KCC2 following SCI
Gene_expression (Expression) of KCC2 associated with spinal cord injury
15) Confidence 0.75 Published 2008 Journal Mol Pain Section Body Doc Link PMC2561007 Disease Relevance 1.13 Pain Relevance 0.42
Reduction of KCC2 expression and GABAA receptor-mediated excitation after in vivo axonal injury.
Gene_expression (expression) of KCC2 associated with injury
16) Confidence 0.73 Published 2002 Journal J. Neurosci. Section Title Doc Link 12040048 Disease Relevance 0.10 Pain Relevance 0.26
Thus, axotomy led to disruption of [Cl(-)](i) regulation attributable to a decrease of KCC2 expression, elevation of intracellular Cl(-), and an excitatory response to GABA.
Gene_expression (expression) of KCC2 associated with gaba
17) Confidence 0.73 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040048 Disease Relevance 0.07 Pain Relevance 0.21
For DRG neurons, the expression of NKCC1 is well documented [13,22], while the expression of KCC2 is controversial [23,24].
Gene_expression (expression) of KCC2 in neurons
18) Confidence 0.71 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.44 Pain Relevance 0.44
In contrast, the KCC2 expression level in dorsal horn neurons declines upon peripheral inflammation caused by complete Freund's adjuvant injection [35].
Gene_expression (expression) of KCC2 in neurons associated with inflammation and dorsal horn neuron
19) Confidence 0.71 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.51 Pain Relevance 0.38
While the changes in NKCC1 and KCC2 expression are consistent with increased Cl- accumulation, the time course of the expression changes lags behind the rise in [Cl-]i.
Gene_expression (expression) of KCC2
20) Confidence 0.71 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.15 Pain Relevance 0.08

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