INT103179

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.79
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)
Anatomy Link Frequency
neurons 4
Prkaca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 44 100.00 Very High Very High Very High
nMDA receptor 9 97.72 Very High Very High Very High
central sensitization 38 95.28 Very High Very High Very High
Pain 12 94.60 High High
Dorsal column 62 93.00 High High
qutenza 68 92.12 High High
Inflammation 17 91.84 High High
Hyperalgesia 15 90.80 High High
Visceral pain 26 90.24 High High
Kinase C 9 75.36 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

27 90.24 High High
Hyperalgesia 19 75.00 Quite High
Nociception 68 69.44 Quite High
Neuropathic Pain 14 66.72 Quite High
INFLAMMATION 20 51.28 Quite High
Ganglion Cysts 22 50.00 Quite Low
Pain 12 47.60 Quite Low
Stress 1 7.76 Low Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The heat transducer VR-1 is therefore suggested as the molecular target of PKA phosphorylation, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Regulation (target) of Phosphorylation (phosphorylation) of PKA
1) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.24 Pain Relevance 0.28
The heat transducer VR-1 is therefore suggested as the molecular target of PKA phosphorylation, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Regulation (depends) of Phosphorylation (phosphorylation) of PKA
2) Confidence 0.20 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040081 Disease Relevance 0.14 Pain Relevance 0.21
Increased phosphorylation of CREB through the activated PKA was involved in CGRP-induced NK1 receptor gene expression in spinal neurons [46].
Regulation (involved) of Phosphorylation (phosphorylation) of PKA in neurons
3) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584043 Disease Relevance 0.19 Pain Relevance 0.89
These results highlight the impact of PKA-dependent phosphorylation on Ca2+-sensitivity and provide evidence for an interaction between the effects of TnI and MLC-2 phosphorylation.



Regulation (dependent) of Phosphorylation (phosphorylation) of PKA
4) Confidence 0.08 Published 2007 Journal Basic Res Cardiol Section Abstract Doc Link PMC2780643 Disease Relevance 0 Pain Relevance 0.07
It is unclear how phosphorylation of the conserved PKA site changes P2X receptor activity.
Regulation (changes) of Phosphorylation (phosphorylation) of PKA site
5) Confidence 0.08 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.13 Pain Relevance 0.16
It is known that several protein kinases, such as PKC, PKA, PKG, MAPK and CaMKII, affect the responses of dorsal horn neurons through phosphorylation of synaptic receptors and proteins involved in the intracellular signal transduction pathways, and the consequences of this modulation could be central sensitization, long-lasting inhibition, and/or changes in gene expression [23-31,53,54].
Regulation (affect) of Phosphorylation (phosphorylation) of PKA in neurons associated with central sensitization and dorsal horn neuron
6) Confidence 0.06 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.54

General Comments

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