INT103198

Context Info Confidence 0.05 First Reported 2002 Last Reported 2002 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.19 Pain Relevance 0.16

pigmentation (NF1) signal transduction (NF1) nucleus (NF1) intracellular (NF1) extracellular matrix organization (NF1) cytoplasm (NF1)

Anatomy Link Frequency Schwann cells 1 NF1 (Homo sapiens) ras (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 90.40 Pain 1 86.84 Antihistamine 1 65.44

Disease Link Frequency Relevance Heat Watson Syndrome 6 99.70 Neurologic Manifestations 1 87.84 Neurofibroma 4 87.28 Pain 1 86.84 Congenital Anomalies 1 86.60 Plexiform Neurofibroma 5 84.52 Disease 1 79.16 Cancer 2 44.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

There is increasing evidence that loss of NF1 expression in neoplastic Schwann cells is associated with elevated levels of activated RAS, supporting the notion that the NF1 gene product, neurofibromin, acts as a growth regulator by inhibiting ras growth-promoting activity.

neurofibromin Negative_regulation (inhibiting) of ras in Schwann cells associated with watson syndrome

1) Confidence 0.05 Published 2002 Journal Neurology Section Abstract Doc Link 12041525 Disease Relevance 1.19 Pain Relevance 0.16

General Comments

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