INT103199

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Context Info
Confidence 0.13
First Reported 2002
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SIGMAR1) nuclear envelope (SIGMAR1) lipid particle (SIGMAR1)
endoplasmic reticulum (SIGMAR1) plasma membrane (SIGMAR1) nucleus (SIGMAR1)
SIGMAR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
antagonist 1 90.28 High High
fortral 4 85.92 High High
Central nervous system 1 82.88 Quite High
positron emission tomography 3 80.72 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 93.56 High High
Cognitive Disorder 1 53.04 Quite High
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased numbers of both sigma1 and sigma2 receptor subtypes in the aged rats compensate for the lowered affinity, and rather enhanced the radioligand-receptor binding.
Positive_regulation (enhanced) of Positive_regulation (increased) of sigma1
1) Confidence 0.13 Published 2003 Journal Ann Nucl Med Section Abstract Doc Link 12691135 Disease Relevance 0 Pain Relevance 0.20
These results suggest that PREGS increases spontaneous glutamate release via activation of a presynaptic G(i/o)-coupled sigma receptor and an elevation in intracellular Ca2+ levels.
Positive_regulation (increases) of Positive_regulation (activation) of sigma receptor associated with glutamate
2) Confidence 0.07 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12042305 Disease Relevance 0.15 Pain Relevance 0.41

General Comments

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