INT1032

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Context Info
Confidence 0.52
First Reported 1975
Last Reported 2010
Negated 41
Speculated 15
Reported most in Body
Documents 202
Total Number 217
Disease Relevance 54.91
Pain Relevance 53.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 14
neuronal 8
heart 6
smooth muscle 4
brain 4
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 560 100.00 Very High Very High Very High
Action potential 550 100.00 Very High Very High Very High
nMDA receptor 545 100.00 Very High Very High Very High
antagonist 498 100.00 Very High Very High Very High
Pain 258 100.00 Very High Very High Very High
adenocard 176 100.00 Very High Very High Very High
TRP channel 108 100.00 Very High Very High Very High
Analgesic 40 100.00 Very High Very High Very High
fluoxetine 23 100.00 Very High Very High Very High
cINOD 12 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 3723 100.00 Very High Very High Very High
Apoptosis 802 100.00 Very High Very High Very High
Acidosis 779 100.00 Very High Very High Very High
Diabetes Mellitus 503 100.00 Very High Very High Very High
INFLAMMATION 355 100.00 Very High Very High Very High
Injury 214 99.92 Very High Very High Very High
Stress 308 99.88 Very High Very High Very High
Cv Unclassified Under Development 502 99.82 Very High Very High Very High
Endotoxemia 68 99.68 Very High Very High Very High
Pheochromocytoma 16 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the preceding studies, it is clear that although anoxia induces significant changes, Ca2+ regulation does not become totally dysfunctional.
Regulation (regulation) of Ca2 associated with hypoxia
1) Confidence 0.52 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.61 Pain Relevance 0
Effects of anoxic aglycemia on Ca2+ regulation
Regulation (regulation) of Ca2
2) Confidence 0.52 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.60 Pain Relevance 0
In this study, we have investigated the effects of anoxia and anoxic aglycemia on Ca2+ regulation in sensory neurons from rat dorsal root ganglia.
Spec (investigated) Regulation (regulation) of Ca2 in sensory neurons associated with hypoxia
3) Confidence 0.52 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.67 Pain Relevance 0.14
BDPH-SNP synergism remained intact in the absence of external Ca2+, indicating that regulation of Ca2+ influx was not a requirement for the manifestation of this interaction.
Regulation (regulation) of Ca2 in external
4) Confidence 0.52 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19186210 Disease Relevance 0.13 Pain Relevance 0
In the second part of the study, we have compounded the effects of acidosis with anoxia and aglycaemia since these conditions not only accompany ischaemia but can have profound effects upon Ca2+ regulation in sensory neurones [34, 55, 69, 75].
Regulation (regulation) of Ca2 associated with acidosis, hypoxia and cv unclassified under development
5) Confidence 0.51 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 1.34 Pain Relevance 0.16
In addition to the slow circadian modulation of [Ca2+]c, there have been reports on Ca2+ spikes that have a duration in the order of several seconds to a minute in SCN neurons.
Regulation (modulation) of Ca2 in neurons
6) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.35
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats.
Regulation (Effects) of Ca2 in spinal associated with nociception and analgesic
7) Confidence 0.44 Published 2001 Journal Pharmacology Section Title Doc Link 11287815 Disease Relevance 0.18 Pain Relevance 0.68
Thus anoxia has multiple effects on [Ca2+]i homeostasis in sensory neurons involving internal stores, mitochondrial buffering, and Ca2+ pumps.
Regulation (effects) of Ca2 in sensory neurons associated with hypoxia
8) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.73 Pain Relevance 0.09
The fundamental components of Ca2+ regulation, however, would probably retain basic functionality.
Regulation (regulation) of Ca2
9) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.33 Pain Relevance 0.07
Having excluded Ca2+ influx as a potential cause of the anoxia induced rise in [Ca2+]i, we sought to determine the role of intracellular Ca2+ stores.
Spec (determine) Regulation (role) of Ca2 associated with hypoxia
10) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0.05
Effects of anoxia on resting [Ca2+]i in DRG neurons
Regulation (Effects) of Ca2 in neurons associated with hypoxia
11) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.40 Pain Relevance 0.10
Because this could not be attributed to an increased mitochondrial Ca2+ load, it must reflect some effect of anoxia on mitochondrial Ca2+ release or cytosolic Ca2+ clearance/extrusion mechanisms.
Regulation (effect) of Ca2 associated with hypoxia
12) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.28 Pain Relevance 0
Hypoxia (pO2: 2 Torr) had no significant effect on [Ca2+]i (n = 16), but anoxia caused an abrupt rise in [Ca2+]i of 66 ± 5 nM to a stable level of 239 ± 9 nM, P < 0.001, n = 49 (see e.g., Fig. 2).
Neg (no) Regulation (effect) of Ca2 associated with hypoxia
13) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.43 Pain Relevance 0.10
Assuming that the basic mechanisms of Ca2+ regulation in dendrites are similar to those in the soma, we would predict a sequence of changes in Ca2+ metabolism in sensory nerve endings during ischemia.
Regulation (regulation) of Ca2 in sensory nerve associated with ischemia
14) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.22 Pain Relevance 0.05
To determine how more complete ATP depletion affects [Ca2+]i regulation, we exposed some neurons to a combination of both anoxia and aglycemia.
Regulation (affects) of Ca2 in neurons associated with hypoxia
15) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.56 Pain Relevance 0
Effects of anoxia on ER Ca2+ release
Regulation (Effects) of Ca2 associated with hypoxia
16) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.73 Pain Relevance 0
Only these neurons were included in our studies on [Ca2+]i regulation.


Regulation (regulation) of Ca2 in neurons
17) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0 Pain Relevance 0.28
Assuming that the basic mechanisms of Ca2+ regulation in dendrites are similar to those in the soma, we would predict a sequence of changes in Ca2+ metabolism in sensory nerve endings during ischemia.
Regulation (changes) of Ca2 in sensory nerve associated with ischemia
18) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.21 Pain Relevance 0.05
Under these conditions, FCCP had negligible effects on measured [Ca2+]i (?
Regulation (effects) of Ca2
19) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.38 Pain Relevance 0.09
In our study, hypoxia had little effect on [Ca2+]i, and the Ca2+ responses to anoxia were not diminished by either Ca2+ channel blocker (Ni2+) or removal of extracellular Ca2+.
Neg (little) Regulation (effect) of Ca2 associated with hypoxia
20) Confidence 0.38 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.81 Pain Relevance 0.21

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