INT10323

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Context Info
Confidence 0.00
First Reported 1990
Last Reported 2006
Negated 2
Speculated 4
Reported most in Abstract
Documents 48
Total Number 52
Disease Relevance 11.76
Pain Relevance 15.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Fam166a) cellular_component (Fam166a) biological_process (Fam166a)
Anatomy Link Frequency
thymocytes 13
brain 3
T lymphocytes 3
PBMC 2
spinal cords 2
Fam166a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 12 99.84 Very High Very High Very High
opioid receptor 49 99.82 Very High Very High Very High
Enkephalin 112 99.80 Very High Very High Very High
corticosteroid 3 99.68 Very High Very High Very High
cytokine 38 99.16 Very High Very High Very High
Ventral tegmentum 2 99.08 Very High Very High Very High
Paracetamol 4 99.00 Very High Very High Very High
antagonist 59 98.96 Very High Very High Very High
Morphine 7 98.80 Very High Very High Very High
Fibrositis 18 98.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 4 99.28 Very High Very High Very High
Overactive Bladder 14 99.08 Very High Very High Very High
Apoptosis 26 99.06 Very High Very High Very High
Injury 17 98.66 Very High Very High Very High
Colon Cancer 6 98.42 Very High Very High Very High
Necrosis 10 97.86 Very High Very High Very High
Sleep Disorders 9 97.08 Very High Very High Very High
Cv Unclassified Under Development 4 96.96 Very High Very High Very High
Neuropathic Pain 9 95.64 Very High Very High Very High
Pain 12 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of SW-480 colon cancer cells with Cel, NS, or NM decreased vascular endothelial growth factor (VEGF) mRNA and immunoreactive protein expression.
Gene_expression (expression) of mRNA in colon associated with colon cancer
1) Confidence 0.00 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15883203 Disease Relevance 0.47 Pain Relevance 0.17
Reverse transcriptase-PCR analysis showed changes in iNOS mRNA levels that paralleled iNOS protein and NO while indicating a lack of effect of either of the kinase inhibitors on TNFalpha mRNA expression.
Gene_expression (expression) of mRNA
2) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9464988 Disease Relevance 0.22 Pain Relevance 0.11
Because of the low expression level of this gene and the limited amount of tissue we developed a sensitive competitive reverse transcription-polymerase chain reaction (RT-PCR) assay for evaluation of levels of kappa OR mRNA in brain tissue.
Gene_expression (expression) of OR mRNA in brain
3) Confidence 0.53 Published 1998 Journal Neuroreport Section Abstract Doc Link 9631448 Disease Relevance 0.32 Pain Relevance 0.18
Our results show that brief TO during late gestation in fetal mice induces accelerated lung development with minimal effects on surfactant protein C mRNA expression.
Gene_expression (expression) of mRNA in lung
4) Confidence 0.44 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618424 Disease Relevance 0.16 Pain Relevance 0.06
However, in situ hybridization showed no significant difference in the density of type II pneumocytes expressing surfactant protein C mRNA.
Gene_expression (expressing) of mRNA in pneumocytes
5) Confidence 0.44 Published 2003 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 12618424 Disease Relevance 0.18 Pain Relevance 0.07
Using in situ hybridization analysis we have now identified the cell types that express PEA mRNA in the reproductive system of female mice.
Gene_expression (express) of mRNA in reproductive system
6) Confidence 0.14 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2325665 Disease Relevance 0 Pain Relevance 0.18
In the uterus, the site of PEA mRNA expression was the deep glandular layer of the endometrium.
Gene_expression (expression) of mRNA in endometrium
7) Confidence 0.14 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2325665 Disease Relevance 0 Pain Relevance 0.15
Both a delta-opioid receptor antagonist, naltrindole, and a PEA mRNA-specific antisense complementary DNA enhance the spontaneous proliferation of day 15, but not day 14, fetal thymocytes, consistent with the observation that PEA mRNA is expressed in thymocytes on day 15, but not day 14, of gestation.
Neg (not) Gene_expression (expressed) of mRNA in thymocytes associated with antagonist and opioid receptor
8) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.41
In recent years we examined the function of the endogenous enkephalins encoded by PEA messenger RNA (mRNA) expressed in murine thymocytes, the precursor cells to T lymphocytes, which are the primary effector cells in cell- mediated immune responses.
Gene_expression (expressed) of mRNA in T lymphocytes associated with enkephalin
9) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.23
In the present study, we examined the expression and function of PEA mRNA and enkephalins in fetal thymocytes.
Spec (examined) Gene_expression (expression) of mRNA in thymocytes associated with enkephalin
10) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.26
By Northern gel and in situ hybridization techniques, we show that PEA mRNA is constitutively expressed in fetal thymocytes early in gestation, with maximal expression occurring on day 15.
Gene_expression (expressed) of mRNA in thymocytes
11) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.26
The data suggest that endogenous enkephalins encoded by PEA mRNA expressed in day 15 fetal thymocytes act to inhibit the spontaneous proliferation of these cells, perhaps so that their differentiation into mature T lymphocytes can occur.
Gene_expression (expressed) of mRNA in thymocytes associated with enkephalin
12) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.40
By birth, PEA mRNA is no longer constitutively expressed, but can be induced by culturing newborn thymocytes with the T cell-specific mitogen, Concanavalin-A.
Neg (no) Gene_expression (expressed) of mRNA in T cell
13) Confidence 0.14 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.38
The detection of proenkephalin A (PEA) mRNA and encoded peptides in various regions of the female reproductive system raised the possibility that opioid peptides might act as local regulators within this system.
Gene_expression (detection) of mRNA in female reproductive system associated with opioid
14) Confidence 0.11 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2325665 Disease Relevance 0 Pain Relevance 0.18
Elevated levels of PEA mRNA were detected predominantly in the vicinity of the implantation site, suggesting that signaling by the implanted embryo play a role in stimulating PEA expression.
Gene_expression (detected) of mRNA in embryo
15) Confidence 0.11 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2325665 Disease Relevance 0 Pain Relevance 0.14
The onset of obstructive voiding patterns correlated with transient increased levels of c-fos and c-myc mRNA by Northern blot analysis.
Gene_expression (levels) of mRNA associated with overactive bladder
16) Confidence 0.08 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1481940 Disease Relevance 1.19 Pain Relevance 0.08
We have studied the expression of PEA mRNA during thymocyte maturation by identifying the subpopulation of thymocytes that expresses PEA mRNA.
Gene_expression (expression) of mRNA in thymocytes
17) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.10
We have studied the expression of PEA mRNA during thymocyte maturation by identifying the subpopulation of thymocytes that expresses PEA mRNA.
Gene_expression (expresses) of mRNA in thymocytes
18) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.09
The regulated expression of PEA mRNA in murine thymocytes, but not in peripheral T lymphocytes, suggests a role for PEA mRNA and its peptides in thymocyte maturation.
Gene_expression (expression) of mRNA in T lymphocytes
19) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.05
Concentrations of mIL-1 beta of 10(-14) and 10(-13) M enhanced the Con-A-induced expression of PEA mRNA in cultured murine thymocytes up to 2.5-fold, whereas higher concentrations of mIL-1 beta (10(-11) and 10(-10) M) inhibited its expression 60 and 85%, respectively.
Gene_expression (expression) of mRNA in thymocytes
20) Confidence 0.02 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263819 Disease Relevance 0 Pain Relevance 0.11

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