INT103235

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry1) aging (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
spinal cord 2
trigeminal nerve 2
P2ry1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
noradrenaline 4 100.00 Very High Very High Very High
Glutamate 4 100.00 Very High Very High Very High
fifth nerve 1 98.66 Very High Very High Very High
antagonist 7 98.00 Very High Very High Very High
Analgesic 1 97.60 Very High Very High Very High
Spinal cord 5 96.60 Very High Very High Very High
dorsal root ganglion 1 92.44 High High
medulla 1 89.16 High High
Neurotransmitter 1 75.00 Quite High
Potency 2 63.20 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 92.44 High High
Headache 1 34.64 Quite Low
Cv Unclassified Under Development 1 33.92 Quite Low
Acidosis 1 32.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results provide evidence that ATP has poor, if at all, direct excitatory effects on CGRP-containing trigeminal nerve endings in the isolated dura and its facilitatory action seems to depend on G-protein coupled P2Y receptors and secondary PGE(2) release.
Regulation (depend) of Localization (release) of P2Y in trigeminal nerve associated with fifth nerve
1) Confidence 0.44 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0 Pain Relevance 0.23
In conclusion, inhibitory P2Y and facilitatory P2X1-like receptors, involved in the regulation of glutamate (P2Y13 and/or P2Y1) and noradrenaline (P2Y13 and/or P2Y1, P2Y12) release have been identified, which provide novel target sites for analgesics acting at the spinal cord level.
Regulation (regulation) of Localization (release) of P2Y1 in spinal cord associated with glutamate, analgesic, noradrenaline and spinal cord
2) Confidence 0.44 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18063000 Disease Relevance 0.09 Pain Relevance 0.74

General Comments

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