INT103236

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Context Info
Confidence 0.54
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.39
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry1) aging (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
neuronal 2
sensory neurons 2
neurons 2
dura mater 2
P2ry1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
hyperexcitability 12 98.12 Very High Very High Very High
Glutamate 3 97.64 Very High Very High Very High
adenocard 45 94.04 High High
dorsal root ganglion 142 92.40 High High
gABA 3 91.84 High High
tissue acidosis 2 90.36 High High
Neuropeptide 3 89.28 High High
ischemia 9 88.20 High High
Migraine 1 87.48 High High
Peripheral nerve injury 6 87.36 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 38 99.00 Very High Very High Very High
Nerve Compression Syndromes 90 93.16 High High
Ganglion Cysts 144 92.40 High High
Acidosis 4 90.08 High High
Cv Unclassified Under Development 7 88.20 High High
Headache 1 87.48 High High
Nervous System Injury 8 86.48 High High
Nociception 14 82.72 Quite High
Hyperalgesia 2 80.64 Quite High
Cv General 3 Under Development 1 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased activation of P2Y1Rs may also contribute to inhibition of neuronal hyperexcitability [24].
Positive_regulation (Increased) of Positive_regulation (activation) of P2Y1Rs in neuronal associated with hyperexcitability
1) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.09 Pain Relevance 0.53
ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.
Positive_regulation (enhance) of Positive_regulation (proton-induced) of P2Y in dura mater
2) Confidence 0.49 Published 2002 Journal Pain Section Title Doc Link 12044622 Disease Relevance 0.27 Pain Relevance 0.21
ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.
Positive_regulation (augments) of Positive_regulation (activation) of P2Y in sensory neurons
3) Confidence 0.49 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12829729 Disease Relevance 0 Pain Relevance 0.31
An alternative that remains to be explored is that increased P2Y1 receptor activation also contributes to the neuropathy-induced blockade of KCl-evoked ATP release.
Positive_regulation (increased) of Positive_regulation (activation) of P2Y1 receptor associated with neuropathic pain
4) Confidence 0.36 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.98 Pain Relevance 0.36
Glutamate release from neurons evokes AMPA- and NMDA-receptor-mediated Ca2+ signaling, whereas ATP released by astrocytes also induces [Ca2+]i elevation via P2Y1 and P2X7 purine receptors in NG2 cells [5], [6].
Positive_regulation (induces) of Positive_regulation (elevation) of P2Y1 in neurons associated with glutamate
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.06 Pain Relevance 0.50

General Comments

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