INT103238

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.16
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
endothelial cells 2
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 1 99.74 Very High Very High Very High
Inflammation 64 98.88 Very High Very High Very High
Thermal hyperalgesia 1 96.76 Very High Very High Very High
Paracetamol 8 96.72 Very High Very High Very High
Osteoarthritis 39 91.00 High High
cytokine 86 90.72 High High
aspirin 1 88.24 High High
metalloproteinase 120 87.52 High High
Migraine 1 84.44 Quite High
ischemia 1 83.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 67 98.88 Very High Very High Very High
Herpes Simplex Virus 238 97.94 Very High Very High Very High
Glioma 2 97.60 Very High Very High Very High
Hyperalgesia 3 96.76 Very High Very High Very High
Sarcoma 79 92.04 High High
Osteoarthritis 51 91.00 High High
Infection 104 89.20 High High
Necrosis 4 85.64 High High
Cancer 24 85.28 High High
Headache 1 84.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of type IIA secretory phospholipase A(2) (sPLA(2)-IIA), cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1), 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and 5-lipoxygenase (5-LO) was quantified by real-time PCR, and these five key enzymes were localized by immunohistochemistry.
Localization (localized) of mPGES-1
1) Confidence 0.68 Published 2010 Journal Hum. Reprod. Section Body Doc Link 20023295 Disease Relevance 0.08 Pain Relevance 0
Telomerase-immortalized human umbilical vein endothelial cells supporting KSHV stable latency (TIVE-LTC) expressed elevated levels of functional COX-2 and microsomal PGE2 synthase (m-PGES), and secreted the predominant eicosanoid inflammatory metabolite PGE2.
Localization (secreted) of m-PGES in endothelial cells associated with inflammation and herpes simplex virus
2) Confidence 0.30 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC2820536 Disease Relevance 1.69 Pain Relevance 0.36
2 may be the result of an autocrine/paracrine feedback loop involving the upregulation of the phospholipase A2/COX/PGES-1 axis and eicosanoid release [3].
Localization (release) of PGES-1
3) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.38 Pain Relevance 0.17
In addition, injecting carrageenan into the hind paw evoked thermal hyperalgesia and the release of prostaglandin E(2) (PGE(2)) from isolated blood vessels of the CNS ex vivo, as well as the induction of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES)-1 and nuclear translocation of signal transducer and activator of transcription 3 (STAT3) in vascular endothelial cells of the CNS.
Localization (translocation) of prostaglandin E synthase in endothelial cells associated with thermal hyperalgesia
4) Confidence 0.05 Published 2007 Journal Neuroscience Section Abstract Doc Link 17303338 Disease Relevance 1.09 Pain Relevance 0.62
We investigated the effect of gamma-mangostin purified from the fruit hull of the medicinal plant Garcinia mangostana on spontaneous prostaglandin E(2) (PGE(2)) genase release and inducible cyclooxy-2 (COX-2) gene expression in C6 rat glioma cells.
Localization (release) of prostaglandin E associated with glioma
5) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.17 Pain Relevance 0
The drug did not affect the expression of the enzymes involved in PGE(2) synthesis, i.e., COX-1, COX-2, and microsomal PGE synthase, or the release of the precursor arachidonic acid (AA).
Localization (release) of microsomal PGE synthase
6) Confidence 0.01 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12605411 Disease Relevance 0.48 Pain Relevance 1.23
The dura was chemically stimulated and the amounts of immunoreactive calcitonin gene-related peptide (iCGRP) and prostaglandin E(2) (PGE(2)) released into incubation fluid were measured using enzyme immunoassays.
Localization (released) of prostaglandin E associated with calcitonin gene-related peptide
7) Confidence 0.01 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0.25 Pain Relevance 0.22

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