INT10324

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Context Info
Confidence 0.00
First Reported 1990
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 2.23
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Fam166a) cellular_component (Fam166a) biological_process (Fam166a)
Anatomy Link Frequency
T cell 2
embryo 1
spinal cords 1
thymocytes 1
AGS 1
Fam166a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 99.64 Very High Very High Very High
allodynia 3 95.64 Very High Very High Very High
long-term potentiation 5 95.52 Very High Very High Very High
Enkephalin 17 92.88 High High
Opioid 2 92.44 High High
opioid receptor 2 92.32 High High
Hippocampus 2 92.20 High High
antagonist 1 91.04 High High
Spinal cord 4 89.36 High High
narcan 3 89.04 High High
Disease Link Frequency Relevance Heat
Alagille Syndrome 3 99.56 Very High Very High Very High
Overactive Bladder 14 99.28 Very High Very High Very High
Neuropathic Pain 3 95.64 Very High Very High Very High
Apoptosis 8 86.96 High High
Hyperplasia 2 85.36 High High
Inflammatory Pain 1 74.20 Quite High
Stress Incontinence 1 70.16 Quite High
Stomach Cancer 1 57.36 Quite High
INFLAMMATION 1 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that at short time periods (1-6 h) after injections of NMDA or sin-1 molsidomine, there is an increase in the levels of the mRNA encoding the alpha subunit of Ca2+/calmodulin-dependent protein kinase II (CaMKII alpha), consistent with a report of elevated CaMKII alpha mRNA in postsynaptic neurons in the CA1 region of the hippocampus following LTP induction [54].
Positive_regulation (increase) of mRNA in hippocampus associated with long-term potentiation and hippocampus
1) Confidence 0.00 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7476022 Disease Relevance 0 Pain Relevance 0.28
Elevated levels of PEA mRNA were detected predominantly in the vicinity of the implantation site, suggesting that signaling by the implanted embryo play a role in stimulating PEA expression.
Positive_regulation (levels) of mRNA in embryo
2) Confidence 0.13 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2325665 Disease Relevance 0 Pain Relevance 0.14
By birth, PEA mRNA is no longer constitutively expressed, but can be induced by culturing newborn thymocytes with the T cell-specific mitogen, Concanavalin-A.
Positive_regulation (induced) of mRNA in T cell
3) Confidence 0.12 Published 1996 Journal Endocrinology Section Abstract Doc Link 8603595 Disease Relevance 0 Pain Relevance 0.38
The onset of obstructive voiding patterns correlated with transient increased levels of c-fos and c-myc mRNA by Northern blot analysis.
Positive_regulation (increased) of mRNA associated with overactive bladder
4) Confidence 0.06 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1481940 Disease Relevance 1.20 Pain Relevance 0.08
PEA mRNA was induced in unfractionated murine thymocytes after in vitro activation of these cells with the T cell mitogen, concanavalin A (Con-A).
Positive_regulation (induced) of mRNA in T cell
5) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.09
In contrast to the action of Con-A on murine thymocytes, PEA mRNA was not induced by this mitogen in murine splenic mononuclear cells at 24, 48, or 72 h.
Neg (not) Positive_regulation (induced) of mRNA in mononuclear cells
6) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.06
A slight induction of PEA mRNA was seen after 48 h of Con-A stimulation; however, the maximal response occurred after 72 h of culture with Con-A.
Positive_regulation (induction) of mRNA
7) Confidence 0.02 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.09
Neither the 1.4 kb nor the 1.7 kb PEA mRNA was induced in the CD8 or double negative subpopulations.
Positive_regulation (induced) of mRNA
8) Confidence 0.01 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.06
Fractionation of thymocytes into CD4, CD8, and double negative subpopulations showed that only the 1.4 kb PEA mRNA was inducible in the mature CD4 subpopulation.
Positive_regulation (inducible) of mRNA in thymocytes
9) Confidence 0.01 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989857 Disease Relevance 0 Pain Relevance 0.07
Both CaMKIIalpha mRNA and protein expression were increased in a time-dependent manner in the spinal cords of wild-type mice after formalin injection.
Positive_regulation (increased) of mRNA in spinal cords
10) Confidence 0.00 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15082179 Disease Relevance 0.24 Pain Relevance 0.71
CaMKII-alpha and -beta mRNA and protein levels in layer IVC of area 17 are subject to activity-dependent regulation, with brief periods of monocular deprivation caused by intraocular injections of tetrodotoxin leading to a 30% increase in CaMKII-alpha mRNA and a comparable decrease in CaMKII-beta mRNA in deprived ocular dominance columns, especially of layer IVCbeta.
Positive_regulation (increase) of mRNA associated with tetrodotoxin
11) Confidence 0.00 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9482799 Disease Relevance 0 Pain Relevance 0.17
A 5-30 min exposure to beta-endorphin resulted in an increase in the rate of mitogen-stimulated intracellular calcium release and an increase in c-myc mRNA levels relative to controls.
Positive_regulation (increase) of mRNA
12) Confidence 0.00 Published 1990 Journal J. Neuroimmunol. Section Abstract Doc Link 2139666 Disease Relevance 0 Pain Relevance 0.20
In AGS cells, a progressive increase in c-myc mRNA and protein levels was noted, while p53 and p21waf1/cip1 remained unchanged.
Positive_regulation (increase) of mRNA in AGS associated with alagille syndrome
13) Confidence 0.00 Published 1999 Journal Biochem. Pharmacol. Section Abstract Doc Link 10403534 Disease Relevance 0.79 Pain Relevance 0

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