INT103240

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.70
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Tyms) methyltransferase activity (Tyms) aging (Tyms)
mRNA binding (Tyms) nucleolus (Tyms) nucleus (Tyms)
Tyms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 3 99.74 Very High Very High Very High
gABA 5 99.32 Very High Very High Very High
Calcium channel 1 92.32 High High
palliative 2 88.88 High High
methotrexate 70 87.32 High High
Glutamate 2 73.16 Quite High
antagonist 2 57.68 Quite High
adenocard 8 57.28 Quite High
Inflammation 3 51.36 Quite High
Arthritis 27 50.00 Quite Low
Disease Link Frequency Relevance Heat
Non-small-cell Lung Cancer 22 98.04 Very High Very High Very High
Lung Cancer 5 97.64 Very High Very High Very High
Malignant Neoplastic Disease 1 96.80 Very High Very High Very High
Toxicity 35 93.00 High High
Colon Cancer 7 92.16 High High
Death 4 79.44 Quite High
Cancer 12 78.72 Quite High
Metastasis 1 71.48 Quite High
Rheumatoid Arthritis 11 69.04 Quite High
INFLAMMATION 2 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of thymidylate synthetase (TYMS), both directly and indirectly via depletion of tetrahydrofolate, leads to inhibition of pyrimidine biosynthesis with a resultant antiproliferative effect [30].
Negative_regulation (Inhibition) of thymidylate synthetase
1) Confidence 0.57 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958653 Disease Relevance 0.33 Pain Relevance 0.35
Tetrodotoxin (TTX) completely inhibited the TsTX action on [(3)H]GABA release.
Negative_regulation (inhibited) of TsTX associated with tetrodotoxin and gaba
2) Confidence 0.11 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12044644 Disease Relevance 0 Pain Relevance 0.55
These include oral 5-fluorouracil analogues, pure thymidylate synthase inhibitors, dihydropyrimidine dehydrogenase inhibitors, and agents with mechanism of action unrelated to thymidylate synthase such as irinotecan, a topoisomerase I inhibitor, and oxaliplatin, the only platinum derivative with significant activity in colorectal cancer.
Negative_regulation (inhibitors) of thymidylate synthase associated with colon cancer
3) Confidence 0.01 Published 2002 Journal Semin. Oncol. Section Abstract Doc Link 12422306 Disease Relevance 0.31 Pain Relevance 0.09
Pemetrexed exerts its cytotoxic effect through inhibition of Thymidylate Synthase, Dihydrofolate Reductase and Glycinamide Ribonucleotide Formyl Transferase [8], which are involved in DNA synthesis and folate metabolism [9].
Negative_regulation (inhibition) of Thymidylate Synthase
4) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529337 Disease Relevance 1.06 Pain Relevance 0

General Comments

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