INT103245

Context Info Confidence 0.68 First Reported 2002 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 64 Total Number 66 Disease Relevance 36.86 Pain Relevance 15.70

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9) proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)

Anatomy Link Frequency chondrocytes 8 neutrophils 8 monocytes 4 plasma 3 mature B cells 3 MMP9 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 817 100.00 intrathecal 70 100.00 cva 34 99.86 cytokine 277 99.20 Inflammation 759 99.12 Chronic pancreatitis 40 98.46 imagery 109 97.84 Osteoarthritis 287 96.68 Multiple sclerosis 202 96.48 Central nervous system 76 96.24

Disease Link Frequency Relevance Heat Major Depressive Disorder 50 100.00 Hemorrhage 61 99.86 Schizophrenia 100 99.84 Disease 325 99.82 Metastasis 131 99.82 Injury 290 99.76 Coronary Artery Disease 70 99.74 Adenocarcinoma 419 99.72 Stomach Cancer 56 99.70 Cancer 807 99.68

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In Fig 4 we show that MMP-9 mRNA expression was increased 6- to 8-fold when stimulated with 10 ?

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 mRNA

1) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

These results indicate a role for PI3K activation in the signalling of both AA and PMA to produce MMP-9.

Positive_regulation (role) of Gene_expression (produce) of MMP-9

2) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

It has been shown that production of MMP-9 is induced by prostaglandin E2 (PGE2), the predominant eicosanoid of macrophages [21].

Positive_regulation (induced) of Gene_expression (production) of MMP-9 in PGE2

3) Confidence 0.68 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.08 Pain Relevance 0.12

As seen in Figure 3, compared with cancer-free controls, increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were detected by Western blot.

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 associated with cancer

4) Confidence 0.63 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 0.78 Pain Relevance 0

Still, the signalling pathways that lead to induction of expression of MMP-9 are incompletely understood.

Positive_regulation (induction) of Gene_expression (expression) of MMP-9

5) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 1.07 Pain Relevance 0.40

This result further points to the involvement of PI3K signalling system in AA-induced MMP-9 production.

Positive_regulation (-) of Gene_expression (production) of MMP-9

6) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.15 Pain Relevance 0

We could show in repeated experiments that the expression level of MMP-9 mRNA increased in response to AA, whereas EPA or DPA did not produce such amplifications.

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 mRNA

7) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Predictably, PMA treatment stimulated MMP-9 expression to a much greater extent than 10 ?

Positive_regulation (stimulated) of Gene_expression (expression) of MMP-9

8) Confidence 0.59 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Western blot analysis demonstrated elevated protein levels of MMP-9, DJ-1 and A1BG in cancerous pancreatic juice compared with cancer-free pancreatic juice, which is consistent with our proteomic findings.

Positive_regulation (elevated) of Gene_expression (levels) of MMP-9 associated with cancer

9) Confidence 0.46 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.51 Pain Relevance 0

The secretion increased due to increased expression of MMP-9 mRNA.

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 mRNA

10) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.12 Pain Relevance 0.03

Supplementation with AA (but not the n-3 fatty acids) increased, in a dose-dependent manner, expression of MMP-9 protein.

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 protein

11) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2667508 Disease Relevance 0.31 Pain Relevance 0.16

The secretion increased due to increased expression of MMP-9 mRNA.

Positive_regulation (increased) of Gene_expression (expression) of MMP-9 mRNA

12) Confidence 0.46 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.07 Pain Relevance 0

Further more, GC patients with negative MMP9 expression displayed improved overall survival compared to patients with positive MMP9 expression (Median OS was 44.0 and 13.5 months, respectively.

Positive_regulation (negative) of Gene_expression (expression) of MMP9 associated with stomach cancer

13) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2965128 Disease Relevance 1.33 Pain Relevance 0.07

Even though some of the BAL macrophages displayed a very weak expression of MMP-9 immunoreactivity, as has previously been reported in a different inflammatory setting [29], we found the most pronounced increase in and expression of MMP-9 immunoreactivity consistently among BAL neutrophils.

Positive_regulation (increase) of Gene_expression (expression) of MMP-9 in neutrophils associated with inflammation and metalloproteinase

14) Confidence 0.44 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.10 Pain Relevance 0.31

MMP-9 production in response to LPS-induced PI3K stimulation has also been reported to occur through IKK?

Positive_regulation (response) of Gene_expression (production) of MMP-9

15) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.30 Pain Relevance 0.07

On the other hand, studies of Lu et al. [28] show that in LPS-activated human peripheral blood monocytes MMP-9 production resulted through the stimulation of PI3K signalling pathway.

Positive_regulation (activated) of Gene_expression (production) of MMP-9 in monocytes

16) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.11 Pain Relevance 0.08

Since EPA, DPA or DHA by themselves had no effect on MMP-9 secretion, we looked at their effect on AA-induced production of MMP-9.

Positive_regulation (induced) of Gene_expression (production) of MMP-9

17) Confidence 0.43 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0

Over-expression of MMP-9 and DJ-1 in pancreatic cancer tissues have been shown in previous studies [10,11].

Positive_regulation (expression) of Gene_expression (expression) of MMP-9 associated with pancreatic cancer

18) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.30 Pain Relevance 0

Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients Background

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MMP-9 associated with adenocarcinoma

19) Confidence 0.42 Published 2008 Journal BMC Cancer Section Title Doc Link PMC2528014 Disease Relevance 0.80 Pain Relevance 0.03

Over-expression of MMP-9 and DJ-1 in pancreatic cancer tissues have been shown in previous studies [10,11].

Positive_regulation (-) of Gene_expression (expression) of MMP-9 associated with pancreatic cancer

20) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2528014 Disease Relevance 1.30 Pain Relevance 0

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