INT103246

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Context Info
Confidence 0.34
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 8.67
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
coronary artery 2
tendons 2
ECM 2
lung 2
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 21 99.90 Very High Very High Very High
Osteoarthritis 163 99.84 Very High Very High Very High
Inflammatory mediators 28 98.88 Very High Very High Very High
corticosteroid 56 98.74 Very High Very High Very High
cytokine 22 98.00 Very High Very High Very High
Inflammation 142 97.80 Very High Very High Very High
Inflammatory response 21 97.60 Very High Very High Very High
aspirin 7 95.00 High High
Potency 1 91.60 High High
imagery 21 88.20 High High
Disease Link Frequency Relevance Heat
Stress 43 99.98 Very High Very High Very High
Osteoarthritis 59 99.84 Very High Very High Very High
Knee Osteoarthritis 48 99.84 Very High Very High Very High
Infection 6 99.24 Very High Very High Very High
Adenocarcinoma 9 98.78 Very High Very High Very High
Injury 98 98.76 Very High Very High Very High
INFLAMMATION 199 98.68 Very High Very High Very High
Intellectual Impairment 2 97.88 Very High Very High Very High
Skin Ulcer 2 97.08 Very High Very High Very High
Prolidase Deficiency 6 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lung adenocarcinoma G1 had a similar collagen content as normal lung tissue but increased amounts of collagen degradation products and free hydroxyproline.
Positive_regulation (increased) of Protein_catabolism (degradation) of collagen in lung associated with adenocarcinoma
1) Confidence 0.34 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.71 Pain Relevance 0.36
Collagen is indeed a core component of the ECM, and undergoes remodeling that is dependent on both continued collagen synthesis and compensatory collagen degradation.
Positive_regulation (dependent) of Protein_catabolism (degradation) of collagen in ECM
2) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481293 Disease Relevance 0.98 Pain Relevance 0.12
The relationship between collagen and prolidase activity was observed during fibrotic processes, where an increase in prolidase activity was accompanied by increase in tissue collagen deposition.27 The negative effect of free radicals is mediated by degradative agents such as proteolytic enzymes and the last step of collagen degradation is mediated by prolidase.12 Surazynski et al. pointed out that prolidase may also have a role in angiogenesis as prolidase deficiency is associated with angiopathy.13 Oxidative stress resulted in collagen degradation and this process is mediated by prolidase.12 Moreover the degree of severity of oxidative stress is directly related to the inhibition of collagen production, and prolidase is thought to be the target enzyme of this process.28 Yildiz et al. showed that increased serum prolidase activity was significantly associated with the presence and severity of coronary artery disease.29 In accordance with their study we have shown that serum prolidase activity is significantly associated with the presence and severity of vasculogenic ED, and elevated serum prolidase activity may be an independent predictor of ED.10 In addition, it was suggested that hypertension and its duration is associated with increased serum prolidase activity and might be useful as a marker for the follow?
Positive_regulation (mediated) of Protein_catabolism (degradation) of collagen in coronary artery associated with stress, fibrosis, prolidase deficiency, coronary artery disease, erectile dysfunction, vascular disease and hypertension
3) Confidence 0.12 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 1.02 Pain Relevance 0.06
Overuse or repetitive stretching on tendons triggered the release of pro-inflammatory mediators, which can induce expression of metalloproteinases and leads to collagen degradation.
Positive_regulation (leads) of Protein_catabolism (degradation) of collagen in tendons associated with inflammatory mediators and metalloproteinase
4) Confidence 0.12 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2770552 Disease Relevance 1.77 Pain Relevance 0.55
Despite these advantages, comparisons of fluorinated versus non-fluorinated corticosteroids have demonstrated various effects by which fluorinated agents increase collagen degradation [52-54].
Positive_regulation (increase) of Protein_catabolism (degradation) of collagen associated with corticosteroid
5) Confidence 0.11 Published 2010 Journal J Foot Ankle Res Section Body Doc Link PMC2912256 Disease Relevance 0.35 Pain Relevance 0.58
Oxidative stress results in collagen degradation and this process is mediated by prolidase.12 Moreover, the degree of severity of oxidative stress is directly related to the inhibition of collagen production, and prolidase is thought to be the target enzyme of this process.20 Our study showed that tadalafil citrate significantly reduced prolidase activity at the peak serum level.
Positive_regulation (results) of Protein_catabolism (degradation) of collagen associated with stress
6) Confidence 0.11 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 1.06 Pain Relevance 0.03
Other evidence supporting a high rate of turnover in advancing OA emanates from studies suggesting that there is increased synthesis and degradation of the subchondral bone collagen in OA, as well as changes to post-translational modifications [11,12]: increased lysine hydroxylation, changes in the nature of the cross-links between the polypeptide chains, and consequent decreased mineralization.
Positive_regulation (increased) of Protein_catabolism (degradation) of collagen associated with osteoarthritis
7) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.92 Pain Relevance 0.46
Under the influence of pro-inflammatory cytokines, increased production and secretion of collagenases such as MMP-3, MMP-13 is the crucial event for enhanced collagen degradation in OA 39.
Positive_regulation (enhanced) of Protein_catabolism (degradation) of collagen associated with inflammation, osteoarthritis and cytokine
8) Confidence 0.02 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.79 Pain Relevance 0.57
This may not represent a major risk if such drugs are administered intraarticularly or for short periods of time, for example, to limit the irreversible collagen degradation in the first few months after injury.
Positive_regulation (limit) of Protein_catabolism (degradation) of collagen associated with injury
9) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.07 Pain Relevance 0.30

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