INT103260

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 23.80
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nps) molecular_function (Nps)
Anatomy Link Frequency
liver 3
hypothalamus 2
projection neurons 2
heart 2
plasma 1
Nps (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 92 99.98 Very High Very High Very High
cva 312 99.96 Very High Very High Very High
projection neuron 90 99.66 Very High Very High Very High
amygdala 303 99.54 Very High Very High Very High
Gabapentin 3 99.44 Very High Very High Very High
parabrachial 10 99.24 Very High Very High Very High
tolerance 4 99.16 Very High Very High Very High
Dorsal horn 4 99.16 Very High Very High Very High
GABAergic 12 99.12 Very High Very High Very High
Sciatica 7 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Syndrome 125 100.00 Very High Very High Very High
Nail-patella Syndrome 10 100.00 Very High Very High Very High
Cancer 110 99.98 Very High Very High Very High
INFLAMMATION 79 99.98 Very High Very High Very High
Pulmonary Embolism 13 99.96 Very High Very High Very High
Stroke 175 99.60 Very High Very High Very High
Nerve Root Compression 5 99.48 Very High Very High Very High
Dyspnea 65 99.36 Very High Very High Very High
Poisoning 39 99.28 Very High Very High Very High
Toxicity 51 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of GABA-mediated sIPSCs in projection neurons may result from activation of NPS receptors located at GABAergic presynaptic terminals, leading to an increase in intracellular Ca2+ as specific for cellular NPS action [1] and thereby to an augmented GABA release.
Positive_regulation (activation) of NPS in projection neurons associated with gaba, gabaergic and projection neuron
1) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.23
The behavioral change in our experiments is likely due to a local effect of NPS through the activation of NPS receptors in the EPN, but we cannot rule out a spreading to the NPSR-endowed lateral enthorhinal cortex.
Positive_regulation (activation) of NPS in cortex
2) Confidence 0.48 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0.69 Pain Relevance 0.22
NPS receptor (NPSR) mRNA was found in the area related to the descending control system of pain, such as the periaqueductal gray (PAG), raphe nuclei, and lateral parabrachial nucleus (PBN), suggesting a possible role of the NPS-NPSR system in the regulation of pain transmission.
Spec (possible) Positive_regulation (role) of NPS in parabrachial nucleus associated with pain, urological neuroanatomy, raphe, central grey and parabrachial
3) Confidence 0.44 Published 2009 Journal Regul. Pept. Section Abstract Doc Link 19345242 Disease Relevance 0.57 Pain Relevance 0.80
Influence of TiO2 NPs on electrical activity of cortical networks
Positive_regulation (Influence) of NPs
4) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
In our study using NPs suspended in serum-free media, we found a high positive zeta potential for TiO2 NPs compared with the negative zeta potential of Fe2O3 and CB NPs.
Positive_regulation (potential) of NPs
5) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0.04
Influence of CB NPs on electrical activity of cortical networks
Positive_regulation (Influence) of NPs
6) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
All three types of NPs induced significant changes of SRs and BRs, whereby CB had the highest efficiency at the lowest particle concentrations, followed by Fe2O3 and TiO2 NPs.
Positive_regulation (induced) of NPs
7) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.16 Pain Relevance 0
The NPs used in our own experiments were relatively large (50–100 nm); thus, it might be that the effects we observed would be even stronger using NPs < 50 nm.
Positive_regulation (using) of NPs
8) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0.06
Influence of Fe2O3 NPs on electrical activity of cortical networks
Positive_regulation (Influence) of NPs
9) Confidence 0.43 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0.09 Pain Relevance 0
Thirdly, disconnection of BLA and EPN prevented the NPS-induced increase of sIPSCs in BLA projection neurons.
Positive_regulation (increase) of NPS in projection neurons associated with projection neuron and amygdala
10) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2442874 Disease Relevance 0 Pain Relevance 0.40
These results are in agreement with the presented data of multicenter randomized placebo-controlled studies of the efficacy and tolerance of gabapentin in the treatment of cancer-induced NPS of various genesis.
Positive_regulation (induced) of NPS associated with syndrome, cancer, tolerance and gabapentin
11) Confidence 0.40 Published 2005 Journal Anesteziol Reanimatol Section Abstract Doc Link 16318049 Disease Relevance 0.82 Pain Relevance 0.60
The dynamic light-scattering analysis demonstrated that NPs suspended in serum-free liquid medium formed agglomerates; because of that, the hydrodynamic diameter increased.
Positive_regulation (increased) of NPs
12) Confidence 0.40 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2957913 Disease Relevance 0 Pain Relevance 0
Several recent publications have evaluated NPs for assessing preoperative risk.
Positive_regulation (evaluated) of NPs
13) Confidence 0.38 Published 2010 Journal Curr Cardiovasc Risk Rep Section Body Doc Link PMC2894089 Disease Relevance 0.31 Pain Relevance 0
NPS is the result of heterozygous loss-of-function mutations in the LIM-homeodomain transcription factor, LMX1B.
Positive_regulation (result) of NPS associated with nail-patella syndrome
14) Confidence 0.38 Published 2005 Journal Eur. J. Hum. Genet. Section Abstract Doc Link 15562281 Disease Relevance 0.59 Pain Relevance 0.07
Unilateral axotomy induced upregulation of galanin in DRG NPs of all sizes in both types of mouse.
Positive_regulation (induced) of NPs
15) Confidence 0.34 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 16546349 Disease Relevance 0.46 Pain Relevance 0.49
ICP-MS analysis revealed the biodistribution of gold nanoparticles in the vital organs showing accumulation of AuNPs in the spleen comparatively greater than other organs.


Positive_regulation (accumulation) of AuNPs in spleen
16) Confidence 0.34 Published 2010 Journal J Nanobiotechnology Section Abstract Doc Link PMC2914719 Disease Relevance 0.67 Pain Relevance 0
Carrageenan-induced peripheral inflammation increased the number of p-Akt-IR NPs after 1 h.
Positive_regulation (increased) of NPs associated with inflammation
17) Confidence 0.31 Published 2009 Journal Neurosignals Section Abstract Doc Link 19346757 Disease Relevance 0.69 Pain Relevance 0.60
A novel mutation in the homeobox transcription factor LMX1B causes NPS in a family with variable expressivity of the syndrome, including OAG.
Positive_regulation (causes) of NPS associated with syndrome and open-angle glaucoma
18) Confidence 0.29 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2669506 Disease Relevance 1.05 Pain Relevance 0
NPS is caused by a mutation in the LMX1B gene that presumably leads to loss of function of the encoding transcription factor, and the clinical phenotype is related to the pleiotropic effect of LMX1B during development [20,21].
Positive_regulation (caused) of NPS associated with syndrome
19) Confidence 0.25 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2669506 Disease Relevance 0.65 Pain Relevance 0
Because a 500 nM concentration of AgNPs was found to be the IC50, further experiments were carried out using this concentration, to show the effect of AgNPs against the tumor under in vitro and in vivo conditions.


Positive_regulation (concentration) of AgNPs associated with cancer
20) Confidence 0.22 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC2962271 Disease Relevance 0.95 Pain Relevance 0

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