INT103261

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2002
Last Reported 2010
Negated 1
Speculated 7
Reported most in Abstract
Documents 68
Total Number 80
Disease Relevance 24.25
Pain Relevance 39.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
neurons 7
optic nerve 4
neuronal 2
Purkinje cells 2
sensory neurons 1
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1070 100.00 Very High Very High Very High
addiction 308 100.00 Very High Very High Very High
Nav1.7 286 100.00 Very High Very High Very High
nav1.8 193 100.00 Very High Very High Very High
Nav1.2 106 100.00 Very High Very High Very High
Nav1.6 76 100.00 Very High Very High Very High
Nav1.1 24 100.00 Very High Very High Very High
Nav1.9 17 100.00 Very High Very High Very High
nav1.3 16 100.00 Very High Very High Very High
Pain threshold 16 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 220 100.00 Very High Very High Very High
Pain 365 99.96 Very High Very High Very High
Multiple Sclerosis 46 99.80 Very High Very High Very High
Erythermalgia 46 99.54 Very High Very High Very High
Colitis 15 99.08 Very High Very High Very High
Ganglion Cysts 502 99.04 Very High Very High Very High
Targeted Disruption 233 98.00 Very High Very High Very High
Somatoform Disorder 30 98.00 Very High Very High Very High
Death 15 97.82 Very High Very High Very High
Demyelinating Disease 23 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At 7 months of age, however, Plp/- mice exhibit severe demyelination and oligodendrocyte cell death, leading to a profound reduction in Nav1.6 clusters, loss of the paranodal axoglial apparatus, and a marked increase in Nav1.2.
Positive_regulation (increase) of Nav1 in oligodendrocyte associated with demyelination, nav1.2, nav1.6 and death
1) Confidence 0.70 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898531 Disease Relevance 0.72 Pain Relevance 0.61
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Positive_regulation (increased) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
2) Confidence 0.69 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.15 Pain Relevance 1.69
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Positive_regulation (increased) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
3) Confidence 0.69 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.16 Pain Relevance 1.69
Our results demonstrate a reduction in the number of secondary spikes per complex spike and irregularity in the temporal organization of secondary spikes in Purkinje cells from mice with EAE in which Nav1.8 is upregulated.
Positive_regulation (upregulated) of Nav1 in Purkinje cells associated with multiple sclerosis and nav1.8
4) Confidence 0.69 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15118796 Disease Relevance 0.84 Pain Relevance 0.60
The expression of Nav1.8 in cultured Purkinje cells has been shown to alter the activity pattern of these cells in vitro by decreasing the number of spikes per conglomerate action potential and by contributing to the production of sustained, pacemaker-like activity upon depolarization, suggesting the hypothesis that, in pathophysiological situations where Nav1.8 is upregulated within Purkinje cells, the pattern of activity in these cells will be altered.
Positive_regulation (upregulated) of Nav1 in Purkinje cells associated with action potential and nav1.8
5) Confidence 0.69 Published 2004 Journal Exp Brain Res Section Abstract Doc Link 15118796 Disease Relevance 0.74 Pain Relevance 0.54
Any functional compensatory upregulation of Nav 1.7, for example, impacting upon the phenotype, would increase neuronal activity, yet we still observed a clear selective reduction in this modality.
Positive_regulation (upregulation) of Nav in neuronal
6) Confidence 0.68 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.20 Pain Relevance 0.09
An embryonic channel (Nav1.3) is also upregulated in damaged peripheral nerves and associated with increased electrical excitability in neuropathic pain states.
Positive_regulation (upregulated) of Nav1 in peripheral nerves associated with nav1.3 and neuropathic pain
7) Confidence 0.68 Published 2004 Journal J. Neurobiol. Section Abstract Doc Link 15362153 Disease Relevance 0.59 Pain Relevance 1.28
It is reported that in the Nav 1.8 knockout there is increased expression of TTX-sensitive currents, but not TTX-resistant, possibly due to an increase in Nav 1.7 [2].
Spec (possibly) Positive_regulation (increase) of Nav associated with targeted disruption
8) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1403745 Disease Relevance 0.10 Pain Relevance 0.12
Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density.
Neg (not) Positive_regulation (required) of Nav1 in nerve associated with nav1.2 and nav1.6
9) Confidence 0.50 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.03
The results in the mutant optic nerves suggested that paranodal junction formation may be necessary for complete replacement of nodal Nav1.2 to Nav1.6 during development as well as maintenance of Nav1.6 clusters at the nodes.
Spec (may) Positive_regulation (necessary) of Nav1 in nodes associated with nav1.2 and nav1.6
10) Confidence 0.50 Published 2004 Journal Glia Section Abstract Doc Link 15048850 Disease Relevance 0.09 Pain Relevance 1.29
The increase is more than the sum of the phenotype in the individual knockouts and may indicate that Nav1.8 and Nav1.7 are the major VGSC isoforms present in nociceptive terminals and their deletion dramatically increases pain threshold.
Positive_regulation (increases) of Nav1 associated with nociception, pain threshold, sodium channel, nav1.8 and nav1.7
11) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.67 Pain Relevance 2.16
The increase is more than the sum of the phenotype in the individual knockouts and may indicate that Nav1.8 and Nav1.7 are the major VGSC isoforms present in nociceptive terminals and their deletion dramatically increases pain threshold.
Positive_regulation (increases) of Nav1 associated with nociception, pain threshold, sodium channel, nav1.8 and nav1.7
12) Confidence 0.50 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.67 Pain Relevance 2.15
The demonstration of its dependence on Nav1.9 provides evidence for a specialized role of Nav1.9, together with Nav1.8, in pain sensation.
Positive_regulation (dependence) of Nav1 associated with pain, addiction, nav1.8 and nav1.9
13) Confidence 0.50 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12046980 Disease Relevance 0.29 Pain Relevance 1.08
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Positive_regulation (increased) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
14) Confidence 0.50 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.17 Pain Relevance 1.74
Together, these findings suggest that colitis alters trkA-positive neurons to preferentially increase slow TTX-R Na+ (Nav1.8) currents.
Positive_regulation (increase) of Nav1 in neurons associated with colitis and nav1.8
15) Confidence 0.49 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15205116 Disease Relevance 0.45 Pain Relevance 0.40
These changes within the optic nerve are paralleled by decreased levels of Nav1.6 and increased Nav1.2 protein, together with increased levels of Nav1.2 mRNA, within retinal ganglion cells in EAE.
Positive_regulation (levels) of Nav1 in optic nerve associated with ganglion cysts, multiple sclerosis, nav1.2 and nav1.6
16) Confidence 0.46 Published 2003 Journal Brain Section Abstract Doc Link 12805113 Disease Relevance 1.15 Pain Relevance 1.68
However, when temperatures become painful Nav1.8 seems to be not only essential to maintain the excitability of nociceptors (Zimmermann et al. 2007), but based on our results the activity of Nav1.8 is also required for nociceptors to detect noxious cold temperatures.
Positive_regulation (required) of Nav1 in nociceptors associated with pain, nociceptor and nav1.8
17) Confidence 0.46 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887988 Disease Relevance 0.15 Pain Relevance 1.43
The slow TTX-R-inactivating Na current density (Nav1.8) was significantly increased, but other Na currents were unaffected.
Positive_regulation (increased) of Nav1 associated with nav1.8
18) Confidence 0.46 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15205116 Disease Relevance 0.52 Pain Relevance 0.61
The cardiac voltage-gated Na+ channel Nav1.5, encoded by SCN5A gene, determines the upstroke velocity of the action potential and, in conjunction with gap junction channels and the organization of the collagenous skeleton, controls the propagation of the cardiac electrical impulse.
Positive_regulation (gated) of Nav1 in skeleton associated with action potential
19) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.25 Pain Relevance 0.05
The voltage dependence of activation of Nav1.7 could be described by a Boltzmann function, with half maximum activation (V0.5) of ?
Positive_regulation (activation) of Nav1.7 associated with addiction and nav1.7
20) Confidence 0.45 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.07 Pain Relevance 0.75

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox