INT103262

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Context Info
Confidence 0.81
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 53
Total Number 55
Disease Relevance 19.23
Pain Relevance 34.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nav1) cytoskeleton (Nav1) cytoplasm (Nav1)
Anatomy Link Frequency
nerve 10
neurons 8
plasma 5
nodes 3
central nervous systems 2
Nav1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1153 100.00 Very High Very High Very High
tetrodotoxin 394 100.00 Very High Very High Very High
Nav1.7 244 100.00 Very High Very High Very High
nav1.8 163 100.00 Very High Very High Very High
Nav1.2 130 100.00 Very High Very High Very High
Nav1.6 85 100.00 Very High Very High Very High
nav1.3 84 100.00 Very High Very High Very High
Nav1.1 37 100.00 Very High Very High Very High
Nav1.9 18 100.00 Very High Very High Very High
nociceptor 120 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 53 99.52 Very High Very High Very High
Ganglion Cysts 500 99.20 Very High Very High Very High
Demyelinating Disease 34 98.92 Very High Very High Very High
Nervous System Injury 37 98.86 Very High Very High Very High
Inflammatory Pain 43 98.00 Very High Very High Very High
Injury 48 97.88 Very High Very High Very High
Targeted Disruption 176 97.20 Very High Very High Very High
Syndrome 48 97.00 Very High Very High Very High
Neuroma 5 96.92 Very High Very High Very High
Multiple Sclerosis 7 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We find that as in control animals, most mutant nodes of Ranvier had Nav1.6 in high-density clusters in the peripheral and central nervous systems; the localization of Nav1.2 and the protein levels of Nav1.2 and Nav1.6 were also normal in the CGT-deficient mouse.
Localization (localization) of Nav1 in central nervous systems associated with nav1.2 and nav1.6
1) Confidence 0.81 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 0.97
Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density.
Localization (localization) of Nav1 in nerve associated with nav1.2 and nav1.6
2) Confidence 0.81 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 1.03
Nav1.8 and Nav1.9 contain an amino acid sequence common to tetrodotoxin resistant Na+ channels and are localized in peripheral nociceptors.
Localization (localized) of Nav1 in nociceptors associated with tetrodotoxin, nociceptor, nav1.8 and nav1.9
3) Confidence 0.81 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12046980 Disease Relevance 0.26 Pain Relevance 1.03
Nav1.8 and Nav1.9 contain an amino acid sequence common to tetrodotoxin resistant Na+ channels and are localized in peripheral nociceptors.
Localization (localized) of Nav1 in nociceptors associated with tetrodotoxin, nociceptor, nav1.8 and nav1.9
4) Confidence 0.81 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12046980 Disease Relevance 0.26 Pain Relevance 1.03
The somato-dendritic localization of Nav1.1 and Nav1.6 in Purkinje cells suggests that these isoforms are involved in the integration of synaptic input.
Localization (localization) of Nav1 in Purkinje cells associated with nav1.1 and nav1.6
5) Confidence 0.78 Published 2003 Journal Cerebellum Section Abstract Doc Link 12882229 Disease Relevance 0.07 Pain Relevance 1.68
Protein for Nav1.2 and Nav1.6 is localized primarily in granule cell parallel fibers.
Localization (localized) of Nav1 in parallel fibers associated with nav1.2 and nav1.6
6) Confidence 0.78 Published 2003 Journal Cerebellum Section Abstract Doc Link 12882229 Disease Relevance 0.06 Pain Relevance 1.66
Protein for Nav1.2 and Nav1.6 is localized primarily in granule cell parallel fibers.
Localization (localized) of Nav1 in parallel fibers associated with nav1.2 and nav1.6
7) Confidence 0.78 Published 2003 Journal Cerebellum Section Abstract Doc Link 12882229 Disease Relevance 0.06 Pain Relevance 1.66
The somato-dendritic localization of Nav1.1 and Nav1.6 in Purkinje cells suggests that these isoforms are involved in the integration of synaptic input.
Localization (localization) of Nav1 in Purkinje cells associated with nav1.1 and nav1.6
8) Confidence 0.78 Published 2003 Journal Cerebellum Section Abstract Doc Link 12882229 Disease Relevance 0.07 Pain Relevance 1.68
It is therefore conceivable that the SCN9A mutations described here also cause misfolding of the channel which leads to ER retention and hence defective cell surface localization of Nav1.7.
Localization (localization) of Nav1.7 associated with nav1.7
9) Confidence 0.77 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.17 Pain Relevance 0.42
To study the effect of these mutations on the cellular localization of Nav1.7, FLAG-tagged SCN9A constructs were generated.
Localization (localization) of Nav1.7 associated with nav1.7
10) Confidence 0.77 Published 2010 Journal Human Mutation Section Body Doc Link PMC2966863 Disease Relevance 0.13 Pain Relevance 0.69
We find that as in control animals, most mutant nodes of Ranvier had Nav1.6 in high-density clusters in the peripheral and central nervous systems; the localization of Nav1.2 and the protein levels of Nav1.2 and Nav1.6 were also normal in the CGT-deficient mouse.
Localization (localization) of Nav1 in central nervous systems associated with nav1.2 and nav1.6
11) Confidence 0.75 Published 2003 Journal Glia Section Abstract Doc Link 14515333 Disease Relevance 0 Pain Relevance 0.97
Our immunohistochemical observations of the Nav1.1 are clearly distinct to the previous studies, and our findings has corrected the view of the Nav1.1 protein distribution.
Localization (observations) of Nav1 associated with nav1.1
12) Confidence 0.75 Published 2009 Journal Brain Dev. Section Abstract Doc Link 19203854 Disease Relevance 0.91 Pain Relevance 0.50
To investigate the localization of the Nav1.4, we coimmunolabeled it with ?
Spec (investigate) Localization (localization) of Nav1
13) Confidence 0.73 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.05
As expected, Nav1.4 colocalized quite well with ?
Localization (colocalized) of Nav1
14) Confidence 0.73 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.06 Pain Relevance 0.13
Interestingly, Nav1.4 in our experiments with skeletal muscle colocalized with syntrophin, similarly to what has been described for the cardiac isoform Nav1.5 (Gee et al., 1998; Gavillet et al., 2006).
Localization (colocalized) of Nav1 in skeletal muscle
15) Confidence 0.73 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.05 Pain Relevance 0.04
This is supported by the fact that Nav1.7 is transported to nerve terminals of sensory neurons [10] and that Nav1.8 currents are localized in the terminals [23].


Localization (localized) of Nav1 in nerve associated with nav1.8 and nav1.7
16) Confidence 0.71 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.58 Pain Relevance 1.87
These studies confirm the importance of Nav1.7 and Nav1.8 in the physiological processes that underlie altered peripheral thresholds in inflammatory pain.
Localization (importance) of Nav1 associated with eae, nav1.8 and nav1.7
17) Confidence 0.71 Published 2005 Journal Mol Pain Section Body Doc Link PMC1215513 Disease Relevance 1.09 Pain Relevance 1.87
This is because Nav1.3 is deleted in all cell types regardless of the extent to which they up-regulate Nav1.3, the type of cells involved (small vs large sensory neurons and DRG vs central neurons) and the sub-cellular localization of Nav1.3 (somata vs terminals).
Localization (localization) of Nav1 in sensory neurons associated with nav1.3
18) Confidence 0.71 Published 2006 Journal Mol Pain Section Body Doc Link PMC1630424 Disease Relevance 0.68 Pain Relevance 1.71
We show here that adult-onset chronic demyelination, such as occurs in demyelinating disorders and after nerve injury, alters the complement of axonal voltage-dependent Na+ (Nav) channel isoforms and their localization.
Localization (localization) of Nav in nerve associated with demyelination, nervous system injury and demyelinating disease
19) Confidence 0.70 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898531 Disease Relevance 0.78 Pain Relevance 0.49
We conclude that myelin is crucial not only for node of Ranvier formation, but also to actively maintain the proper localization and complement of distinct axonal Nav channel isoforms throughout life.
Localization (localization) of Nav in node
20) Confidence 0.70 Published 2003 Journal J. Neurosci. Res. Section Abstract Doc Link 12898531 Disease Relevance 0.67 Pain Relevance 0.58

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